I think the most common one you are pointing out is the Brca gene for breast cancer, and the likelihood of one getting that increases exponentially with it and a relative being diagnosed. There are findings of linking it to a more aggressive prostate cancer too; which is 1 of the three most common forms of cancer men get
One of the strongest risk factors for prostate cancer is a family history of the disease. Germline mutations in the breast cancer predisposition gene 2 (BRCA2) are the genetic events known to date that confer the highest risk of prostate cancer (8.6-fold ...
www.ncbi.nlm.nih.gov
"Our results reveal that a wide spectrum of pathogenic mutations in the
BRCA1 and
BRCA2 genes confers a more aggressive PCa phenotype and these tumours are more frequently associated with lymph node involvement and distant metastasis at diagnosis than PCa in non-carriers."
One of our lecturers for cell bio and genetics in college was a cancer researcher at a large Midwest Uni. Me and some other students used to pick her brain after class on this topic, and probably the bigger thing she pointed out to a lot of us was the role of multiple drivers of cancer in each tumor, we know each cancer isn't the same classification, but each tumor is also a different cancer almost, and the drivers are scattered like the stars in these areas. She pulled up a diagram showing the linkage and it looked like a mutated Krebs cycle. Point being that she couldn't give an answer to the question of what's the biggest cause
NEJM:
I think it's pretty well studied that obesity is the biggest driver of cancer that's controllable by most people. People with diabetes also are at an increased risk, and poor outcomes. All that being equal, it's a role of dice for most of us in decent shape. Bodybuilders might not be obese from a body comp standpoint; but the other stuff done to create large amounts of muscle tissue isn't conducive to delaying dna damage either. And if it makes sense to eliminate any pro-prolif driver in later age, I'd do it personally. Just my thoughts on this