Aromatase Inhibitor Cream?

[megarips250]

Has anyone ever heard of an AI cream that you can use locally on the affected area so you don't have to kill your E completely to get rid of your gyno?

 

[heavyhitter]

These have been around for awhile. Transdermal ai's do work....but I don't think I buy that they would work locally and more than a transdermal steroid would only increase muscular growth in a localized fashion

 

[Deleted member 121863]

Estrogen binds to receptors in tissues, there is blood flow in that same tissue, which means any ai that made it to receptors via transdermal cream would go systemic which happens very fast.


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[Matsuo Munefusa]

transdermal AIs don't make a whole lot of sense biologically to me....


transdermal SERMs on the other hand make a lot of sense to me! :headbang:

 

[Whey2Heavy]

transdermal AIs don't make a whole lot of sense biologically to me....


transdermal SERMs on the other hand make a lot of sense to me! :headbang:

Why...? If transdermal application somehow made SERMs even more selective, don't you think pharma would have tried that by now?