It is all about balance. Our endocrine systems are very finely tuned to run a certain way. Just enough test, just enough estrogen, just enough thyroid etc. Once you start upsetting that balance with exogenous hormones and chemicals then something is going to suffer. Plain and simple. trying to find the absolute best balance is essential. This is why body building is never an exact science. Too many variables that can change the outcomes. SO you will have to perservere with things until ou get it right. It is, simply put, the price we all pay for our minds wanting the extra size our bodies do not want.