milligrams per IU of GH

[gtj220]

Could someone educated me on how many milligrams of GH is in a typical chinese blue top 10 IU vile. The question was put to me so i'm curious. I know we all refer to iu's but I thought i'd ask after my search wasn't successful.
Thanks

 

[T-man]

I've heard of anywhere between 2.7-3.3 mg of GH per 10 unit vial.

 

[Bobaslaw]

Hey T,

Those numbers could be right, but it would be hard to know for sure IMO. Here's how the whole standards thing works and how you might apply it to what you are getting in your vial.

Another thread with some more info I dug up and posted (I never did respond to Dat's challenge now that I've reread it!)...

http://www.professionalmuscle.com/forums/peptides-growth-factors/49508-converting-mg-ius.html

Anyhow...

[Snooze Alert]

International Unit (IU) standards are defined by the World Health Organization (WHO) Expert Committee on Biological Standardization. They do this to maintain a common ground between preparations and do this by defining a chosen reference sample of rHGH, in this case, which to base all manufactured Pharma preparations around the world.

Currently the reference standard is 1mg=3IU*

*IU is a reference of "amount biological activity", which 1mg of standardized reference sample induces.

The previous reference standard predating the current one (from 2000) had a reference sample of 1mg=2.7IU, thus you still see this calculation thrown out there in many write-ups, etc, which lead to some unnecessary debates sometimes

The question is, do the generic manufacturers really adhere to the WHO standards and produce their HGH to the same potency/purity?

Most likely not, thus it may not be a fair comparison between equally represented vials of generic Blues vs. a USP Pharma grade. Something to keep in mind because of the way one can skew the final dose depending on how you interpret the mg/iu ratio.

Example:

so WHO says that per their ref sample 3IU of biological activity is seen with administration of a 1mg preparation. A generic non compliant manufacturer may have a preparation of 1mg that ONLY induces a 1IU degree of Bio activity**...

**not accounting for weight of additional fillers/buffers comprising the total vial weight.

That would equate a pharma preparation of 3.33mg containing enough HGH to produce 10IU of Bio Activity.

A generic less potent preparation (1mg=1IU) may say it contains enough preparation for 10IU of biological Activity, which may or may not be true depending on how it is being interpreted

A) IF the generic actually has a true 10IU potency it must weigh more, 10mg vs 3.33mg in this case since it is less potent and does not adhere to standards (possibly).

B) IF The generic only has 3.33mg, the manufacturer may incorrectly define that it MUST be 10IU based by the standards amount RATHER than the calculation that defines their sample. In this case they may unscrupulously say "3.33mg IS 10IU right"... Wrong. Your 3.33mg is in fact 3.33IU (3.33mg X 1IU).

SO how many IU's are contained in a preparation of generic HGH? WHO knows... or more appropriately with respect to the pun.. WHO doesn't

Sorry for the boring never ending read!

 

[gtj220]

very informative post, It would be great to hear from one of the sponsers on this subject.

Hey T,

Those numbers could be right, but it would be hard to know for sure IMO. Here's how the whole standards thing works and how you might apply it to what you are getting in your vial.

Another thread with some more info I dug up and posted (I never did respond to Dat's challenge now that I've reread it!)...

http://www.professionalmuscle.com/forums/peptides-growth-factors/49508-converting-mg-ius.html

Anyhow...

[Snooze Alert]
International Unit (IU) standards are defined by the World Health Organization (WHO) Expert Committee on Biological Standardization. They do this to maintain a common ground between preparations and do this by defining a chosen reference sample of rHGH, in this case, which to base all manufactured Pharma preparations around the world.

Currently the reference standard is 1mg=3IU*

*IU is a reference of "amount biological activity", which 1mg of standardized reference sample induces.

The previous reference standard predating the current one (from 2000) had a reference sample of 1mg=2.7IU, thus you still see this calculation thrown out there in many write-ups, etc, which lead to some unnecessary debates sometimes

The question is, do the generic manufacturers really adhere to the WHO standards and produce their HGH to the same potency/purity?

Most likely not, thus it may not be a fair comparison between equally represented vials of generic Blues vs. a USP Pharma grade. Something to keep in mind because of the way one can skew the final dose depending on how you interpret the mg/iu ratio.

Example:

so WHO says that per their ref sample 3IU of biological activity is seen with administration of a 1mg preparation. A generic non compliant manufacturer may have a preparation of 1mg that ONLY induces a 1IU degree of Bio activity**...

**not accounting for weight of additional fillers/buffers comprising the total vial weight.

That would equate a pharma preparation of 3.33mg containing enough HGH to produce 10IU of Bio Activity.

A generic less potent preparation (1mg=1IU) may say it contains enough preparation for 10IU of biological Activity, which may or may not be true depending on how it is being interpreted

A) IF the generic actually has a true 10IU potency it must weigh more, 10mg vs 3.33mg in this case since it is less potent and does not adhere to standards (possibly).

B) IF The generic only has 3.33mg, the manufacturer may incorrectly define that it MUST be 10IU based by the standards amount RATHER than the calculation that defines their sample. In this case they may unscrupulously say "3.33mg IS 10IU right"... Wrong. Your 3.33mg is in fact 3.33IU (3.33mg X 1IU).

SO how many IU's are contained in a preparation of generic HGH? WHO knows... or more appropriately with respect to the pun.. WHO doesn't

Sorry for the boring never ending read!

 

[T-man]

very informative post, It would be great to hear from one of the sponsers on this subject.

lol then PM them. I'll wager that Bob knows more about the subject than any peptide slingers do.

Another one for the Articles Forum Bob. lol

 

[gtj220]

lol then PM them. I'll wager that Bob knows more about the subject than any peptide slingers do.

Another one for the Articles Forum Bob. lol

I did contact one, he said gh is never measured in milligrams, only iu's. But some of the reasearch on the net refers to getting a certain amount of milligrams per kg of bodyweight. Thats why I got curious when the question was put to me, just like to learn a little something.

 

[T-man]

Never measured in milligrams? lol Anyone with a thousand bucks and a Tradekey account can sell GH these days.

In spite of Bob's informative but lengthy post you can figure approximately 3 milligrams per 10 unit vial. At least thats what I found when I cracked open a blue top vial once and weighed it. It seems like a sources are going to 4 unit and even 2 units per vial, why is beyond me, so make sure your supplier is up front about how many units his vials have.

 

[gtj220]

Never measured in milligrams? lol Anyone with a thousand bucks and a Tradekey account can sell GH these days.

In spite of Bob's informative but lengthy post you can figure approximately 3 milligrams per 10 unit vial. At least thats what I found when I cracked open a blue top vial once and weighed it. It seems like a sources are going to 4 unit and even 2 units per vial, why is beyond me, so make sure your supplier is up front about how many units his vials have.

your help is appreciated, well if there are 3mg per 10 iu vile what do you consider an effective dose. Is 4-6 iu's going to get the job done at that dose? I've been at 5 iu's just to keep it simple. (by the way, info I got was from a popular sponsor on this board)

Thanks Again T

 

[T-man]

You are welcome. Glad to help as is my friend Bob I'm sure.

5 units a day is a fine dose. I've ran everything from 2 units a day to 20 units EOD and got good benefits from all of it. Anyone telling you that GH has to be run a certain way at a certain dose is full of shit. Except for Dat of course when he laid out a beautiful protocol involving peptides and low dose recombinant GH which is going to be my lab rat's next experiment.

The thing about GH is to run it long-term. 2 units a day for 6 months is more beneficial than 5 units a day for 2 months if thats all you can afford.

 

[gtj220]

You are welcome. Glad to help as is my friend Bob I'm sure.

5 units a day is a fine dose. I've ran everything from 2 units a day to 20 units EOD and got good benefits from all of it. Anyone telling you that GH has to be run a certain way at a certain dose is full of shit. Except for Dat of course when he laid out a beautiful protocol involving peptides and low dose recombinant GH which is going to be my lab rat's next experiment.

The thing about GH is to run it long-term. 2 units a day for 6 months is more beneficial than 5 units a day for 2 months if thats all you can afford.

common sense, that's what I like to hear. FYI a TOP pro was in my town at a grand opening of a supplement shop ( an Arnold Classic champ) and relayed he took 6 iu's before bed in the upper thigh. Upper thigh because its so vascular, and before bed because it was the bodys best time for uptake naturally.

 

[T-man]

Sure. Before bed is fine. Upon waking is fine. While eating lunch is fine. lol you get the point. Everyone has their "magic GH hour", but in reality administering rHGH has been likened to bumping a balloon up into the air... its gonna float for while just as the effects of the GH will continue throughout the day no matter when you shoot it, even though the "half life" (sorry Dat... lol) is only a few hours long.

I've heard of guys shooting GH IM but I was never a big fan of it, not preferring to waste scar tissue on such a small shot, so its always been sub-q for me as again its in your body for quite a while and does its job no matter how you get it in there.