My sister is an RN at a hospital in a large city. She rolls her eyes whenever someone brings up the "YOLO" way of life. As in party hard, do what you want and if you die of a heart attack at 40 so be it.
She says that realistically you won't die, but you will have serious complications, like a stroke. Then instead of living fast and dangerous you have twenty years of someone spoonfeeding you lime jello and changing your Depends.