Tricyclic Antidepressants and Their Effects on GH secretion

[BioBuild]

Been reading some interesting data lately about tricyclic antidepressants (TCA) and their effects on GH secretion. I personally have been taking Clomipramine (CI) for several years for OCD and overactive bladder (it has anticholinergic properties which help reduce my bladder spasms).

A particularly interesting study: https://sci-hub.ac/https://link.springer.com/article/10.1007/BF00426382?LI=true

Regarding GH stimulation due to antidepressants, at this stage of research, one may say that NE uptake inhibitors, such as DMI and nomifensine specifically (Laakmann et al.
1979), are, indeed, reliable stimulators of GH secretion.

Antidepressants with small inhibitory action on NE uptake, but strong 5-HT uptake inhibition, such as CI
and amitriptyline, do not always induce a stimulation of GH secretion (Schulz et al. 1982). PRL stimulation, however, is rather related to the 5-HT uptake-inhibiting potency of a substance. At this point, again, it has to be emphasized that such findings are strongly influenced by dosage and mode of
administration.

I'm a bit confused though, as some research suggests that anticholinergics blunt GH release.

https://books.google.nl/books?id=F5...#v=onepage&q=anticholinergic and GHRP&f=false

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1608578/?page=2


I'm wondering if taking clomipramine is going to reduce the effectiveness of peptides? All the data I've come across on clomipramine (and other TCAs) seems to suggest, if anything, they tend to stimulate GH secretion through 5-HT and Norepinephrine pathways. Maybe the anticholinergic properties are weak enough with TCAs that they don't significantly alter GH release?

 

[BioBuild]

Well I seem to be getting all the typical sides after administering the peps so I assume they are working