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Dosage of arimidex/letrozole effect estrogen suppression?

thewizkid

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Hey
I read some studies of different doses of letrozole and arimidex suppressing estrogen the same, percentage wise. There was no difference in the amount of estrogen suppressed.

Anyone have experience with this? And is it true?
 

trekrider215

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Do you know what dosages of each they used to make them equal was? Or are you saying for example 1mg of arimidex and 1mg of letro resulted in the same estrogen suppression?
 

thewizkid

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Do you know what dosages of each they used to make them equal was? Or are you saying for example 1mg of arimidex and 1mg of letro resulted in the same estrogen suppression?


I actually mean that different dosages of the Aromatase inhibitor caused the same suppression on estrogen.
For example 0.5mg letrozole, 1mg letrozole, 2.5mg letrozole all caused the same percentage of estrogen suppression.
So if the persons estrogen was say 50pg/ml, their estrogen would be suppressed to the same amount regardless of the dosage. Let’s say to 15pg/ml
 

bad rad

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Letro is overdosed by most men. I can't take more than a 1/4 tab (.625mg) without crushing my E2. On 600mg Test my E2 was about 11 pg/mL.
 

thewizkid

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Letro is overdosed by most men. I can't take more than a 1/4 tab (.625mg) without crushing my E2. On 600mg Test my E2 was about 11 pg/mL.
There was the same studies with arimidex as well

0.5mg and 1mg of arimidex showed no difference in estrogen suppression in men. It was the same percentage of estrogen that was suppressed with both dosages
 

mario2901

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This study sounds like a bunch of...poop. Do you have a link?

Letro will crash your estrogen vs easily - so maybe that's what you saw..you can't be "negative" on bloodtest for estradiol.
 

MyNameIsJeff

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https://www.ncbi.nlm.nih.gov/m/pubmed/10902781/


0.5mg and 1mg arimidex suppressing estradiol the same in men
In men, there are 2 sources of serum estradiol: 1) aromatization from testosterone an 2) direct production of estrogen in testes and adrenal glands

In men, ~15% of circulating estrogens derive directly from testicular production with the remainder generated from androgens through peripheral activity of the enzyme aromatase.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835337/#S2title

Hence, the finding that 0.5mg and 1mg of arimidex lower serum estradiol by the same amount implies that both doses completely wipe out aromatase activity. The reason that serum estradiol is only lowered by ~50% is that the body still maintains the direct production of estrogen, mainly in the testes. In fact, estrogen-suppression will, via the HPTA, increase gonadotropins and with it estrogen production, thereby partially offsetting the effects of aromatase inhibition.

It's important to note that this partial suppression of estradiol will only happen in naturals. If you completely suppress your HPTA axis by injecting AAS, then this will also largely shut down estrogen production in the testes. In that case an AI dose such as 0.5mg arimidex can lower serum estradiol levels by almost 100%.

The take away here should be that we cannot infer from studies on naturals how much a given dose of AI will lower estradiol levels in AAS users. The same dosage of AI that will lower E2 by 50% in naturals may well completely tank E2 in AAS users.
 

fitzchivalry

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In men, there are 2 sources of serum estradiol: 1) aromatization from testosterone an 2) direct production of estrogen in testes and adrenal glands


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835337/#S2title

Hence, the finding that 0.5mg and 1mg of arimidex lower serum estradiol by the same amount implies that both doses completely wipe out aromatase activity. The reason that serum estradiol is only lowered by ~50% is that the body still maintains the direct production of estrogen, mainly in the testes. In fact, estrogen-suppression will, via the HPTA, increase gonadotropins and with it estrogen production, thereby partially offsetting the effects of aromatase inhibition.

It's important to note that this partial suppression of estradiol will only happen in naturals. If you completely suppress your HPTA axis by injecting AAS, then this will also largely shut down estrogen production in the testes. In that case an AI dose such as 0.5mg arimidex can lower serum estradiol levels by almost 100%.

The take away here should be that we cannot infer from studies on naturals how much a given dose of AI will lower estradiol levels in AAS users. The same dosage of AI that will lower E2 by 50% in naturals may well completely tank E2 in AAS users.
Exactly. Great post with thorough explanation.
 

thewizkid

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In men, there are 2 sources of serum estradiol: 1) aromatization from testosterone an 2) direct production of estrogen in testes and adrenal glands


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835337/#S2title

Hence, the finding that 0.5mg and 1mg of arimidex lower serum estradiol by the same amount implies that both doses completely wipe out aromatase activity. The reason that serum estradiol is only lowered by ~50% is that the body still maintains the direct production of estrogen, mainly in the testes. In fact, estrogen-suppression will, via the HPTA, increase gonadotropins and with it estrogen production, thereby partially offsetting the effects of aromatase inhibition.

It's important to note that this partial suppression of estradiol will only happen in naturals. If you completely suppress your HPTA axis by injecting AAS, then this will also largely shut down estrogen production in the testes. In that case an AI dose such as 0.5mg arimidex can lower serum estradiol levels by almost 100%.

The take away here should be that we cannot infer from studies on naturals how much a given dose of AI will lower estradiol levels in AAS users. The same dosage of AI that will lower E2 by 50% in naturals may well completely tank E2 in AAS users.
Thanks for clearing that up
 

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