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GH Scheme: Prevent suppression of GH secretion and sensitivity

TrenE

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Newbies
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Sep 2, 2020
Messages
4
Hello,

Taking GH ED vs EOD in terms of preventing suppression of own GH secretion and sensitivity to it was discussed often here based on the below study. The study shows that EOD group immediately after treatment returned to the values (growth rate) that were present before the study began. In the ED group a recovery of these values takes about 2 years.

EOD seems beneficial over ED to prevent this suppression. But I assume EOD is disadvantageous regarding fat loss (but not for bulking).

What is the current state of knowledge to use GH effectively with focus of fat loss/lean bulk and prevent suppression of own GH production and sensitivity after withdrawal?

What do you think about using GH 5on2off profiting more days from fat loss effects but also prevent suppressing effects on own GH secretion? I could not find a study which researchs suppressing effects on 5on2 compared to EOD or ED.

Thank you.

[...]Everyday injections seems to drastically lower your body's sensitivity to it's own GH secretion. The study included children with idiopathic short stature, but can be ever casting on us, normal non-deficient hGH individuals who may use hGH periodically for bodybuilding, sports and health purposes.
[...]
You can read the full article with all the graphs and details here:
Prevention of Growth Deceleration after Withdrawal of Growth Hormone Therapy in Idiopathic Short Stature
 

b_cornelius

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Jul 25, 2012
Messages
1,490
Ummm, all those GH secretagogues will do the trick. And/Or you could focus on lowering the negative feedback mechanisms, somatostatin, etc. Once you get the feedback under control, a solid dose of GHRH with a GHRLN analogue can kick start your pituitary. Similarly, one shot of GnRH kick-starts gonadotropins after steroid use. Some times, it has been found that it it necessary to administer the releasing hormones monthly as a legitimate therapy.
 

TrenE

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Sep 2, 2020
Messages
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Hello, are there any new findings about this topic?

I am still not sure if 5on/2off vs ed is beneficial in terms of avoiding suppression of endogenous HGH production.
GHRH's are the ones you wanna be concerned about when it pertains long term use, it's not exogenous HGH you really wanna be concerned about, it's more about the extensive and abusive use of GHRH's that "could" result in pituitary damage and such..
It's not comparable. The suppressive effect of exogenous GH on endogenous production is much more short lived. Roughly 24h after your last GH shot, your endogenous production is starting to recover. So short term use of GH will not lead to problems with GH secretion years later. As for continuous use of GH for years on end, we don't know for certain. There are no studies looking at what happens when healthy individuals abuse high doses of GH for years and then come off. I suspect that your natural production will kick back in even after a long time of using exogenous GH. Worst case, you have to take GH replacement therapy in your old age, not the end of the world. You'll probably want to do that anyway since GH secretion decreases rapidly with age.
 

pickapeck

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Nov 28, 2007
Messages
982
My IGF-1 dropped more than 30% after GH use and with CJC1295 DAC in place several months after GH use.
 

TrenE

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Sep 2, 2020
Messages
4
Which GH protocol did you use and for how long?

When did your IGF-1 level recover?
 

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