(HMG) Human Menopausal gonadotrophin

Fullybuilt · Mar 30, 2005

Has anyone used this during pct with HCG? Anyone know anyone who's used it. Its supposed to be better than HCG and a few pharmacies sell it online. A brand named "Pergonal" makes it, but all the pharms that sell it are euro,etc...kinda shady. Im in the middle of a pretty heavy 20weeker and i'd like to freeze some sperm when im done since I plan on staying on for life after this PCT and I figure a proper pct with the addition of HMG(supposed to bring back sperm count) would be what im looking for. So any info is appreciated. Thanks

Snarf · Mar 30, 2005

Pergonal is simply LH (leutinizing hormone) and FSH (Follicle stimulating hormone) combined. It is derived from the urine of pregnant women.

HCG (human chorionic gonadotropin), also from women's pee, mimics the activity of LH.

Your goal in PCT is to get your testosterone production back up and running. This is mediated by your Leydig cells in your testes. Leydig cells contain LH receptors which stimulates testosterone production. So, for getting your test back up, you really only need HCG.

However, if you are worried about sperm production, there might be some merit to using Pergonal, beacuse the FSH binds to/stimulates Sertoli cells in the testes which more directly impacts sperm production.

The problem is that if you use Pergonal, you are supplementing with exogenous FSH and this will tell your pituitary that you don't need to make any more. So, your testes might start making some sperm, but you really havn't recovered your HPTA.

I still strongly believe in using HCG DURING your cycle in low weekly doses so your testes are never shut down. When you hit PCT, you can continue moderate HCG dosing and wait for your natural LH and FSH to rebound.

Blasting your Leydig cells with massive HCG doses (5,000IU +) periodically is just asking for primary hypogonadism. If you insist on doing HCG this way, make sure you take some Nolvadex at the same time. This has been shown to limit the reduced Leydig cell sensitivity to HCG.