I was scared shi*less my first time. I'll admit I have a hatred for needles. I actually soak a washrag in steaming hot water, wrap the syringe (with cap on) in the wash rag while I am in the shower. I found it's much easier after a hot shower. I was able to tell a difference the 2 times I did not do the rag trick, it's much easier to inject when it's warm. I guess the shower helps relax the muscle or something, not sure I just know it's easier. I also make sure I get a drop or two on the actual needle when I get the air bubbles out, this seems to make it easier to push the needle in. Always aspirate!! I am also very paranoid about infections, so i wipe the area with 2 or 3 alcohol wipes first. I also wipe down the counters with bleach wipes and use hand sanitizer before I even get my supplies out. On my second cycle, twice a week injections and no problems yet. I will admit to being paranoid, but I would rather take some extra time and make my chances of infection as minimal as possible. All of this could just be me convincing myself it won't hurt, but it's seemed to work so far.