Metformin with MK-677

[Stewie]

I just did and showed you... clearly you have zero understanding here of everything put into the calculations. Aka your still not understanding or mentioning one of biggest factors of respiration rate. Read the damn article lol. It gives you plenty of examples and pharmacology for dummies basically 101.. if a mouse dose is 0.4 then human dose is 0.1 mg. You seriously need to read the paper. You actually believe the dose is 100000...

This is such basic shit man..

You're correct, I retract my original configuration. I erroneously placed 200mg as the given dose.

The actual dose of 200mg/kg per given dose would be roughly 7.14mg to extrapolate to roughly 3947.9mg. So, you're correct.

I could give a thousand excuses, yet it wouldn't validate my errors. I own that.

I'll will pass forward that you still cited an in-vitro cell culture murine model study, yet you were quick on the draw to exclude these as proof-of-concept in your previous comment.

 

[Aliendogstar]

Yeah I tried it , it didn't get along well with my Paxil (anxiety,PTSD).
75mg Benadryl and 15mg Melatonin work pretty well but leaving me feeling kinda hung over the next day. The biggest issue is that I'm so damn busy I'm lucky to get in bed by 10:30 then I'm back up at 4:30. Obviously this is was way off course especially for a 40+yr old but I stay busy as a one leg man in a cat kicking contest. So I try to get as much quality sleep as I can in the limited time time. CBD+THC worked pretty well but I'm subject to drug test so the THC is a no go.

That's 3 Advil PM's and 3x regular dose of melatonin. No wonder you're groggy. If you take it early enough can you get away with less?