B6 for Progesterone

[bigraf]

Any validity behind running b6 along side tren or deca to keep prog in check?

 

[animal eater]

That along side vitex worked well for me.

 

[EasyEJL]

my understanding was that the B6 (specifically using P-5-P) was for prolactin control rather than progesterone.

When a woman who had a stillborn child or has an infant die and wants to stop lactating, the doctors will often give them 600mg of b6 a day for a week, and it stops lactation.

 

[bigpapa]

NOW Foods makes P-5-P which is great, ive used it many times. also vitex is good for this and bulk 1-carboxy helps with this as well as sleeping issues that may arise with tren use.

 

[Macro]

high dose b-6 or p5p are generally not effective with either trenbolone or nandrolone.

and there are negatives to high dosing these b-vitamins, including downregulation of androgen receptor and lesser down regulation of PgR and ER. So even for those it may work for, its probably not the best idea.


1: FASEB J. 1994 Mar 1;8(3):343-9. Links
Modulation of steroid receptor-mediated gene expression by vitamin B6.Tully DB, Allgood VE, Cidlowski JA.
Department of Physiology, University of North Carolina at Chapel Hill 27599-7545.

Gene transcription mediated by steroid hormones has become one of the most extensively characterized model systems for studying the regulation of gene expression in eukaryotic cells. However, specific details of gene regulation by steroid hormones are often complex and may be unique in specific cell types. Diverse regulatory mechanisms leading to either activation or repression of particular genes frequently involve interactions between steroid hormone receptors and other ubiquitous and/or cell-specific transcription factors that act on the complex promoter of the regulated gene. Interplay between steroid receptor-mediated and other signal transduction pathways may also be involved. In addition, recent novel results indicate that moderate variations in the intracellular concentration of pyridoxal 5'-phosphate (PLP), the biologically active form of vitamin B6, can have pronounced modulatory effects on steroid-induced gene expression. Specifically, elevation of intracellular PLP levels leads to decreased transcriptional responses to glucocorticoid, progesterone, androgen, or estrogen hormones. Conversely, cells in a vitamin B6-deficient state exhibit enhanced responsiveness to steroid hormones. One aspect of the mechanism by which these transcriptional modulatory effects of PLP occur has recently been shown to involve interruption of functional interactions between steroid hormone receptors and the nuclear transcription factor NF1. These findings--that the vitamin B6 nutritional status of cells modulates their capacity to respond to steroid hormones--impose an additional level of cell-specific control over steroid hormone regulation of gene expression and will serve as the focal point for this review.

 

[musicmann89]

L-dopa

 

[Macro]

L-dopa

l-dopa produces inconsistent suppression with subsequent elevation.

 

[musicmann89]

l-dopa produces inconsistent suppression with subsequent elevation.

250mg eod works fine without that problem, also vitex works well

 

[Macro]

250mg eod works fine without that problem, also vitex works well

that may work for you, which likely means that you dont actually have prolactin issues or at least insignificant ones.

because l-dopa admin does cause the "swing".

Vitex is not particularly effective, except in women where it may increase progesterone synthesis and/or modulate ER activation via Serm like ER action.

 

[musicmann89]

that may work for you, which likely means that you dont actually have prolactin issues or at least insignificant ones.

because l-dopa admin does cause the "swing".

Vitex is not particularly effective, except in women where it may increase progesterone synthesis and/or modulate ER activation via Serm like ER action.

havent seen anything about a "swing" do you have a study done on it ?

 

[Macro]

havent seen anything about a "swing" do you have a study done on it ?

Biology of Reproduction, Vol 13, 223-227, Copyright © 1975 by Society for the Study of Reproduction

Effect of L-dopa on Nocturnal Prolactin Surges During Pseudopregnancy
SHIAO-CHING HSUEH 1, and JAMES L. VOOGT 1

1 Department of Physiology and Biophysics University of Louisville Health Sciences Center Louisville, Kentucky 40201




Rats were made pseudopregnant by cervical stimulation during late proestrus or early estrus, and were cannulated via the right carotid artery several days later. A pattern of prolactin secretion during pseudopregnancy was found in which there were two daily surges of prolactin. Prolactin levels in the plasma reached a peak between 0100-0500 h (nocturnal peak) and 1700-1900 h (diurnal peak). Injection of L-dihydroxyphenylalanine (L-dopa) intraperitoneally at 0030 h on days 5-8 of pseudopregnancy initially suppressed prolactin secretion, compared to control pseudopregnant rats injected with the vehicle. This inhibition of prolactin was followed by a surge of prolactin between 0300-1700 h. When two injections of L-dopa were given at 0030 and 0230 h, prolactin levels were 10-15 percent of the controls at 0100 and 0300 h. However, at 0500-0700 h, there was a significant rebound effect; the concentration of prolactin in the plasma was then 12 times higher in rats which were treated with L-dopa than in controls. In none of the treated groups was there a significant change in the duration of pseudopregnancy. Thus, temporary inhibition of the nocturnal prolactin surge did not alter maintenance of pseudopregnancy.

 

[musicmann89]

Biology of Reproduction, Vol 13, 223-227, Copyright © 1975 by Society for the Study of Reproduction

Effect of L-dopa on Nocturnal Prolactin Surges During Pseudopregnancy
SHIAO-CHING HSUEH 1, and JAMES L. VOOGT 1

1 Department of Physiology and Biophysics University of Louisville Health Sciences Center Louisville, Kentucky 40201




Rats were made pseudopregnant by cervical stimulation during late proestrus or early estrus, and were cannulated via the right carotid artery several days later. A pattern of prolactin secretion during pseudopregnancy was found in which there were two daily surges of prolactin. Prolactin levels in the plasma reached a peak between 0100-0500 h (nocturnal peak) and 1700-1900 h (diurnal peak). Injection of L-dihydroxyphenylalanine (L-dopa) intraperitoneally at 0030 h on days 5-8 of pseudopregnancy initially suppressed prolactin secretion, compared to control pseudopregnant rats injected with the vehicle. This inhibition of prolactin was followed by a surge of prolactin between 0300-1700 h. When two injections of L-dopa were given at 0030 and 0230 h, prolactin levels were 10-15 percent of the controls at 0100 and 0300 h. However, at 0500-0700 h, there was a significant rebound effect; the concentration of prolactin in the plasma was then 12 times higher in rats which were treated with L-dopa than in controls. In none of the treated groups was there a significant change in the duration of pseudopregnancy. Thus, temporary inhibition of the nocturnal prolactin surge did not alter maintenance of pseudopregnancy.

awesome info never have seen this study before thanks!

 

[Ashop]

That along side vitex worked well for me.

I have heard of the B6 before,,but not familar with the Vitex.