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PDE5 and nitrates

IronLion2

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I'm a little confused on this, I see the combo can drop blood pressure quickly but are we saying bodybuilders never use this with a pre or intra workout product? Almost all of them have some type of nitrate in there, I also read even BCAA/EAA could do it?
 

heavyhitter

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Im not really sure what youre asking. Are you asking if its a bad idea to use both because it could cause an unsafe drop in BP?
 

IronLion2

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Im not really sure what youre asking. Are you asking if its a bad idea to use both because it could cause an unsafe drop in BP?

1) Yes, how bad of an idea is it to mix? My understanding is you dont want to us Cialis/Viagra with things like glycerin, but what about other nitrates like NO precursors?
2) What qualifies as a nitrate as I see people saying aminos would count
 

little slice

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ive used Cialis with lisinopril and potassium nitrate



didn't have any blood pressure problems...




doctors just say to be cognizant of the risk because they don't want to get sued by ambulance chasers... even if the risk is minimal
 

heavyhitter

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1) Yes, how bad of an idea is it to mix? My understanding is you dont want to us Cialis/Viagra with things like glycerin, but what about other nitrates like NO precursors?
2) What qualifies as a nitrate as I see people saying aminos would count

Things like glycerin....or things like nitroglycerin? Nitro is a prescription drug and I probably wouldn't mix them. But naturally occurring nitrates like beet root and stuff youd find in a pre workout shouldn't be any problem
 

mike036

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I have been using beet root powder and low dose daily tadalafil for a couple of months now to keep my blood pressure under control ,the combo is very effective
 

suppdude

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I'd only be concerned and not run the combo if low blood pressure was already an issue.
 

IronLion2

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ive used Cialis with lisinopril and potassium nitrate



didn't have any blood pressure problems...




doctors just say to be cognizant of the risk because they don't want to get sued by ambulance chasers... even if the risk is minimal

thats what I was thinking
 

Mike Arnold

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I'm a little confused on this, I see the combo can drop blood pressure quickly but are we saying bodybuilders never use this with a pre or intra workout product? Almost all of them have some type of nitrate in there, I also read even BCAA/EAA could do it?

You would probably be fine when mixing PDE5 inhibitors and OTC nitrates, but you also need to consider dose. For example, there is a big difference between 10 mg tadalafil + 500 mg sodium nitrate...and 100 mg sildenafil + 2,000 mg sodium nitrate. The later could potentially cause issues (potentially dangerous drop in BP, particularly if your BP is already in an ideal range).


On the other hand, I would NOT mix PDE5 inhibitors with script drugs like nitroglycerin. Nitro by itself can cause dangerous drop in BP, especially at higher dosages. Adding a PDE5 inhibitor to that could potentially spell very bad news.

In conclusion, I would not worry too much about combining OTC nitrates with PDE5 inhibitors. If the OTC product you are considering using has a very high dose of nitrates, such as MA-Pump (1,500 mg sodium nitrate), then you might want to consider using a half-dose when combining it with a PDE5 inhibitor...especially the first time you use it. From there you can make adjustments based on your personal response and needs.

Don't confuse nitroglycerin with glycerin/glycerol, which are two completely different things. Many pump products contain glycerol (HydroMax, GlycerPump, etc), while nitroglycerin is a very potent prescription nitrate that could kill you in the event of an OD.
 

nothuman

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I'm a little confused on this, I see the combo can drop blood pressure quickly but are we saying bodybuilders never use this with a pre or intra workout product? Almost all of them have some type of nitrate in there, I also read even BCAA/EAA could do it?

Been combining them for years. It's fine for most people. Just need to monitor it.
 

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