Type 2 diabetic here. Have tried MK-677 for two days and my serum glucose shot up from 145 after a meal to 224 and that's with taking 44 IU of basal insulin once daily. If you're Type 2 diabetic and you take MK-677 you may see a big jump in your serum glucose. I had to take 20 IU of R insulin on top of my usual 44 IU of basal insulin which brought me back down to 130 a couple hours later. I have stopped taking MK-677 due to it's effect on my insulin sensitivity.