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Research shows Trenbolone has powerful progestin binding activity

Black Beard

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This helps explains some of the mood/libido effects as well as the gynecomastia.



Here's a link to the study and a screenshot of the chart:


RsqnlUT.png



https://academic.oup.com/jcem/article/89/5/2498/2844817


Nandrolone's progestin activity is not listed, but it is the parent hormone for many of the progesterone's used in medicine, including many forms of hormonal birth control.

Anecdotally, i only get gyno from trenbolone and nandrolone, never from E2 no matter how high it gets. I've successfully completely reversed the gyno +6 times with raloxifene at 60 mg ran for 6-12 weeks each time.
 
I also get gyno on tren. Never fails and nothing stops it. Ive tried nolvadex, crashing e2, prami, caber, nothing works except stopping tren but everytime I've stopped tren, within a couple months, gyno will be gone. I'm talking, swollen, hard glands, puffy, and very painful but tren always keeps me coming back, lol.

I've had e2 over 100 and no gyno symptoms. Only tren.

Sent from my SM-G965U using Tapatalk
 
[lang=ro]Same here I crushed my e2 to below 5 and still had gyno issues on tren. When i stopped the tren gyno resolved very fast. Strangely I had no issues with nandrolone[/lang]
 
I also get gyno on tren. Never fails and nothing stops it. Ive tried nolvadex, crashing e2, prami, caber, nothing works except stopping tren but everytime I've stopped tren, within a couple months, gyno will be gone. I'm talking, swollen, hard glands, puffy, and very painful but tren always keeps me coming back, lol.

I've had e2 over 100 and no gyno symptoms. Only tren.

Sent from my SM-G965U using Tapatalk

Yep, same here. High E2 will never give me gyno, but even 150 mg of tren ace will do it.

I've even tried tren solo just to experiment. Libido, mood and erections were excellent on 200 mg tren ace only, but the gyno comes out eventually.

Like you said, i've always been able to reverse it though thank god.

[lang=ro]Same here I crushed my e2 to below 5 and still had gyno issues on tren. When i stopped the tren gyno resolved very fast. Strangely I had no issues with nandrolone[/lang]

I got bad gyno from NPP the one time i ran. I'm really gyno sensitive to 19-nors but high E2 is fine for me.
 
Last edited:
tren can cause gyno with elivated igf too:lightbulb:

was discussing generalized effects of various aas and body types in another thread.

would be interesting to get a lil more feedback on that.
roughly seems that guys who are naturally on the skinny or wirey side tend to get a great reaction from tren, while those who get fat easier or endo/meso get more sides.
 
That whole family of compounds the Nors will do that.
Ment is very much the same, you see guys taking a higher dosage, then drowning the E's with all Ai's and SERMS and many times a combination of...
annihilating any existence of circulating E.
Yet the gyno etc... keep progressing.
So the careful use of these compounds is recommended. Do they have an application in our arsenal YES!
Is there a pill that will cover and correct all our AMBITIOUS decisions?? NO!!!
 
Good post, but this information has been around for years.


Trenbolone shows a full agonist response to the progesterone receptor in human bioassays.
 

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