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Cjc 1295 + ghrp6 - boards.ie
The second study is the one that established the saturation dose for these peptides often used in other studies. "Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone ", CY Bowers..., J. Clin. Endocrinol. Metab., Apr 1990; 70: 975-982.
http://jcem.endojournals.org/cgi/content/abstract/70/4/975
The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1–44)-NH2
In that study GHRH at a dose of 1.0 microgram/kg was administered alone and then together with various doses of GHRP-6 (0.1, 0.3, and 1.0 microgram/kg). They found that the submaximal dosages of 0.1 and 0.3 microgram/kg GHRP-6 plus 1 microgram/kg GHRH did have the effect of stimulating GH release synergistically.
However the larger dose of 1 mcg/kg of GHRP-6 was found to be the saturation dose when used in combination w/ 1 mcg/kg of GHRH.
It is also noteworthy that serum prolactin and cortisol levels rose about 2-fold above base levels only at the 1 microgram/kg dose of GHRP-6 and not at the submaximal dosages.
The final study, "Preserved Growth Hormone (GH) Secretion in Aged and Very Old Subjects after Testing with the Combined Stimulus GH-Releasing Hormone plus GH-Releasing Hexapeptide-6", Micic D..., J Clin Endocrinol Metab. 1998 Jul;83(7):2569-72 is fascinating for several reasons.
By reference to citation it is noted that "GHRH plus GHRP-6 (both at saturating dose) is nowadays considered the most potent stimulus of GH secretion in man being able to restore the GH secretion in states associated with chronic blockade of somatotroph activity (as in obesity)...it elicits a near-normal GH discharge in obesity, in patients with hypothyroidism and in patients with type 2 diabetes mellitus."
This particular study examined the effects of combined administration of GHRH, immediately followed by GHRP-6 in a group of very old subjects (age higher than 75 yr), as compared with both normal adults (less than 40 yr) and aged subjects (age 46–65 yr). The dosing levels used were 90mcg of GHRH followed by 1mcg/kg of GHRP-6
So - is it possible that the doses recommended on this board were too high and the submaixmal doses are better?
Also - here's a VERY interesting article
Neuroendocrine Control of Growth Hormone Secretion
http://physrev.physiology.org/cgi/content/full/79/2/511
The GH-releasing activity of GHRP-6 was demonstrated in a range of species, i.e., monkeys, sheep, pigs, chicks, steer, and rats (134, 276, 322, 575, 655), as well as in humans (135, 504). Growth hormone-releasing peptide-6 was orally active in rats, dogs, monkeys, and humans (132, 1079), and interestingly, it was 5.3-30 times more effective in monkeys than in rats or dogs. In humans, 1 µg/kg GHRP-6 administered as a bolus injection released more GH than GHRH-44 given at the same dosage and by the same route (131, 135). In healthy humans, comparable amounts of GH were released after intravenous 1 µg/kg GHRP-6 or 300 µg/kg oral GHRP-6 (132).
The second study is the one that established the saturation dose for these peptides often used in other studies. "Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone ", CY Bowers..., J. Clin. Endocrinol. Metab., Apr 1990; 70: 975-982.
http://jcem.endojournals.org/cgi/content/abstract/70/4/975
The acute GH release stimulated by the synthetic hexapeptide, His-DTrp-Ala-Trp-DPhe-Lys-NH2 [GH releasing peptide (GHRP)], was determined in 18 normal men and compared with the effects of GH-releasing hormone, GHRH-(1–44)-NH2
In that study GHRH at a dose of 1.0 microgram/kg was administered alone and then together with various doses of GHRP-6 (0.1, 0.3, and 1.0 microgram/kg). They found that the submaximal dosages of 0.1 and 0.3 microgram/kg GHRP-6 plus 1 microgram/kg GHRH did have the effect of stimulating GH release synergistically.
However the larger dose of 1 mcg/kg of GHRP-6 was found to be the saturation dose when used in combination w/ 1 mcg/kg of GHRH.
It is also noteworthy that serum prolactin and cortisol levels rose about 2-fold above base levels only at the 1 microgram/kg dose of GHRP-6 and not at the submaximal dosages.
The final study, "Preserved Growth Hormone (GH) Secretion in Aged and Very Old Subjects after Testing with the Combined Stimulus GH-Releasing Hormone plus GH-Releasing Hexapeptide-6", Micic D..., J Clin Endocrinol Metab. 1998 Jul;83(7):2569-72 is fascinating for several reasons.
By reference to citation it is noted that "GHRH plus GHRP-6 (both at saturating dose) is nowadays considered the most potent stimulus of GH secretion in man being able to restore the GH secretion in states associated with chronic blockade of somatotroph activity (as in obesity)...it elicits a near-normal GH discharge in obesity, in patients with hypothyroidism and in patients with type 2 diabetes mellitus."
This particular study examined the effects of combined administration of GHRH, immediately followed by GHRP-6 in a group of very old subjects (age higher than 75 yr), as compared with both normal adults (less than 40 yr) and aged subjects (age 46–65 yr). The dosing levels used were 90mcg of GHRH followed by 1mcg/kg of GHRP-6
So - is it possible that the doses recommended on this board were too high and the submaixmal doses are better?
Also - here's a VERY interesting article
Neuroendocrine Control of Growth Hormone Secretion
http://physrev.physiology.org/cgi/content/full/79/2/511
The GH-releasing activity of GHRP-6 was demonstrated in a range of species, i.e., monkeys, sheep, pigs, chicks, steer, and rats (134, 276, 322, 575, 655), as well as in humans (135, 504). Growth hormone-releasing peptide-6 was orally active in rats, dogs, monkeys, and humans (132, 1079), and interestingly, it was 5.3-30 times more effective in monkeys than in rats or dogs. In humans, 1 µg/kg GHRP-6 administered as a bolus injection released more GH than GHRH-44 given at the same dosage and by the same route (131, 135). In healthy humans, comparable amounts of GH were released after intravenous 1 µg/kg GHRP-6 or 300 µg/kg oral GHRP-6 (132).
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