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http://www.professionalmuscle.com/forums/showthread.php?t=44755
After reading the thread recently regarding DNP I came accross this study,
www.jbc.org/cgi/reprint/220/2/553.pdf EFFECT OF PROGESTERONE ON OXIDATIVE PHOSPHORYLATION, I've read it through a few times and am trying to grasp a few things I was hoping someone knowledgable on this would be able to explain.
Im aware that oxidative phosphorylation is the reason behind dnps fat loss because of how it inhibits this process, DNP binds to protons on one side of a membrane in mitochondria, and being fat-soluble it drifts to the opposite side where it loses the protons. After reading this study am I to understand that progesterone does the same?
I was always under the assumption that excessive progesterone was a bad thing?
the other thing that in my head Ive somehow managed to relate is the drug ru-486 (mifepristone) this will eliminate progesterone at relatively small doses, and supposedly cortisol in the higher ranges 600mg a day I think I read in some studies, used in the treatment of cushings, is it possible that the reason effects are not massively noticed on this drug when cortisol is eliminated due to the lack of progesterone in the system effectively doing the role of DNP albeit in a small way?
After reading the thread recently regarding DNP I came accross this study,
www.jbc.org/cgi/reprint/220/2/553.pdf EFFECT OF PROGESTERONE ON OXIDATIVE PHOSPHORYLATION, I've read it through a few times and am trying to grasp a few things I was hoping someone knowledgable on this would be able to explain.
Im aware that oxidative phosphorylation is the reason behind dnps fat loss because of how it inhibits this process, DNP binds to protons on one side of a membrane in mitochondria, and being fat-soluble it drifts to the opposite side where it loses the protons. After reading this study am I to understand that progesterone does the same?
I was always under the assumption that excessive progesterone was a bad thing?
the other thing that in my head Ive somehow managed to relate is the drug ru-486 (mifepristone) this will eliminate progesterone at relatively small doses, and supposedly cortisol in the higher ranges 600mg a day I think I read in some studies, used in the treatment of cushings, is it possible that the reason effects are not massively noticed on this drug when cortisol is eliminated due to the lack of progesterone in the system effectively doing the role of DNP albeit in a small way?
