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nolva DOES in fact reduce prolactin

bignripped

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Jun 23, 2006
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Tamoxifen inhibits prolactin signal transduction in ER - NOG-8 mammary epithelial cells.
Das R, Vonderhaar BK.
Laboratory of Tumor Immunology and Biology, National Cancer Institute

Tamoxifen (TAM), an antiestrogen, also acts as an antilactogen in mammary cells. In the present study we analyze the effect of TAM on the signal transduction pathway for prolactin (Prl). TAM bound specifically to NOG-8, an estrogen receptor-negative mammary cell line. Within 5 min of Prl treatment, raf-1, MEK and MAP kinase were induced 2-3-fold over the control level. TAM completely inhibited this Prl-induced activation of kinases as well as Prl binding and cell growth. These results indicate the potential role of TAM as an antilactogen in Prl responsive systems.
 

EDED

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Jan 31, 2009
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makes sense,,,blocking E at the titties will do that of course.

i think folks were using some studies that showed upregulation of progesterone receptors, which has no direct relationship to prolactin as far as i know..i could be wrong,,,i said no DIRECT effect however.
 

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