Metformin to prevent gh insulin desensitization?

[Tyler Durden]

Since gh decreases insulin sensitivity and metformin (glucophage) is designed to increase it, would using both in conjunction be a good idea?

 

[FasTwitch]

Metformin seems to be counterproductive and less than complementary to many of GH/IGF's interactions (bottom half of this post by Dat explains the science)...


http://www.professionalmuscle.com/forums/showpost.php?p=480576&postcount=305

 

[Tyler Durden]

Thanks for pointing that out. Love that thread but there's way too much information in it to try to find one specific detail.

 

[EasyEJL]

the interactions are all so horribly complicated, its sometimes a wonder we can grow at all

 

[DatBtrue]

the interactions are all so horribly complicated, its sometimes a wonder we can grow at all

Amen.

Tyler the best approach is to look at what the best trainers do.

Razor Ripped is aware of that post and now tempers the use of Metformin BUT as both he and I agree Metformin has a huge benefit in several ways.

When he asked me if I thought it should be abandoned I told him "hell no". Just pay more attention to when and how you use it.

He had great success with his trainees who use Met and he still has great success with his trainees who use Met.

And... like everything else more attention needs to be paid to such details IF you are natural. Steroids allow people to not be forced to focus on that much detail...

 

[T TOTAL]

Amen.

Tyler the best approach is to look at what the best trainers do.

Razor Ripped is aware of that post and now tempers the use of Metformin BUT as both he and I agree Metformin has a huge benefit in several ways.

When he asked me if I thought it should be abandoned I told him "hell no". Just pay more attention to when and how you use it.
He had great success with his trainees who use Met and he still has great success with his trainees who use Met.And... like everything else more attention needs to be paid to such details IF you are natural. Steroids allow people to not be forced to focus on that much detail...

Dat, great scientific thread in the post above.....But are you able to elaborate, perhaps in laymans terms on some points youve made above...Would be very much appreciated...

 

[MrCyp]

I think what it comes down to is you dont need IGF levels increased 24/7 so use metaformin when your not using something to increase IGF levels. For example pwo say you shoot some ghrp6 and then 2iu's of GH 20min later. Wait a few hours for the GH to clear and then take your metaformin with a high carb meal

 

[PsyT]

can we just use MET alone without using any GH or insulin? Would this help improve insulin sensitivity?

 

[MrCyp]

can we just use MET alone without using any GH or insulin? Would this help improve insulin sensitivity?

Yes but it will still lower IGF levels for about 4hrs