I obviously avoid any type of medication while on cycle unless it's absolutely necessary. Due to some dental issues that have been extremely painful, I've been able to work out through the pain, only taking a pain killer at night. For the last few nights, though, I'd take a hydrocodone to help manage the pain so I could sleep, but they are completely ineffective. Off cycle they've always worked (never taken recreationally). Is there something going on biologically on cycle that causes these medications to be less effective?