little slice
Featured Member / Kilo Klub
- Joined
- Mar 3, 2014
- Messages
- 12,604
http://www.demneuropsy.com.br/imageBank/PDF/dnv01n04a01.pdf
Below is the conclusion of the study (basically a TL;DR)
Conclusion
The effects of DNP in the prevention of neurotoxicity
and aggregation of β-amyloid, promotion of neurite
outgrowth and neuronal differentiation reviewed above
suggest that DNP should be explored as a lead compound
for the development of novel therapeutic approaches for
AD and, possibly, for other devastating and as yet incurable
neurological disorders. Nevertheless, considering its
well-known toxicity, it is important to emphasize that it is
not our intention to propose that DNP (even at low doses)
should be re-introduced into clinical practice without more
research and, in particular, a re-evaluation of its toxicological
profile at low doses. We believe that a compound such
as DNP, simultaneously able to target amyloid aggregation
and to reinforce the neuronal network, may find use in the
management and treatment of AD. Moreover, mild mitochondrial
uncoupling by low doses of DNP may also be
of benefit in a range of neurological disorders in which
excitotoxicity and oxidative stress play major roles. Finally,
the ability of DNP to stimulate neurite outgrowth and neuronal
differentiation may also be of interest in strategies
aimed to stimulate nerve regeneration.
Below is the conclusion of the study (basically a TL;DR)
Conclusion
The effects of DNP in the prevention of neurotoxicity
and aggregation of β-amyloid, promotion of neurite
outgrowth and neuronal differentiation reviewed above
suggest that DNP should be explored as a lead compound
for the development of novel therapeutic approaches for
AD and, possibly, for other devastating and as yet incurable
neurological disorders. Nevertheless, considering its
well-known toxicity, it is important to emphasize that it is
not our intention to propose that DNP (even at low doses)
should be re-introduced into clinical practice without more
research and, in particular, a re-evaluation of its toxicological
profile at low doses. We believe that a compound such
as DNP, simultaneously able to target amyloid aggregation
and to reinforce the neuronal network, may find use in the
management and treatment of AD. Moreover, mild mitochondrial
uncoupling by low doses of DNP may also be
of benefit in a range of neurological disorders in which
excitotoxicity and oxidative stress play major roles. Finally,
the ability of DNP to stimulate neurite outgrowth and neuronal
differentiation may also be of interest in strategies
aimed to stimulate nerve regeneration.