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Understanding Post Cycle “T” Recovery

Crusader

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I recenly found this article. Hope it is helpful.

Understanding Post Cycle “T” Recovery
By William Llewellyn

O.K. You have been on an awesome 4-month cycle of Sustanon and Dianabol. You’ve gained a massive 20 lbs, and are extremely pleased with your results. You can’t stop looking in the mirror. But there is a problem now starting to eat away at you. You are going to run out of steroids very soon (you know you need a break anyway), and your testicles are the size of raisins. Your body is producing less testosterone than a 9-year-old girl, and you are scrambling to figure out what to do to avoid a nasty post-cycle crash that could potentially strip away some of your hard-earned muscle. The opinions on how to restore endogenous testosterone production post-cycle seem to be different everywhere you look. What option is best? Without an understanding of exactly what is going on in your body, and why certain compounds help to correct the situation, choosing the right post-cycle program can be quite confusing. In this article I would therefore like to discuss the role of anti-estrogens and HCG during this delicate window of time, while detailing an effective strategy for their use.

The Axis

The Hypothalamic-Pituitary-Testicular Axis, or HPTA for short, is the thermostat for your body’s natural production of testosterone. Too much testosterone and the furnace will shut off. Not enough, and the heat is turned up, to put it very simply. For the purposes of our discussion here we can look at this regulating process as having three levels. At the top is the hypothalamic region of the brain, which releases the hormone GnRH (Gonadotropin-Releasing Hormone) when it senses a need for more testosterone. GnRH sends a signal to the second level of the axis, the pituitary, which releases Luteinizing Hormone in response. LH for short, this hormone stimulates the testes (level three) to secrete testosterone. The same sex steroids (testosterone, estrogen) that are produced serve to counter-balance things, by providing negative feedback signals (primarily to the hypothalamus and pituitary) to lower the secretion of testosterone when too much of this hormone is sensed. Synthetic steroids, of course, suppress testosterone the same way. This quick background of the testosterone-regulating axis is necessary to furthering our discussion, as we need to first look at the underlying mechanisms involved before we can understand why natural recovery of the HPTA post-cycle is a slow process. Only then can we implement an ancillary drug program to effectively deal with it.

Testicular Desensitization & Post-Cycle LH Levels

Although steroids suppress testosterone production primarily by lowering the level of gonadotropic hormones discussed above, the big roadblock to a restored HPTA after we come off the drugs is surprisingly not the level of LH itself. This problem is made clearly evident in a study published in Acta Endocrinologica back in 1975(1). Here blood parameters, including testosterone and LH levels, were monitored in male subjects whom were given testosterone enanthate injections of 250mg weekly for 21 weeks. Subjects remained under investigation for an additional 18 weeks after the drug was discontinued. At the start of the study, LH levels became suppressed in direct relation to the rise in testosterone, which is to be expected. Things looked very different, however, once the steroids had been withdrawn (see Figure I). LH levels went on the rise quickly (by the 3rd week), while testosterone barely budged for quite some time. In fact, on average it was more than 10 weeks before any noticeable movement started. This lack of correlation makes clear that the problem in getting androgen levels restored is not the level of LH, but in fact testicular atrophy and desensitization to this hormone. After a period of inactivation the testes have apparently lost mass (atrophied), making them unable to perform the workload required by heightened levels of LH.

Post Cycle Testosterone Levels

Figure I. LH and Testosterone measurements starting 1 week after the last injection of 250mg of testosterone enanthate (pretreated measures were 5 mU/ml and 4.5 ng/ml respectively). Note that between weeks 1 and 5, as testosterone levels are declining due to the cessation of exogenous androgen administration, LH levels are already rebounding. From weeks 5 to 10 testosterone levels are at or very near baseline, to spite the substantial LH levels by this point. No significant increase in testosterone is noted until after the 10-week mark.

The Role of Anti-estrogens

It is important to understand that anti-estrogens alone do not do much to restore endogenous testosterone release after a cycle. Normally they only foster LH by blocking the negative feedback of estrogens, and we now see that LH rebounds quickly without help anyway. Plus, post cycle there is not an elevated level of estrogen for anti-estrogens to block, as testosterone (now suppressed) is a major substrate used for the synthesis of estrogens in men. Serum estrogen levels will actually be lower here as a result, not higher. Any estrogen rebound that occurs post-cycle likewise happens concurrently with a rebound in testosterone levels, not prior to it (note there is an imbalance in the ratio post cycle, but this is another topic altogether). We are seeing no mechanism in which anti-estrogenic drugs can really help here. We can see why this fact would not be difficult to overlook, however. The medical literature is filled with references showing anti-estrogenic drugs like Clomid and Nolvadex to increase LH and testosterone levels, and in normal situations these drugs do indeed increase endogenous androgen production by blocking the negative feedback of estrogens. Combine this with the fact that just as many studies can be found to show that steroid use lowers LH levels when suppressing testosterone, and we can see how easy it would be to jump to the conclusion that post-cycle we need to focus on restoring LH. We would miss the true problem of testicular desensitization unless we were really looking into the actual recovery rates of the hormones involved. When we do, we immediately see little value in using anti-estrogenic drugs.

HCG

So we now see, contrary to the dominating opinion of the times, that anti-estrogens alone will do little to raise testosterone levels in the early weeks of the post-cycle window. This leaves us to focus on a very different level of the HPTA in order to hasten recovery: the testes. For this we will need the injectable drug HCG. If you are not familiar with it, HCG, or Human Chorionic Gonadotropin, is a prescription fertility agent that mimics the bodies own natural LH. Although the testes are equally desensitized to this drug as LH (they both work through the same mechanism), we are administering it as a measured drug and are therefore not constrained by the limits of our own LH production. We similarly can use HCG to provide a bolus dose of LH (of our choosing), which works only to augment the recovering LH levels we already have in the body. In essence we are looking to shock them with an overwhelmingly high level of LH activity, coming from both endogenous and exogenous sources. We want it to reach a level far above what our body, even when supported by anti-estrogens, could possibly do on its own. The result can be a rapid restoration of original testicular mass and functioning, which would allow normal levels of testosterone to be output much sooner than without such an ancillary program. What we are looking at now is HCG actually being the pivotal post-cycle drug, while anti-estrogens are relegated to a supportive role at best.

Finalizing the Program

An ideal post-cycle recovery program will focus on two things really. The first is hitting the testes hard with HCG. It is important, however, not to overuse this drug. Taken for too long, or at too high a dosage, the LH receptor will actually become desensitized to LH(2) , which may further exacerbate our post-cycle problem instead of helping it (this is why I am not in favor of regular HCG use on-cycle). My experience with HCG has led me to feel comfortable using it for a course of three weeks, at a dosage of maybe 5000-7500IU weekly. Often the last week I limit the dose to 2,500IU, unless the cycle has been particularly long or potent. This is timed so at least half of the total administered drug dosage will be given when there is still exogenous steroid in the body. On our graph above this would be at about the 3-week mark after the last injection of testosterone. This will give the testes some time to get back into shape before the baseline is actually hit with T levels. Secondly, Anti-estrogens are used to play a supportive role at the same time, so 20mg of Nolvadex or 50-100mg of Clomid would typically be added ( my last article for Mind and Muscle discusses the comparative differences with these two agents). This is to combat the suppressive effects of estrogen as testosterone levels start to go back up, as well as potential side effects (HCG has been shown to increase testicular aromatase activity as well (3)). Although in the first couple of weeks the anti-estrogen does little, it may indeed be helpful when testosterone levels actually start to get back up near normal. To further stimulate the HPTA, and support continuingly high LH levels, the anti-estrogen remains to be used for 2 to 3 weeks after the HCG therapy has been stopped. A sample program, as it would be instituted in our sample post-cycle window, is provided below.

Sample Post-cycle Plan:

Week 3: 5000IU HCG total + 20mg Nolvadex daily
Week 4: 5000IU HCG total + 20mg Nolvadex daily
Week 5: 2500IU HCG total + 20mg Nolvadex daily
Week 6: 20mg Nolvadex daily
Week 7: 20mg Nolvadex daily
Week 8: 20mg Nolvadex daily


In Closing

I hope this article provided a well-needed new look at the mechanisms involved in post-cycle testosterone recovery. Indeed I believe it should debunk a commonly held belief these days, as we seen now that those advocating the sole use of Clomid post cycle are sorely missing the mark. The problem goes much deeper than just getting LH levels back. In fact, we see that LH doesn’t even need much help kicking back into gear, and a drug like Clomid will do very little to help this anyway in the absence of significant estrogen levels anyway. HCG is a drug with undeniable usefulness during the post-cycle window, and many bodybuilders have been much too quick to abandon it. It is truly fundamental to an effective recovery program, and would not consider any dose or combination of anti-estrogens or aromatase inhibitors capable of doing the job without it.
 

john thompson

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Too much?

It's my understanding that 500iu's of hcg per day for two weeks(abdominal injection) is all that's needed. and do you know whether intermuscular injection is just as good as sub inj? ...thanks
 

xcelbeyond

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Re: Too much?

john thompson said:
It's my understanding that 500iu's of hcg per day for two weeks(abdominal injection) is all that's needed. and do you know whether intermuscular injection is just as good as sub inj? ...thanks
I believe using it up to 1,000iu ED is ok. I also believe that using it "post-cycle" as described is just asking for gyno problems - hopefully the nolva will prevent it.

xcel
 

Crusader

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Nice questions.

I would read an article submitted by xcelbeyond: at this thread : http://www.professionalmuscle.com/forums/showthread.php?s=&threadid=1190. It will present to you yet another side of this issue. Here are my thoughts; 500 iu's sub-q HCG is sound IF you are not on anti-e's. I think, and my own experience bears this out, that though anti-e's do nothing for your natural Testosterone production, they do however help to prevent the aromatization of your test into an estrogen. The worry over estrogen as a result of 1 or 2000 IU's should be diminished significantly. I did try sub-q injections of 500 IU's a day. At the time I was not on anti-e's and therefore felt I needed to protect myself as best I could from estrogen. I personally would not take HCG without an anti-e.

To answer the question of wether IM is or is not as good Sub-q, and again this is from my personal experience, IM is faster and it seemed to work more completely. Sub-q's seemed slower to stimulate the Leydig cells of my testes and it did not seem to work, overall, as well. I make it a practice to have blood serum blood work to see where my hormone levels are. So this is only from my personal experience. Size and test production was too slow to recover and I did loose a little more muscle in the interim.
 
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john thompson

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im v sub inj

thanks crusader, anyone else want to chime in on whether to use hcg imm or sub inj?....condo
 

Crusader

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IM vr sub-q

I am glad this question was asked, and I think it is deserving of more study:

Which is best, Intramuscular or subcutaneous injections. I recently posted that I had better success with IM; but, Recently I've been studying about hMG. It's the sister to hCG. The M stands for Menopausal. It's used in men who have a low sperm count by stimulating the Leydig cells of the testes. There are two types of applications: IM and sub-q. Sub-q had a 58% greater effect. Being that these two hormones are so similar, the type and effectiveness of the type of injection should be looked into.

I would like to know the opinions and/or science of others here.
 

xcelbeyond

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What I'm about to throw out isn't science. dragonfire's doc told him to inject hcg sub-Q as it will help aid fat loss. I've never heard of this. Need to check with DF to see if it was effective.

xcel
 

Crusader

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fat reduction?

I find it difficult to believe but I have been shocked more often than not. I will be very interested in this one way or the other.

I would like to see more information on hMG as well.
 

Superior1

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HCG

For a while many said to use HCG @ 5000IU 2x's every 5 days.
I've used it that way. I have also used it at 1000IU ED for 10 days. And found it to be so much more effective. HCG is fast acting, and the 1000IU dosing scheme works much better than slamming yourself with 5000IU once and then again in 5 days.
This leads me to believe that HCG is best used Sub-Q for the sole pusposes of using a method that slows the action down as much as possible. There is not going to be a much of a difference between the two, But Sub-Q is probably going to be a bit more effective by slowing the action down to a point that works in a more natural or gradual state.
It can be compared with insulin for that matter. Not a HUGE difference between the two but there is a noticable one. I say use HCG Sub-Q for best results at no more than 1000IU daily for 10 days. If you choose to use 500IU that should be adequate. But 500IU 2x's daily is probably best. At least it would be for me.

Sup
 

Crusader

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HCG: Sub-Q or IM

Funny that I should see a response to this now. I've spent a good deal of money and travel time seeing perhaps one of the best medical doctors this area of medicine. He is well acquainted with my use of "supplements" to enhance my size and continues to work with me.

Sub-Q or IM ?? After four months of using me as a test monkey, Sub-Q at 5000 IU's (max) twice weekly was found to have the greatest results. Now he and his team are doing it again while I cycle. I'll post a response to that scheme later once I have some results. But for now, I am satisfied that Sub-Q does achieve far better results based on the weekly follow up test.

Oh yes, one more thing; there was no "down grading" of the Gonadotropin receptors in the testes as a result of four months of use. Some on other boards suggested this as a possibility.

Any questions with respect to details I will gladly answer.

Crusader
 

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