Damn when did you get your doctrine degree, you one smart dudeFirst, the majority of your acid secreting cells are your parietal cells in your gut. They have receptors for various molecules, espcially for histamine, acetylcholine and gastrin, all of which can stimulate gastric acid. The parietal cells serve as the target cells for inhibition. These targets are H2RA receptors. This is where drugs like Zantac come into play. They bind to the receptor and "turn it off".
These drugs are effective for the treatment of mild to moderate acid reflux and dyspepsia.
Prilosec OTC is another therapeutic option for treating patients with acid reflux. Prilosec targets the proton pump receptors also in your gut. So by combining the two drugs your are inhibiting two different forms of acid secreting portions of the gut cells.
Now, why only two weeks. The Prilosec often takes about 1 to 5 days to take effect ...........while the Zantac may take effect in an hour , so you are providing immediate relief.
The reason why the protocol requires 2 weeks is how long the prilosec take to work optimally. After 2 weeks your parietal cells are shut off due to allosteric inhibition, just a fancy way of saying those cells are not producing acid. This effect last about 4 months. Hence the 3-4 month cycle. The Zantac shuts off the gastric acid immediately while the Prilosec does it work and continues its effect for about 3 months.
Your doc may put you on Nexium....... 20 mg or 40 mg...... If your have erosive esophagitis he may require you take medication everyday. For reflux disease the usual requirement is daily for 4-8 weeks......... you may have a severe form of acid reflux.
First, the majority of your acid secreting cells are your parietal cells in your gut. They have receptors for various molecules, espcially for histamine, acetylcholine and gastrin, all of which can stimulate gastric acid. The parietal cells serve as the target cells for inhibition. These targets are H2RA receptors. This is where drugs like Zantac come into play. They bind to the receptor and "turn it off".
These drugs are effective for the treatment of mild to moderate acid reflux and dyspepsia.
Prilosec OTC is another therapeutic option for treating patients with acid reflux. Prilosec targets the proton pump receptors also in your gut. So by combining the two drugs your are inhibiting two different forms of acid secreting portions of the gut cells.
Now, why only two weeks. The Prilosec often takes about 1 to 5 days to take effect ...........while the Zantac may take effect in an hour , so you are providing immediate relief.
The reason why the protocol requires 2 weeks is how long the prilosec take to work optimally. After 2 weeks your parietal cells are shut off due to allosteric inhibition, just a fancy way of saying those cells are not producing acid. This effect last about 4 months. Hence the 3-4 month cycle. The Zantac shuts off the gastric acid immediately while the Prilosec does it work and continues its effect for about 3 months.
Your doc may put you on Nexium....... 20 mg or 40 mg...... If your have erosive esophagitis he may require you take medication everyday. For reflux disease the usual requirement is daily for 4-8 weeks......... you may have a severe form of acid reflux.