anyone see 60 minutes

[mrcat]

holy crap....some stuff they are using, called pixi dust, grows muscle. no kidding. it has worked in injured military men. It's likely years from the underground, but god just dream. Men that make Coleman look like a pencil neck, the future could be big, real big.........

 

[Oldlifter]

Hey bro, is there a link we can go too?.






.

 

[PHIL HERNON]

Question

Why would EVERYONE need to be huge? Humans have no NEED to be huge..it shortens life spans......no real advantage to it al all.........it is only for guys who quite frankly are insecure or needed to prevail in certain sporting events.......an edge.

 

[Magnum]

Why would EVERYONE need to be huge? Humans have no NEED to be huge..it shortens life spans......no real advantage to it al all.........it is only for guys who quite frankly are insecure or needed to prevail in certain sporting events.......an edge.

Yeah, I'm also wondering were I can get some.

 

[Thor]

HA HA

Why would EVERYONE need to be huge? Humans have no NEED to be huge..it shortens life spans......no real advantage to it al all.........it is only for guys who quite frankly are insecure or needed to prevail in certain sporting events.......an edge.

Leave it to our own Dr Phil to put things in perspective.

 

[BOOMSHAKER]

I think this is it.


YouTube - 'Pixie' dust helps finger grow

 

[Ruhlfreak55]

damn! that's some cool shit

 

[mrcat]

**broken link removed**

coming to the black market near you soon....

 

[tsimehc75]

Why would EVERYONE need to be huge? Humans have no NEED to be huge..it shortens life spans......no real advantage to it al all.........it is only for guys who quite frankly are insecure or needed to prevail in certain sporting events.......an edge.

lmao!!! you heard it here first..phil get your ass online tomm freak!!

 

[hawkmoon]

Why would EVERYONE need to be huge? Humans have no NEED to be huge..it shortens life spans......no real advantage to it al all.........it is only for guys who quite frankly are insecure or needed to prevail in certain sporting events.......an edge.

But...but...but...I like being big...

 

[Oldlifter]

Why would EVERYONE need to be huge? Humans have no NEED to be huge..it shortens life spans......no real advantage to it al all.........it is only for guys who quite frankly are insecure or needed to prevail in certain sporting events.......an edge.

Phil,

What bodyweight would you say is "too much" for one to carry that would shorten ones life span?





.

 

[Michaelthomasj]

It really really really disturbs me to see our military guys disfigured so badly..in that one video. Who ever is military here..thank you so much for all you guys and gals do. The government needs to do more to help our injured miltary personel. sorry to get off the topic, but i hate to see our men and women in that condition.

 

[builder]

+1

 

[Oldlifter]

It really really really disturbs me to see our military guys disfigured so badly..in that one video. Who ever is military here..thank you so much for all you guys and gals do. The government needs to do more to help our injured miltary personel. sorry to get off the topic, but i hate to see our men and women in that condition.

What's even sadder is the fact that the ones responsible for sending our loved ones (mother's, father's, brother's, sisters, etc.) into this mess could care-a-less how they come back. Whether it be ,dead, maimed, mentally ruined, etc.





.

 

[PHIL HERNON]

Oh man

Phil,

What bodyweight would you say is "too much" for one to carry that would shorten ones life span?





.

who knows.....no specific number.....I guess the number that you cant tie your shoes or shop without leaning on a counter after a few steps.....is a good place to start

 

[PHIL HERNON]

Hhhahahhahah

But...but...but...I like being big...

Honestly, your size is PLENTY....these guys want to be 300 pounds at 5'-5"

 

[Oldlifter]

who knows.....no specific number.....I guess the number that you cant tie your shoes or shop without leaning on a counter after a few steps.....is a good place to start

Haha! I can go with that. To continue. What is the life span of the sumo wrestlers? that should be a good indicator if to much bw is a factor in life span, eh?





.

 

[dece870717]

News article on this stuff **broken link removed**

 

[dragonfire101]

I posted study earlier this year about targeting ECM regulation and expression/signaling of Transforming growth factor-β1 (TGF-β1) in regards to helping people with muscular dystrophy. Believe it was Duchane's Muscular dystrophy because I have a child on my case load I was looking for clinical trials to try and help him.

The role of transforming growth factor beta-extracellular matrix signaling in skeletal muscle growth and development

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Title: The role of transforming growth factor beta-extracellular matrix signaling in skeletal muscle growth and development
Author: Li, Xuehui
Description: Muscle development is a highly organized process, regulated by interactions between muscle cells and their extracellular matrix (ECM) environment. The ECM through its regulation of growth factors plays a pivotal role in muscle growth and development. Transforming growth factor-β1 (TGF-β1) is a potent inhibitor of muscle cell proliferation and differentiation. Decorin, one of components in the ECM, binds to TGF-β1 and modulates muscle cell responsiveness to TGF-β1. The TGF-β1 signal is carried by Smad proteins into the cell nucleus, resulting in an inhibition of the expression of certain myogenic regulatory factors. In addition, TGF-β1 affects expression of cell β1 integrin adhesion receptor that is involved in cell adhesion and survival. However, the mechanism by which these factors interact and the signaling pathway is largely unknown. To address this mechanism, both in vitro and in vivo studies were preformed. In vitro studies showed that TGF-β1 reduced both decorin and β1 integrin expression, and altered the localization of β1 integrin in satellite cells. Decorin plays a negative role in the TGF-β1-dependent signaling pathway in terms of inhibiting satellite cell responsiveness to TGF-β1, resulting in enhanced cell proliferation and differentiation. Decreased expression of β1 integrin is likely involved in the programmed cell death or apoptotic effect of TGF-β1 on muscle cells through regulating focal adhesion kinase signaling pathway. The expression of myogenic regulatory factors, MyoD and myogenin, was inhibited by TGF-β1 through Smad3-mediated pathway, resulting in decreased satellite cell proliferation and differentiation. In vivo studies investigated the function of TGF-β1 on the expression and localization of β1 integrin and decorin during muscle formation by injection of TGF-β1 into the developing chicken embryo. In addition, the muscle cells from Low Score Normal (LSN) chicken, genetic muscle weakness, showed a different cellular responsiveness to TGF-β1 compared to the normal, which suggests a complex mechanism involved in the LSN condition. This study provides new information on the role of the TGF-β1-ECM signaling pathway in muscle growth and development, which will not only be critical to the domestic animal industries, but also benefit human health in terms of the repair and regeneration of muscle with age.

 

[dragonfire101]

Before anyone goes playing with some ECM modifier that comes out that it can do other things besides signal to grow muscle tissues specifically.

Conf Proc IEEE Eng Med Biol Soc. 2009;1:3350-2.

Cell-matrix mechanobiology: Applications to brain tumors and design of tissue engineering scaffolds.

Kumar S.

Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720 USA.

It is becoming increasingly clear that mechanical and other biophysical signals from the extracellular matrix (ECM) can powerfully influence a wide variety of fundamental cell behaviors, including proliferation, differentiation, death, and motility. This concept has significant implications both for understanding the pathophysiology of disease and the design of biointerfaces found in cellular microdevices and tissue engineering platforms. Here we briefly review recent progress from our laboratory in investigating the role of ECM-derived mechanical signals in the specific context of two systems: The growth and spread of malignant brain tumors and the design of microscale cardiac tissue engineering systems. In both cases, mechanical signals encoded in the ECM govern motility, mechanics, and/or proliferation in profound and unexpected ways and rely upon the cell's reciprocal ability to generate contractile force through myosin and its molecular regulators.