There are a minority who will recommend taking their orals all in one dose, but I've never really seen the logic in it. There's no reason NOT to split them up and plenty of reasons to do so, so I always split my orals up into more or less evenly spaced doses. IronMike
I would split them up through out the day too, now if you dont have the luxury of doing this for whatever reason, make sure to take them about 2-3 hrs befor workout.