New IGF theories, Grunt?? Zombato?? Any thoughts???

[Juice Freak]

So it seems there are two theories about the best time to use Igfr3. The theory that post workout is the best time since the muscles are damaged and will be receptive to the larger amount of igf floating around so this would minimize spill over and the growing of other organs especially intestines. Then the theory that igf post workout will cause interference of myotube formation due to the naturally increased level of mgf caused by the muscles being damaged during workout. I am thinking about giving an alternative method a try. Please post you thoughts igf pros and theorists.

My questions are:

How lond does natural mgf levels stay elevated post workout?

How long will the damaged muscles be optimally receptive to igf introduction post workout???

If I use igf in muscles trained the day before will they still be receptive and will I have a greater level of systemic spill over???

What is the half life of igfr3 since there are a lot of different opinions on this I'm curious as to what the most common consensus is.

Please let me know what your thoughts are and maybe we can make this a sticky.

 

[Research Em]

this confidential document from Novozymes GroPep Limited
titled

LONG R3IGF-I
Safety Review
Addressing the use of LONG®R3IGF-
biopharmaceutical manufacture

provide some answers, I hope it may help

---
R Em

 

[C--Man]

could not open Bro..

 

[Research Em]

could not open Bro..

try right click and "save as" , attachment opens fine, bro

You should have Arcobat Reader installed on your computer

here is some most important exerts from this document

The effects of IGF-I are modified by a family of six specific IGF-binding proteins (IGFBPs). The IGFBPs generally inhibit the action of IGF-I, but because of the complex nature of the regulatory system they can have stimulatory effects. The IGFBPs are, in turn regulated by specific
proteases. It is important to understand that under normal physiological conditions IGF-I is present in the circulation and in all tissues at a relatively high concentration. For example, the normal concentration range of IGF-I in the blood of an adult human is 100 to 300 μg/L.

The experimental data shows that LONG®R3IGF-I clearance rate in animals is about 10-fold higher than that of IGF-I as a result of low binding to circulating IGF binding proteins. Despite the higher clearance rate LONG®R3IGF-I is more potent than IGF-I in a number of physiological and metabolic responses in animal models.

During the last 15 years, IGF-I has been administered to humans in a number of clinical trials to evaluate its potential benefit in conditions of GH deficiency, diabetes, muscle wasting diseases, multiple sclerosis, kidney disease and gastro-intestinal surgery. The length of treatment varied from days to years and the doses ranged from 5μg/kg/day to 1500μg/kg/day.

Analysis of pharmacokinetic data in normal subjects is also important. A dose of 40mcg/kg/day resulted in an increase of 150μg/L above the starting baseline IGF-I concentration. The half-life in the circulation was approximately 20h and suggested an endogenous production rate of IGF-I by the body of 3 mg per day.

Rapid clearance of LONG®R3IGF-I from the circulation, with a half life of less than 10 minutes in animal studies including primates and deduced from clearance of “free” IGF-I in humans.

 

[C--Man]

OK got it, thanks....

Classified,

A lot of the componds we use to personally enhance our bodys

like GH, MGF and IGF will be widely used to heal and even save lives in the future..

There are 2 doctors in USA injecting GH into joints for severe Arthrititis with good success...

MGF has a big future in medicine as well.......