hGH + Metformin: A Good Thing. (Metformin does not lower, but rather increases IGF-1)

[opietaylor]

You don’t use any insulin?

nope. i dont like it. and my FBG is very good so no need.

 

[juicenstein]

It seems that bioavailability is very low, BUT i used it and seems working well, not like Metformin but it helps.

Hard to compare a drug vs a supplement.... Drugs work always better.

exactly ..U think everybody on this board would know that being we are all on AAS and not test boosters from GNC lol ...

 

[IronVtwin]

That's well and good, but Metformin is still an AMPK agonist and therefore will decrease mTOR signaling with or without the extra of igf1.

 

[Type-IIx]

That's well and good, but Metformin is still an AMPK agonist and therefore will decrease mTOR signaling with or without the extra of igf1.

True, if the practical purpose of rhGH is increased skeletal muscle mass (and the dosages to support it) then Insulin makes more sense. However, if the practical purpose is (or if the user is limited by dosage) lipolysis and maintenance of muscle mass, anti-aging, collagen synthesis, cognitive benefits, cardiorespiratory endurance, bone density (with long-term administration), et cetera, then Metformin makes more sense.

 

[Type-IIx]

BTW, while it may be clear to @IronVtwin, I'd be wary of coming to conclusions, almost always from in situ cancer cell lines, which behave remarkably differently from healthy human physiology.

 

[aphextwin]

I've read that metformin can kill sex drive, anyone concur or disagree with that one?

I disagree based on my experience. Like I mentioned before, never heard anyone complain about their sex drive while using the drug.

 

[aphextwin]

As you can tell, I’m pro metformin.