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The article is VERY long so I will only post some bits of it.
**broken link removed**
Insulin mediates blood lipids. That patient who had a triglyceride of 2200, one of the easiest things we can do is lower triglyceride levels. It is so simple. There was just an article in J.A.M.A. an article and they were saying that the medical profession doesn't know how to reduce triglycerides dietarily, that drugs still need to be used.
It is so ridiculous because you will find that it is the easiest thing to do. They come tumbling down. There is almost a direct correlation between triglyceride levels and insulin levels. In some people more than others. The gentleman who had a triglyceride level of 2200 while on all the drugs only had an insulin level of 14.7.
That is only slightly elevated, but it doesn't take much in some people, all we had to do was get his insulin level down to 8 initially and then it went down to six and that got his triglycerides down to under 200.
How else does insulin affect cardiovascular disease?
We've only just touched upon it. Insulin is a so-called mytogenic hormone. It stimulates cell proliferation. It stimulates cells to divide. If all of the cells were to become resistant to insulin we wouldn't have that much of a problem. The problem is that all of the cells don't become resistant.
Some cells are incapable of becoming very resistant. The liver becomes resistant first, then the muscle tissue, then the fat. When the liver becomes resistant, what is the effect of insulin on the liver, it is to suppress the production of sugar.
The sugar floating around in your body at any one time is the result of two things, the sugar that you have eaten and how much sugar your liver has made. When you wake up in the morning it is more of a reflection of how much sugar your liver has made. If your liver is listening to insulin properly it won't make much sugar in the middle of the night. If your liver is resistant, those brakes are lifted and your liver starts making a bunch of sugar so you wake up with a bunch of sugar.
The next tissue to become resistant is the muscle tissue. What is the action of insulin in muscles? It allows your muscles to burn sugar for one thing. So if your muscles become resistant to insulin it can't burn that sugar that was just manufactured by the liver. So the liver is producing too much, the muscles can't burn it, and this raises your blood sugar.
Well the fat cells become resistant, but not for a while. It is only after a while that they become resistant. It takes them longer.
Liver first, muscle second, and then your fat cells.
So for a while your fat cells retain their sensitivity. What is the action of insulin on your fat cells? To store that fat. It takes sugar and it stores it as fat. So until your fat cells become resistant you get fat, and that is what you see. As people become more and more insulin resistant, they get fat and their weight goes up.
But eventually they plateau. They might plateau at three hundred pounds, two hundred and twenty pounds, one hundred and fifty pounds, but they will eventually plateau as the fat cells protect themselves and become insulin resistant.
As all these major tissues, this massive body becomes resistant, your liver, muscles and fat, your pancreas is putting out more insulin to compensate, so you are hyperinsulinemic and you've got insulin floating around all the time, 90 units, more.
But there are certain tissues that aren't becoming resistant such as your endothelium, the lining of the arteries do not become resistant very readily. So all that insulin is effecting the lining of your arteries.
If you drip insulin into the artery of a dog, there was a Dr. Cruz who did this in the early 70's by accident, he was doing a diabetic experiment and found out that the femoral artery that the insulin was being dripped into was almost totally occluded with plaque after about three months.
The contra lateral side was totally clear, just contact of insulin in the artery caused it to fill up with plaque. That has been known since the 70's, it has been repeated in chickens, in dogs, it is really a well-known fact. Insulin floating around in the blood causes a plaque build up. They didn't know why, but we know that insulin causes endothelial proliferation, that's the first step, it causes a tumor, an endothelial tumor.
This is what causes insulin resistance.
That is definitely what worsens it. Any time your cell is exposed to insulin it is going to become more insulin resistant. That is inevitable, we cannot stop that, but the rate we can control. An inevitable sign of aging is an increase in insulin resistance.
That rate is variable, if you can slow down that rate you can become a centenarian, and a healthy one. You can slow the rate of aging. Not just even the rate of disease, but the actual rate of aging itself can be modulated by insulin. We talked about some of the lower animals and there is some pretty good evidence that even in humans we still retain the capacity to control lifespan at least partially. We should be living to be 130, 140 years old routinely.
Let's talk about carbohydrates, what are they? We talk about simple and complex carbohydrates, that is totally irrelevant, it means absolutely nothing. Carbohydrates are fiber or non-fiber. Few things in life are as clear-cut as this. Fiber is good for you, and a non-fiber carb is bad for you. You can bank on that.
There is not a whole lot of middle ground. If you have a carbohydrate that is not a fiber it is going to be turned into a sugar, whether it be glucose or not. It may be fructose and won't necessarily raise your blood glucose, fructose is worse for you then glucose, so if you just go by blood sugar, which is just glucose, it doesn't mean that you are not raising your blood fructose, or your blood galactose which is the other half of lactose.
All of those sugars are as bad or worse for you than glucose. You can't just go by so-called blood sugar which is just blood glucose, because we just don't measure blood fructose or blood galactose, but they are all bad for you. Why are they bad, well number one we know that it provokes insulin and every time you provoke insulin it exposes yourself to more insulin and just like walking in a smelly room it is going to become more resistant to insulin.
So every time you have a surge of sugar and you have a surge of insulin, you get more and more insulin resistant and all of the problems we've talked about
**broken link removed**
Insulin mediates blood lipids. That patient who had a triglyceride of 2200, one of the easiest things we can do is lower triglyceride levels. It is so simple. There was just an article in J.A.M.A. an article and they were saying that the medical profession doesn't know how to reduce triglycerides dietarily, that drugs still need to be used.
It is so ridiculous because you will find that it is the easiest thing to do. They come tumbling down. There is almost a direct correlation between triglyceride levels and insulin levels. In some people more than others. The gentleman who had a triglyceride level of 2200 while on all the drugs only had an insulin level of 14.7.
That is only slightly elevated, but it doesn't take much in some people, all we had to do was get his insulin level down to 8 initially and then it went down to six and that got his triglycerides down to under 200.
How else does insulin affect cardiovascular disease?
We've only just touched upon it. Insulin is a so-called mytogenic hormone. It stimulates cell proliferation. It stimulates cells to divide. If all of the cells were to become resistant to insulin we wouldn't have that much of a problem. The problem is that all of the cells don't become resistant.
Some cells are incapable of becoming very resistant. The liver becomes resistant first, then the muscle tissue, then the fat. When the liver becomes resistant, what is the effect of insulin on the liver, it is to suppress the production of sugar.
The sugar floating around in your body at any one time is the result of two things, the sugar that you have eaten and how much sugar your liver has made. When you wake up in the morning it is more of a reflection of how much sugar your liver has made. If your liver is listening to insulin properly it won't make much sugar in the middle of the night. If your liver is resistant, those brakes are lifted and your liver starts making a bunch of sugar so you wake up with a bunch of sugar.
The next tissue to become resistant is the muscle tissue. What is the action of insulin in muscles? It allows your muscles to burn sugar for one thing. So if your muscles become resistant to insulin it can't burn that sugar that was just manufactured by the liver. So the liver is producing too much, the muscles can't burn it, and this raises your blood sugar.
Well the fat cells become resistant, but not for a while. It is only after a while that they become resistant. It takes them longer.
Liver first, muscle second, and then your fat cells.
So for a while your fat cells retain their sensitivity. What is the action of insulin on your fat cells? To store that fat. It takes sugar and it stores it as fat. So until your fat cells become resistant you get fat, and that is what you see. As people become more and more insulin resistant, they get fat and their weight goes up.
But eventually they plateau. They might plateau at three hundred pounds, two hundred and twenty pounds, one hundred and fifty pounds, but they will eventually plateau as the fat cells protect themselves and become insulin resistant.
As all these major tissues, this massive body becomes resistant, your liver, muscles and fat, your pancreas is putting out more insulin to compensate, so you are hyperinsulinemic and you've got insulin floating around all the time, 90 units, more.
But there are certain tissues that aren't becoming resistant such as your endothelium, the lining of the arteries do not become resistant very readily. So all that insulin is effecting the lining of your arteries.
If you drip insulin into the artery of a dog, there was a Dr. Cruz who did this in the early 70's by accident, he was doing a diabetic experiment and found out that the femoral artery that the insulin was being dripped into was almost totally occluded with plaque after about three months.
The contra lateral side was totally clear, just contact of insulin in the artery caused it to fill up with plaque. That has been known since the 70's, it has been repeated in chickens, in dogs, it is really a well-known fact. Insulin floating around in the blood causes a plaque build up. They didn't know why, but we know that insulin causes endothelial proliferation, that's the first step, it causes a tumor, an endothelial tumor.
This is what causes insulin resistance.
That is definitely what worsens it. Any time your cell is exposed to insulin it is going to become more insulin resistant. That is inevitable, we cannot stop that, but the rate we can control. An inevitable sign of aging is an increase in insulin resistance.
That rate is variable, if you can slow down that rate you can become a centenarian, and a healthy one. You can slow the rate of aging. Not just even the rate of disease, but the actual rate of aging itself can be modulated by insulin. We talked about some of the lower animals and there is some pretty good evidence that even in humans we still retain the capacity to control lifespan at least partially. We should be living to be 130, 140 years old routinely.
Let's talk about carbohydrates, what are they? We talk about simple and complex carbohydrates, that is totally irrelevant, it means absolutely nothing. Carbohydrates are fiber or non-fiber. Few things in life are as clear-cut as this. Fiber is good for you, and a non-fiber carb is bad for you. You can bank on that.
There is not a whole lot of middle ground. If you have a carbohydrate that is not a fiber it is going to be turned into a sugar, whether it be glucose or not. It may be fructose and won't necessarily raise your blood glucose, fructose is worse for you then glucose, so if you just go by blood sugar, which is just glucose, it doesn't mean that you are not raising your blood fructose, or your blood galactose which is the other half of lactose.
All of those sugars are as bad or worse for you than glucose. You can't just go by so-called blood sugar which is just blood glucose, because we just don't measure blood fructose or blood galactose, but they are all bad for you. Why are they bad, well number one we know that it provokes insulin and every time you provoke insulin it exposes yourself to more insulin and just like walking in a smelly room it is going to become more resistant to insulin.
So every time you have a surge of sugar and you have a surge of insulin, you get more and more insulin resistant and all of the problems we've talked about
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