One cycle on test/tren/npp/drol (yeah thats a lot of progestins!) some lumps appeared and started flaring up. Was already on 20mg nolva/day, threw in 1mg/day of adex, as it worsened I upped the nolva all the way to 80mg/day to no avail. Went and got some B-6 and vitex from the local herb shop, I took 600mg/day of B-6 and I believe 2-3g/day of vitex. Stopped the gyno in its tracks in a couple days and shrunk the lumps back to normal. The only thing I have heard is high doses of B-6 for long periods of time can be hard on your nervous system, but I think you would have to go completely overboard on it for a VERY long period of time.