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Initial studies suggest these may decrease cystatin C:
For example, in a study that followed over 1.9k seniors (>70) over 11 years, lower cystatin C was associated with a higher risk of developing Alzheimer’s disease, independently of age, APOE4 genotype, diabetes, and other risk factors. A 0.1-μmol/L decrease of cystatin C between ages 70 and 77 was associated with a 29% higher risk of incident Alzheimer’s disease [98].
Low Cystatin C
Causes
Causes shown below have been associated with low cystatin C. Work with your doctor or another health care professional to get an accurate diagnosis. Your doctor will interpret this test, taking into account your medical history, symptoms, and other test results.Initial studies suggest these may decrease cystatin C:
- Hypothyroidism [44, 45, 46, 92]
- Prolonged broadband noise exposure (e.g. from jet engines) [93]
- Kawasaki disease (blood vessel inflammation in children) [94]
- Neuromyelitis optica spectrum disorders (inflammatory disorders of the nervous system) [95]
- Bladder cancer [96]
- Genetics [97, 53]
Low Cystatin C in Disease
Lower cystatin C levels have been associated with a higher risk of:- Cognitive dysfunction and Alzheimer’s disease [4, 97, 98]
- Hardening of the arteries (atherosclerosis) [13, 9]
- Aneurysms [13, 99]
For example, in a study that followed over 1.9k seniors (>70) over 11 years, lower cystatin C was associated with a higher risk of developing Alzheimer’s disease, independently of age, APOE4 genotype, diabetes, and other risk factors. A 0.1-μmol/L decrease of cystatin C between ages 70 and 77 was associated with a 29% higher risk of incident Alzheimer’s disease [98].