trenbolone: what you need to know

[SVFootball]

ok so after the controversy brought up during 2BigFred's battle with his health, a lot of people on a couple boards im on have voiced their concerns about the virulent nature of trenbolone and how it is the most dangerous steroid available today. many ideas have been brought up pointing fingers at tren for causing tumors, liver adenomas, and other very serious health problems. ive decided that someone has to get the word out there and try to show how dangerous tren really is, so why not me.

first off, trenbolone is immunotoxic, as can be seen in the following abstract taken off PubMed:

Immunotoxicity of trenbolone acetate in Japanese quail.Quinn MJ Jr, McKernan M, Lavoie ET, Ottinger MA.
U.S. Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, Maryland 21010, USA. [email protected]

Trenbolone acetate is a synthetic androgen that is currently used as a growth promoter in many meat-exporting countries. Despite industry laboratories classifying trenbolone as nonteratogenic, data showed that embryonic exposure to this androgenic chemical altered development of the immune system in Japanese quail. Trenbolone is lipophilic, persistent, and released into the environment in manure used as soil fertilizer. This is the first study to date to assess this chemical's immunotoxic effects in an avian species. A one-time injection of trenbolone into yolks was administered to mimic maternal deposition, and subsequent effects on the development and function of the immune system were determined in chicks and adults. Development of the bursa of Fabricius, an organ responsible for development of the humoral arm of the immune system, was disrupted, as indicated by lower masse, and smaller and fewer follicles at day 1 of hatch. Morphological differences in the bursas persisted in adults, although no differences in either two measures of immune function were observed. Total numbers of circulating leukocytes were reduced and heterophil-lymphocyte ratios were elevated in chicks but not adults. This study shows that trenbolone acetate is teratogenic and immunotoxic in Japanese quail, and provides evidence that the quail immune system may be fairly resilient to embryonic endocrine-disrupting chemical-induced alterations following no further exposure posthatch.

also tren's effects on the reproductive system and CNS are well documented:

Reproductive toxicity of trenbolone acetate in embryonically exposed Japanese quail.Quinn MJ Jr, Lavoie ET, Ottinger MA.
US Army Center for Health Promotion and Preventive Medicine, Directorate of Toxicology, Health Effects Research Program, Aberdeen Proving Ground, MD 21010, USA. [email protected]

This study was conducted to assess the effects of a one time embryonic exposure to trenbolone acetate on reproductive development and function in Japanese quail (Coturnix japonica). Embryos were exposed to either 0.05, 0.5, 5, or 50microg trenbolone or a sesame oil vehicle control at embryonic day 4. Onset of puberty, gonadal histopathology, sperm motility, cloacal gland size, and male copulatory behavior were assessed in adults. Trenbolone delayed onset of puberty in males, inhibited cloacal gland development, and reduced male reproductive behaviors. Industry laboratories have shown trenbolone acetate to be non-teratogenic in mammalian studies. Our study, however, shows that this one time in ovo exposure delayed onset of puberty in and suppressed adult copulatory behavior in quail males. These results suggest that this one time embryonic exposure to trenbolone may have disrupted development of either the central nervous system or the hypothalamic-pituitary-gonadal axis. This is the first study to demonstrate a demasculinizing effect on copulatory behavior in Japanese quail from embryonic exposure to a non-aromatizable androgenic chemical. More studies are needed to determine the mechanisms behind the observed effects.

PMID: 16989888 [PubMed - indexed for MEDLINE]

now while both of those studies were done on Japanese quail, its hard to find literature testing a substance like tren on humans (seeing as its not MEANT for human consumption). but even though these are extreme circumstances, it does show how POWERFUL and DANGEROUS this compound is. when introduced to a embryo, it caused problems with the CNS, reproduction, and the immune system. tren is NOTHING TO JOKE ABOUT.

its really hard to find a lot of literature concerning trenbolone because of its use in cattle (NOT HUMANS), but one can deduce from the experiences of those on these boards (the increased occurence of liver problems, serious side effects, etc.) and the studies done on trenbolone and how it effects these animals that tren is detrimental to your body. it is not worth the risks. it was said on PubMed that trenbolone is a KNOWN CARCINIGEN in vivo (sorry i lost the article, i promise it said that ). that means it causes cancer...

please guys....dont use tren. its not worth it, there are less toxic options that are a lot safer.

 

[navigatorrs]

Very good read

 

[SVFootball]

ok i just ordered a paper on trenbolone in humans, so ill see when i can get that and post it up for you guys.

 

[LEX]

what are the differences between tren and test in the same study?
that would be interesting to see or winny or anything else?

 

[bhumik]

Not that i dont agree that steroids are unhealthy.. Those studies are done on embryos. a lot of the stuff tht the human body can tolerate embryos cant cause they are developin like alcohol, smoking, etc. etc..

 

[SVFootball]

Not that i dont agree that steroids are unhealthy.. Those studies are done on embryos. a lot of the stuff tht the human body can tolerate embryos cant cause they are developin like alcohol, smoking, etc. etc..

yes they are done on embryos but they both still show the massive effects that tren can have and how potent it is. the embryos were administered VERY low dosages ONCE. bodybuilders put that chemical into their body multiple times over the course of their cycle. like i said before, these studies arent perfect and if you really look for problems you'll see them. tren is barely ever studied in humans seeing as its not intended for human use. most of the studies i can find are based on second-hand injestion from meat.

and lex, im gonna try to get some more research done tomorrow...i gotta be up early. ill get up that article on tren in humans as soon as i can. and hopefully ill be able to answer all your questions in detail tomorrow.

 

[LEX]

there is an argument to be made that anything giving durring that phase of development will do the same or just as bad as damage incuding uv light-and or any type of hormone durring the wrong time or slightly different dose than normal.
Not knocking the info just thinkin out loud here.

bhumik's point is a valid one.

thanks SV this is interesting.

 

[Pawwn]

The bad news:

Tren does make me sleep less...for whatever reason. It is the only thing to cause my ship to sail at half mast. After so many weeks on it, then getting off it, I felt much better and healthier.

The good news: Amazing muscle hardness and for me, major fat burning in the stomach area IF I watched the carbs. Improved vascularity and I appeared more cut. Great strength gains. No brown pee or kidney problems.

It is a great drug just like anything else...don't do too much for too long and MOST people will be fine.

 

[GoneForever]

On a side note. I find NPP to be far better than tren, and its pretty safe.

 

[Brutis]

damit

I just ordered 5 million viles of it.

 

[FastFrank]

2bigfred and most others with liver adenomas have used quite high doses of testosterone too. It is fairly well documented that it is actually high estrogen over time which cause liver adenomas. In this specific example of liver adenomas i would be more likely to put the blame on testosterone / dbol in most cases.

Kidney damnage from tren seems indirect. Tren causes dehydration, lack of sleep and increased bp, none of which are good for kidneys in the first place. With proper care, these can be taken care of.

Ive never head of tren causing tumors before? please tell more.

carcenigins are funny in that we are around them everyday, hell the plastic on your syringe is a very well known one, as well as soy products, tap water.

tren may be the most dangerous steroid, ive never ran it personally and am unsure on the future. I think this is a great thread to start SV and im not trying to argue with you, rather, bring up the other side of the discussion. There are alot of guys that have ran alot of tren out there for many years.

 

[brajosm]

damn it, i love tren

 

[trenbo12]

ive seen a picture of that quail its one BIG BIRD

 

[aesop]

ok so after the controversy brought up during 2BigFred's battle with his health, a lot of people on a couple boards im on have voiced their concerns about the virulent nature of trenbolone and how it is the most dangerous steroid available today. many ideas have been brought up pointing fingers at tren for causing tumors, liver adenomas, and other very serious health problems. ive decided that someone has to get the word out there and try to show how dangerous tren really is, so why not me.

first off, trenbolone is immunotoxic, as can be seen in the following abstract taken off PubMed:



also tren's effects on the reproductive system and CNS are well documented:



now while both of those studies were done on Japanese quail, its hard to find literature testing a substance like tren on humans (seeing as its not MEANT for human consumption). but even though these are extreme circumstances, it does show how POWERFUL and DANGEROUS this compound is. when introduced to a embryo, it caused problems with the CNS, reproduction, and the immune system. tren is NOTHING TO JOKE ABOUT.

its really hard to find a lot of literature concerning trenbolone because of its use in cattle (NOT HUMANS), but one can deduce from the experiences of those on these boards (the increased occurence of liver problems, serious side effects, etc.) and the studies done on trenbolone and how it effects these animals that tren is detrimental to your body. it is not worth the risks. it was said on PubMed that trenbolone is a KNOWN CARCINIGEN in vivo (sorry i lost the article, i promise it said that ). that means it causes cancer...

please guys....dont use tren. its not worth it, there are less toxic options that are a lot safer.

This doesn't show anything. Of course administering an extremely androgenic/anabolic substance directly to a developing embryo will fuck it up. So will pretty much any other hormone, Hormone levels of the developing embryo are mainly controlled by the placenta as the embryo develops administering any AAS is not going to have a positive benefit. When you only provide and abstract with know experimental design, results, outcomes etc you are basically posting an opinion and not truth.

I am not defending tren, it is a harsh drug but posting studies with zero correlation to your point does little to help your crusade. Post up the COMPLETE human study when you get it. Tren is a harsh drug, but I cant say that it is the one and only cause of problems as far as AAS goes. I think most of you guys are trying to justify your continued steroid use as "healthy" as long as you don't use tren. This of course is bullshit, and while some can take huge doses of AAS there whole life with zero side effects, others are not so lucky.. IMO using AAS consistently throughout your lifespan is akin to smoking it won't kill everyone early but the majority will notice a shortening of their lifespan.

 

[SVFootball]

This doesn't show anything. Of course administering an extremely androgenic/anabolic substance directly to a developing embryo will fuck it up. So will pretty much any other hormone, Hormone levels of the developing embryo are mainly controlled by the placenta as the embryo develops administering any AAS will severely is not going to have a positive benefit. When you only provide and abstract with know experimental design, results, outcomes etc you are basically posting an opinion and not truth.

I am not defending tren, it is a harsh drug but posting studies with zero correlation to your point does little to help your crusade. Post up the COMPLETE human study when you get it. Tren is a harsh drug, but I cant say that it is the one and only cause of problems as far as AAS goes. I think most of you guys are trying to justify your continued steroid use as "healthy" as long as you don't use tren. This of course is bullshit, and while some can take huge doses of AAS there whole life with zero side effects, others are not so lucky.. IMO using AAS consistently throughout your lifespan is akin to smoking it won't kill everyone early but the majority will notice a shortening of their lifespan.

i never said that these were the "end all" studies that mean that tren is horrible, im simply posting up what i can find. if you want to go buy all the articles feel free, but i personally dont have the money to spend buying these articles to try and help you guys out. ive stated previously that these tests were done on embryos so they cannot be taken at face value, but you still have to look deeper and see the true power of this compound. why are there very few studies of tren on humans? its NOT SAFE. its NOT MEANT FOR HUMAN CONSUMPTION. i dont know how much clearer i can make this. you arent going to find a study that says "we administered 100mg/tren acetate a day for 6 weeks to 50 test subjects....these were their health problems." researchers CANT DO THAT. its not safe or ethical.

i dont see anyone else posting up research that they've done on the subject or even attempting to find articles and medical literature proving what they say, so honestly i dont see how anyone can criticize me for posting up what i have. and if you read these they do go through the experimental design, observations, conclusions; they just aren't divided up neatly.

with that being said, the only reason im picking on tren is because it was brought up in the other thread on 2BigFred, BaldNazi, and HELLA SWOLE's health problems. i dont have time to research every compound and site studies and experiments concerning each one's problems, so i chose one that i thought most people would benefit from. ive read numerous times about guys using tren at high dosages for thier 2nd, 3rd, nth cycle. it was stated by a member here he was on 100mg/day YEAR ROUND. im trying to help show the negative nature of this drug and the true dangers of it. in no way am i trying to be anti-AAS, hell i wish i had the money right now. in no way am i trying to single out tren as the "end all" drug, they're all powerful hormones and all very dangerous. but IMO, based on medical literature ive gone over, tren is the most dangerous steroid out there. flat out. you dont want to believe it, fine. dont. im just trying to help.

fastfrank...

im not trying to say tren IS definitaly what caused those liver adenomas, personally i feel as though it was a combination of multiple things, primarily the use of high dosages of testosterone (increasing estrogen levels through aromatization), use of strong androgens (ie. tren), and a genetic predisposition to these health problems (something which cant be measured or pre-diagnosed).

now on the topic of trenbolone as a carcinigen, ive found other literature claiming that it is not:

The genotoxicity of trenbolone, a synthetic steroid.Richold M.
Huntingdon Research Centre, Cambs, England.

Trenbolone, a synthetic androgen is used as a growth promotant in animal husbandry. Because of its steroidal structure and properties it has been extensively evaluated in a series of in vitro and in vivo assays to assess its genotoxic and initiating properties. Both the parent molecule 17-beta-hydroxy-trenbolone and its metabolite 17-alpha-hydroxy-trenbolone, produced only in cattle, have been tested. 17-beta-hydroxy-trenbolone was not genotoxic in the Ames Salmonella/microsome assay, cytogenetics assays in human lymphocytes and CHO cells, a micronucleus assay in CHO cells, a DNA repair synthesis assay in HeLa cells, mammalian cell mutation assays with CHO and V79 cells, the mouse micronucleus assay, rat bone marrow or spermatogonial cytogenetics assays or in a test for initiators in the rat. In the mouse lymphoma cell mutation assay with L 5178Y TK+/- cells, equivocal responses were obtained, particularly at highly toxic concentrations. With 17-alpha-hydroxy-trenbolone a weak positive response was obtained in the L5178Y Tk +/- assay, particularly at highly toxic concentrations. Negative results were obtained in the Ames Salmonella/microsome assay, the cytogenetics assays using both human lymphocytes in vitro and rat bone marrow in vivo, the DNA repair assay and in the CHO mammalian cell mutation assay. It was also negative in the in vivo test for initiators. From this extensive battery of data, and also taking into account published data on trenbolone, it is concluded that 17-alpha-hydroxytrenbolone and 17-beta-hydroxy-trenbolone are devoid of genotoxic activity and are not initiators of cancer.

PMID: 3288174 [PubMed - indexed for MEDLINE]

so right now the whole "cancer-causing" argument is up in the air, some literature says it does, others say it doesnt. hopefully if i get that article it could help clear this up.

 

[BitsOBrawn]

It's not so much that tren is any worse for you than test or any other host of bodybuilding drugs we use. It's the high doses and combinations of shit. I mean I was reading the cycle of some guy on a board that is a 40 year old ex athlete. His cycle was like 5 different compounds. What a joke. If you can't grow off 500mgs of test a week and an oral it doesn't matter what brilliant cycle you come up with. Plus there is a lot of other shit floating around in steroids these days. You've got lab results with heavy metals, and shit like prednisone in them. 99% of the time unless you pay the extra money to have this shit specifically tested for you don't know if it's in there even if the steroid comes back as legit and pure. I think this blame tren bandwagon is a little premature and unscientific. I mean fuck grinding up pellets and making tren and injecting that into your body. Or even UG tren. That's crazy. Parabolan was an amazing steroid. But it was meant for human use.

 

[vadim_b1]

ok so after the controversy brought up during 2BigFred's battle with his health, a lot of people on a couple boards im on have voiced their concerns about the virulent nature of trenbolone and how it is the most dangerous steroid available today. many ideas have been brought up pointing fingers at tren for causing tumors, liver adenomas, and other very serious health problems. ive decided that someone has to get the word out there and try to show how dangerous tren really is, so why not me.

first off, trenbolone is immunotoxic, as can be seen in the following abstract taken off PubMed:



also tren's effects on the reproductive system and CNS are well documented:



now while both of those studies were done on Japanese quail, its hard to find literature testing a substance like tren on humans (seeing as its not MEANT for human consumption). but even though these are extreme circumstances, it does show how POWERFUL and DANGEROUS this compound is. when introduced to a embryo, it caused problems with the CNS, reproduction, and the immune system. tren is NOTHING TO JOKE ABOUT.

its really hard to find a lot of literature concerning trenbolone because of its use in cattle (NOT HUMANS), but one can deduce from the experiences of those on these boards (the increased occurence of liver problems, serious side effects, etc.) and the studies done on trenbolone and how it effects these animals that tren is detrimental to your body. it is not worth the risks. it was said on PubMed that trenbolone is a KNOWN CARCINIGEN in vivo (sorry i lost the article, i promise it said that ). that means it causes cancer...

please guys....dont use tren. its not worth it, there are less toxic options that are a lot safer.

Trenbolone was approved for human use which meant it underwent clinical trials proving its relative safety. (Im not saying its completely safe, but its not a toxin like youre portraying it)
Remember Negma parabolan?

So your argument fails ultimately.

 

[SVFootball]

Trenbolone was approved for human use which meant it underwent clinical trials proving its relative safety. (Im not saying its completely safe, but its not a toxin like youre portraying it)
Remember Negma parabolan?

So your argument fails ultimately.

who was it approved by? ive found no human studies on it...

point me in the right direction

and no, ive never heard of negma

 

[vadim_b1]

It was approved by a French organization which is analogous to the FDA in the US.
Negma is a French pharm company which produced and marketed Parabolan (tren hex) for human use in the 1980's. It was available as an anabolic to treat usual conditions for which anabolics are prescribed (i.e. muscle wasting, anaemia, treatment of burns).
Im sure youre aware that before any drug enters the market, it has to undergo years of trials beginning from trials on cell cultures, to animal testing and finally clinical trials. It can take up to 10 years for such process to complete.
There is info and studies, im too lazy to look for it, but im sure you can find it if youre interested.

Parabolan was unfortunately discontinued, however it was not due to its toxicity or side effects, but due to it being of limited use in clinical practice and extended use by bodybuilders, meaning most of it went on the black market.

However according to latest rumors, tren hex for human use will soon be again released by Genepharm (a greek pharm company).

 

[SVFootball]

It was approved by a French organization which is analogous to the FDA in the US.
Negma is a French pharm company which produced and marketed Parabolan (tren hex) for human use in the 1980's. It was available as an anabolic to treat usual conditions for which anabolics are prescribed (i.e. muscle wasting, anaemia, treatment of burns).
Im sure youre aware that before any drug enters the market, it has to undergo years of trials beginning from trials on cell cultures, to animal testing and finally clinical trials. It can take up to 10 years for such process to complete.
There is info and studies, im too lazy to look for it, but im sure you can find it if youre interested.

Parabolan was unfortunately discontinued, however it was not due to its toxicity or side effects, but due to it being of limited use in clinical practice and extended use by bodybuilders, meaning most of it went on the black market.

However according to latest rumors, tren hex for human use will soon be again released by Genepharm (a greek pharm company).

i did do some research and found about about Negma, but i havent been able to find the clinical trials. ill keep looking. im trying to show both sides here...i just posted up that abstract saying that a study showed that it did not cause cancer, and i have a whole article explaining in-depth why it doesn't and how everything was conducted. unfortunately i cant attach the article, it's too large.

i searched the FDA's website and found nothing about tren in humans, only through consumption of meat that had been exposed to it. nothing saying it was ever tested directly in humans, nor ever approved for human use. i dont know who approved it before, or where any of the clinical trials are. im not aware of how stringent the French version of the FDA is, so its not really a good comparison for me. i know the testing policies and procedures for getting a substance approved, and ill continue looking for the trials.

but to clarify here...do you feel as though tren is the most dangerous steroid?