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Newer Hairloss treatmnets being used

dragonfire101

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New treatments being used for hairloss.



Platelet Rich Plasma therapy (PRP)

Platelet Rich Plasma or PRP is a revolutionary new treatment for hair loss. It is versatile and can be used with hair transplant surgery, or as an independent treatment for thinning hair. Many hair transplant surgeons are already using this technology in their hair replacement surgery, and since the expert presentations to over 400 surgeons at the ISHRS conference in July, many more will soon start using the procedure.

PRP therapy is performed in 3 stages. First, an amount of blood between 60-100ml is taken from the patient and centrifuged. The fraction that contains the most platelets and growth factors is then removed and kept. The platelet rich fraction may be divided and one part lysed to release more growth factors then combined with the other whole-platelet factor. This extra treatment is claimed to increase the effects of PRP therapy, especially for hair loss.

Secondly the scalp is stimulated to activate the wound healing process. This process needs to be activated in order to use the growth factors and platelets that PRP therapy gives. Previously PRP activation needed to be completed with a single needle. 100's of punctures are necessary for the activation step, and so using a single needle was impractical and caused the patient significant amounts of pain. Now, a new product called the Scalproller manufactured by Nanogen is widely used for the activation step. The Scalproller is a microneedle roller that uses 192 unique titanium needles to open the skin to the same depth every time, and as it uses less pressure it causes less pain. As the Scalproller is rolled over the scalp, it saves the surgeon time as well.

The third step in the PRP process is the re-injection of the platelet and growth factor rich fragment into the scalp. This provides high levels of every factor needed for healing and healthy hair growth, the factors are utilised by the stimulated cells, including hair follicles.

The stimulation and access to high concentrations of growth factors has been shown to generate new hair growth, thicken existing hair growth, and make hair transplants grow thicker and healthier. In one case an Alopecia Areata patient was treated, and PRP treatment caused hair regrowth.

These findings were presented at the ISHRS conference along with the launch of Nanogen's Scalproller, and PRP with Scalproller pre-treatment is looking to become widespread as a hair loss treatment.

Written by Toby Cobbledick for Nanogen Hair Loss Research

Extracellular Matrix (“ECM”) ACell Inc.,


Hair Loss Solutions And News / Extracellular Matrix Used on Injured Soldiers : What This Could Mean for Hair Loss Sufferers
Extracellular Matrix Used on Injured Soldiers : What This Could Mean for Hair Loss Sufferers

Posted by Emilie on Tuesday, May 4, 2010

The Daily Mail, a popular British periodical, recently did a feature on the use of extracellular matrix (ECM) products on soldiers injured in Afghanistan. ECM is derived from the porcine membrane of bladder and can be used as a regenerative medicine. The Daily Mail article claims that it has even been used to save soldiers who were so badly injured at war that they risked amputation. In one example, the ECM product was used to repair a massive leg wound; it was able to grow nerves, muscles and ordinary tissue where there had been none. ACell, Inc., a company based in Columbia, Maryland, has developed and refined what they consider, “the next generation of regenerative medicine.”

ACell is just one variety of ECM recently FDA-approved for use in humans. When applied to injured tissue, ACell can stimulate the regeneration of normal tissue. Several pioneering hair transplant surgeons took an early interest in ACell and have been studying possible uses for the product as it relates to hair restoration. Doctors Jerry Cooley and Gary Hitzig released some of the first reports about their findings on whether ACell might be beneficial for strip surgery patients. Unfortunately, at this time, their reports are inconclusive.

Dr. Cole has been following news of ACell since 2007. Now that it is indicated for safe use in humans, he is researching ACell as it relates to his Cole Isolation Technique (CIT) patients. He is currently exploring whether the use of ACell may reduce the appearance of hypopigmentation, the tiny white spotting that some FUE and CIT patients develop when grafts are removed from the donor region. Dr. Cole is hopeful that ACell may help to improve melanocyte stimulation, and to improve the overall appearance of the donor area.

A secondary interest Dr. Cole has in ACell is whether it will stimulate cells left behind when grafts are extracted, and possibly induce the development of new hair growth. The hope is that, through the delivery of ACell to our extraction sites, he will be able to attract and induce hair follicle stem cells to reproduce a re-growth of the extracted follicles. At this time, Dr. Cole has not yet seen any evidence that ACell promotes any new hair growth. The objective going forward is to unlock the specific methods necessary to regenerate hair. Given that ACell has already successfully regenerated muscle, skin, nerves, specific organ tissue, etc., it is reasonable to suspect that it should be able to regenerate hair. The challenge lies in engineering a specific means of delivering the product to the appropriate stem cells.

To read the complete Daily Mail article, click here:


"Magic ‘Pixie Dust’ made from pig bladders helps ‘regrow’ limbs of wounded soldiers"

http://www.dailymail.co.uk/sciencet...-bladders-regrows-limbs-wounded-soldiers.html


"MatriStem MicroMatrix – Regenerative Medicine and Hair Cloning"

http://blog.americanhairloss.org/hair-loss/matristem-micromatrix-regenerative-medicine-hair-cloning/


Another company using ECM Histogen "HSC Trial Shows Continued Significant Hair Growth at One Year Follow-up" halfway down page of the Link

http://www.histogen.com/aboutus/news_events.htm
 
Last edited:

TheOtherOne55

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VERY interesting. Im in my 20's and i'm getting hit haard by MPB while on cycle. Looks very promising, hopefully this is the new technology everyone is running to in the next 3-5 years.
 

max5000

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When Donald Trumps hair looks normal.... then I'll believe someone has come up with a legitimate solution....
 

TheTank

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When Donald Trumps hair looks normal.... then I'll believe someone has come up with a legitimate solution....

Me too, we need a peptide that regrows hair, that would probably become more popular than Viagra. Going bald sucks.
 

dragonfire101

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Me too, we need a peptide that regrows hair, that would probably become more popular than Viagra. Going bald sucks.

Astressin B and DS Laboratories came out with a topical version (Spectral 7) few months back. Just not sure how well it works topically as in the studies mice grew lots of hair when they were injected with it.


DS Laboratories
 

Rep

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I have read your info on minoxidil and ketoconazole. I can get both in a cream form. Has it worked for you and can I mix the creams 50/50 and apply at night.
I hate losing my hair
 

Hunk Chunk

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I had the PRP method done in Russia just a few weeks ago, using the painful 100's of pins in head method. It didn't really hurt that much at all - at least for those of us used to pinning a lot. I will report back in this forum about its results in a thread I started in this section. So far at week 3 it feels thicker and stronger, ie. better attached to the scalp, but no signs yet of it growing back. More soon.

Hunk Chunk
 

zaven

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Must have not been the breakthrough like they thought otherwise it would be all over the tv, net, etc by now.
 

ParisFR83

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Interesting. I am the point on accepting the fact I will never have thick full hair again and to start shaving my head
 

dragonfire101

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Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia


Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia
Luis A. Garza,1,* Yaping Liu,2 Zaixin Yang,1 Brinda Alagesan,1 John A. Lawson,3 Scott M. Norberg,1 Dorothy E. Loy,4 Tailun Zhao,1 Hanz B. Blatt,1 David C. Stanton,5 Lee Carrasco,5 Gurpreet Ahluwalia,6,† Susan M. Fischer,7 Garret A. FitzGerald,3 and George Cotsarelis1,‡
Author information ► Copyright and License information ►
The publisher's final edited version of this article is available at Sci Transl Med
See other articles in PMC that cite the published article.
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Abstract

Testosterone is necessary for the development of male pattern baldness, known as androgenetic alopecia (AGA); yet, the mechanisms for decreased hair growth in this disorder are unclear. We show that prostaglandin D2 synthase (PTGDS) is elevated at the mRNA and protein levels in bald scalp compared to haired scalp of men with AGA. The product of PTGDS enzyme activity, prostaglandin D2 (PGD2), is similarly elevated in bald scalp. During normal follicle cycling in mice, Ptgds and PGD2 levels increase immediately preceding the regression phase, suggesting an inhibitory effect on hair growth. We show that PGD2 inhibits hair growth in explanted human hair follicles and when applied topically to mice. Hair growth inhibition requires the PGD2 receptor G protein (heterotrimeric guanine nucleotide)–coupled receptor 44 (GPR44), but not the PGD2 receptor 1 (PTGDR). Furthermore, we find that a transgenic mouse, K14-Ptgs2, which targets prostaglandin-endoperoxide synthase 2 expression to the skin, demonstrates elevated levels of PGD2 in the skin and develops alopecia, follicular miniaturization, and sebaceous gland hyperplasia, which are all hallmarks of human AGA. These results define PGD2 as an inhibitor of hair growth in AGA and suggest the PGD2-GPR44 pathway as a potential target for treatment.
 

dragonfire101

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Kythera Biophrarma (KYTH) Enters Hair Loss IP Agreement with Actelion Pharma, Univ. o

Kythera Biophrarma (NASDAQ: KYTH) has entered into separate license agreements with Actelion Pharmaceuticals Ltd. and the University of Pennsylvania for a novel approach for the treatment of hair loss, which together could enable KYTHERA to bring a new treatment to the very large and still highly unsatisfied hair loss market.

"These two licenses build on KYTHERA's focus on developing and commercializing high-value, self-pay aesthetic products that have the promise to yield high patient satisfaction and enhanced self image," said Keith Leonard, KYTHERA's president and CEO. "Based on several years of research and clinical work already accomplished, we believe we have the possibility of reaching initial proof-of-concept data in a very capital efficient manner."

Under the terms of the agreement with Actelion, KYTHERA Holdings Ltd., a wholly-owned Bermuda subsidiary of KYTHERA Biopharmaceuticals, Inc., licensed the worldwide rights to setipiprant, a clinical-stage selective and potent oral antagonist to the prostaglandin D2 (PGD2) receptor. As part of the agreement, Actelion will be eligible to receive up to $27 million in potential development and regulatory milestones, as well as royalties on sales if setipiprant is successfully commercialized.

Under the terms of the agreement with the University of Pennsylvania, KYTHERA Holdings Ltd., acquired exclusive worldwide rights to certain patent rights owned by the University of Pennsylvania covering the use of PGD2 receptor antagonists for the treatment of hair loss (often presenting as male pattern baldness, or androgenic alopecia) under a license agreement facilitated by the Penn Center for Innovation. The discovery of the relationship between PGD2 and hair loss was made in the laboratory of Dr. George Cotsarelis and published in late 20111. KYTHERA has been supporting research in Dr. Cotsarelis' lab at the University of Pennsylvania over the last two years under sponsored research and option agreements to further develop and elucidate the initial reported observations.

Kythera Biophrarma (KYTH) Enters Hair Loss IP Agreement with Actelion Pharma, Univ. of Pennsylvania

"The University of Pennsylvania's discovery and associated intellectual property assets, combined with access to the PGD2 antagonist setipiprant, provide KYTHERA a strong foundation for this novel approach to hair loss," said Frederick Beddingfield, III, M.D., Ph.D., KYTHERA's Chief Medical Officer. "These observations are potentially the most innovative new thinking in hair loss over the last two decades. Setipiprant is believed to directly affect this hair loss pathway, and our own preclinical and in vitro human hair models confirmed this effect. It is a well-characterized molecule with a large safety database and we believe we can quickly initiate a development program to study it in hair loss. Putting these two pieces of the puzzle together is ideal and represents an example of our approach to scientifically sound and efficient drug development."

KYTHERA plans to conduct a human proof-of-concept study to establish the efficacy of setipiprant in male subjects with androgenic alopecia (AGA).
 

dragonfire101

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PGD2 Inhibitors

— The biggest news so far this month is Allergan’s purchase of Kythera Biopharmaceuticals yesterday. While Allergan is largely known for its blockbuster Botox product, for us hair loss sufferers, the company’s Bimatoprost product is is all we care about. While Kythera’s most well known product is its recently approved ATX-101 (brand name Kybella) china fat reducing topical product, for us hair loss sufferers, the company’s Setipiprant product is all we care about. Bimatoprost is essentially (but not exactly) a prostaglandin E2 (PGE2) analog and Setipiprant is a prostaglandin D2 (PGD2) antagonist. The latter holds far greater potential to be a cure for hair loss compared to the former. A combination treatment with the two drugs (i.e, increase PGE2 and decrease PGD2) has in the past been postulated to be the perfect treatment to regrow hair. I would urge all blog readers to listen to this encouraging audio segment on Setipiprant from an investor call earlier this year.

— An interesting article on a doctor in Texas using PRP with stem cells derived from a donor’s placenta to treat hair loss.

— The renowned Dr. John Cole is planning to do a major study on the effectiveness of platelet-rich plasma (PRP) therapy, and is looking for volunteers. The PRP treatment will entail three sessions (once a month for three months) costing a total of $750, an absolute steal. Moreover, it seems like Dr. Cole will refund that $750 too if you show up for a follow-up 6-12 months after the first injection session. Dr. Cole will test many different treatment protocols, including using a variety of extracellular matrix (ECM) products and activation methods. PRP is still fairly new when it comes to the hair loss world, with many significant differences in methodology and ingredients existing between different doctors and hair transplant surgeons. Such a study needed to be done a few years ago. Better late then never of course. If you do volunteer for this study, please make sure you know exactly what Dr. Cole will inject into your scalp. He is very well respected and unlikely to do anything even remotely risky, but when you are injecting something into your scalp (or really anywhere into your body), it is best to be very cautious.

And now on to medical items of interest:

A new study finds that keeping PGE2 levels high in mice by reducing 15-PGDH promotes tissue regeneration. It seemes like PGE2 has many benefits besides hair growth.



Sooo....use of PGE2, Cloprostenol APGF2a Agonist or Ramatroban a PGD2 receptor antagonist, also a GPR-44 receptor antagonist, which actually Ramatroban indicted in use for asthma and coronary artery disease.


Where are the peptide sponsor on this stuff?
 

elite11

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I've tried it all. Rogain Propecia Biotin etc. Pills and shampoos. Nothing works. The hair transplant is expensive and I hear leaves a nasty scar. Anyone have any experience w this? Im beginning to become convinced that once it's gone it's gone.
 

Anubis

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I've tried it all. Rogain Propecia Biotin etc. Pills and shampoos. Nothing works. The hair transplant is expensive and I hear leaves a nasty scar. Anyone have any experience w this? Im beginning to become convinced that once it's gone it's gone.

the old transplants leave a nasty scar but from the pictures ive seen the fue technique looks to be scar free after the first few weeks of healing and the pricing if done abroad looks very reasonable for a cosmetic procedure.
 

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