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- Joined
- Jun 5, 2006
- Messages
- 7
Has Anyone took Synthetine Interveneously.Article below gives a brief way way of how l-carnitine works.
"Q: What is this L-Carnitine stuff I've been hearing about?
A: It's L-carnitine and I'm guessing you've heard that if you inject it subcutaneously, it'll result in localized fat loss. Well, first let me just say that the ampoules people are getting are meant for intravenous use and not subQ or intramuscular injection. The reason it's intended for IV use is because it's oral bioavailability is very low (15-16%), whereas IV bioavailability is of course 100%.
Now, just as a simple physiology review, L-carnitine essentially acts as a carrier of fatty acids and transports them in to the mitochondria so that they can then be oxidized. So, yes, carnitine plays an essential role in fat oxidation. However, the idea of injecting it in to adipose tissue (subQ administration) is ridiculous. The obvious reason being that adipocytes have no mitochondria!
This is yet another case where people need to realize that systemic absorption is necessary for an effect and that they should forget about "localized" effects. I'll admit that there are a few (very few) drugs where localized injections may be of benefit but for the most part they're a waste.
Last but not least is the fact that supplementing with carnitine isn't necessary unless you're on a severely calorie deficient diet and in that case, stick to supplementing with it orally… unless you happen to like intravenous injections.(21)"
"Q: What is this L-Carnitine stuff I've been hearing about?
A: It's L-carnitine and I'm guessing you've heard that if you inject it subcutaneously, it'll result in localized fat loss. Well, first let me just say that the ampoules people are getting are meant for intravenous use and not subQ or intramuscular injection. The reason it's intended for IV use is because it's oral bioavailability is very low (15-16%), whereas IV bioavailability is of course 100%.
Now, just as a simple physiology review, L-carnitine essentially acts as a carrier of fatty acids and transports them in to the mitochondria so that they can then be oxidized. So, yes, carnitine plays an essential role in fat oxidation. However, the idea of injecting it in to adipose tissue (subQ administration) is ridiculous. The obvious reason being that adipocytes have no mitochondria!
This is yet another case where people need to realize that systemic absorption is necessary for an effect and that they should forget about "localized" effects. I'll admit that there are a few (very few) drugs where localized injections may be of benefit but for the most part they're a waste.
Last but not least is the fact that supplementing with carnitine isn't necessary unless you're on a severely calorie deficient diet and in that case, stick to supplementing with it orally… unless you happen to like intravenous injections.(21)"
