.gif "IP Gear")
- Joined
- Mar 26, 2008
- Messages
- 2,123
Hello folks, I am looking for an answer. I am currently using Tren and of course Cabergoline on the side to prevent any prolactin from rising. Now, from what I know about Cabergoline, it is also a dopamine agonist.
Taken from “Wiki”
Pharmacology
Although cabergoline is commonly described principally as a dopamine D2 receptor agonist, it also possesses significant affinity for the D3,D4, 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, α2B- receptors, and moderate/low affinity for the D1 and 5-HT7 receptors. Cabergoline functions as an agonist at all receptors except for 5-HT7 and α2B-, where it acts as an antagonist.[2
I am going to a concert this weekend, and it’s a once in a year type of thing , and as a tradition, we will be “using” some Psilocybin. I do it once a year and I have a blast every time.
Taken from “Wiki”
Psilocybin is rapidly dephosphorylated in the body to psilocin, which then acts as a partial agonist to several receptors involved with theneurotransmission of serotonin. Psilocin has a high affinity for the 5-HT2A serotonin receptor in the brain, where it mimics the effects of serotonin (5-HT). Psilocin binds less tightly to other serotonergic receptors 5-HT1A, 5-HT1D, and 5-HT2C.[8] Serotonergic receptors interact withpyramidal neurons in the cerebral cortex, which are thought to be involved in the perception of pain and anxiety.[62] The psychotomimeticeffects of psilocin can be blocked in a dose-dependent fashion by the 5-HT2A antagonist drugs ketanserin and risperidone.[63] Although the 5-HT2A receptor is responsible for most of the effects of psilocybin, various lines of evidence have shown that interactions with non-5-HT2Areceptors also contribute to the subjective and behavioral effects of the drug.[64]
Psilocybin and analogs of psilocybin have been used to help model the structure and function of the 5-HT2C G-protein-coupled receptor.[65][66]In contrast to LSD, psilocybin and psilocin have no affinity for the dopamine D2 receptor.[8
My question is, is there any risk to taking a dopamine agonist combined with Psilocybin? Will it enhance its effects, weaken its effects? Or have any type of harmful effects?
I know recreational drug use talk is prohibited on this board, and if this type of question is in violation of the forum rules, please forgive me and delete this thread.
Taken from “Wiki”
Pharmacology
Although cabergoline is commonly described principally as a dopamine D2 receptor agonist, it also possesses significant affinity for the D3,D4, 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, α2B- receptors, and moderate/low affinity for the D1 and 5-HT7 receptors. Cabergoline functions as an agonist at all receptors except for 5-HT7 and α2B-, where it acts as an antagonist.[2
I am going to a concert this weekend, and it’s a once in a year type of thing , and as a tradition, we will be “using” some Psilocybin. I do it once a year and I have a blast every time.
Taken from “Wiki”
Psilocybin is rapidly dephosphorylated in the body to psilocin, which then acts as a partial agonist to several receptors involved with theneurotransmission of serotonin. Psilocin has a high affinity for the 5-HT2A serotonin receptor in the brain, where it mimics the effects of serotonin (5-HT). Psilocin binds less tightly to other serotonergic receptors 5-HT1A, 5-HT1D, and 5-HT2C.[8] Serotonergic receptors interact withpyramidal neurons in the cerebral cortex, which are thought to be involved in the perception of pain and anxiety.[62] The psychotomimeticeffects of psilocin can be blocked in a dose-dependent fashion by the 5-HT2A antagonist drugs ketanserin and risperidone.[63] Although the 5-HT2A receptor is responsible for most of the effects of psilocybin, various lines of evidence have shown that interactions with non-5-HT2Areceptors also contribute to the subjective and behavioral effects of the drug.[64]
Psilocybin and analogs of psilocybin have been used to help model the structure and function of the 5-HT2C G-protein-coupled receptor.[65][66]In contrast to LSD, psilocybin and psilocin have no affinity for the dopamine D2 receptor.[8
My question is, is there any risk to taking a dopamine agonist combined with Psilocybin? Will it enhance its effects, weaken its effects? Or have any type of harmful effects?
I know recreational drug use talk is prohibited on this board, and if this type of question is in violation of the forum rules, please forgive me and delete this thread.
