i do 100iu daily. it does increase my e2 but its a trade off i am willing to take for fertility. i am in my 30s though.
i think daily is best to mimic the natural peaks and troughs that your body would make if you were natural. i cant bring myself to do test daily, currently do that E3D.
HCG can increase beta-endorphin production by as much as 10-12x. This is why many experience an increased sense of well being after using HCG.
I definitely notice a better feeling in the days following HCG administration. Its noticeable.
There is a leydig cell refractory period of at least 48 hours after administering HCG, so daily dosing isn't optimal.
200 EOD better?
I guess this refractory period is in rats though? Can't see any studies on humans. I just follow my doc's advice.
There is a leydig cell refractory period of at least 48 hours after administering HCG, so daily dosing isn't optimal.
Resensitization of Testosterone Production in Men after Human Chorionic Gonadotropin-Induced Desensitization*
Abstract. In rats, monkeys, and man, 24−h exposure to hCG can lead to a loss of testicular LH receptors and/or a decrease in the ability of the testis to pacademic.oup.com
"In man, this desensitization is reflected by a plateau in serum testosterone (after a small early rise) for 4−24 h after hCG administration despite high serum hCG and rising serum 17−hydroxyprogesterone. After 72−h exposure to hCG, serum testosterone in men doubles, suggesting that the testis has regained sensitivity to gonadotropin (resensitization) with regard to testosterone production."
Did I miss the dose in the abstract? Seems like that matters. I've read previously that 1000iu of hCG has a 96 hr refractory.
Dont have access to full paper unfortunately.
My point was that refraction is also seen in humans after dosing of HCG.
This refractory period may be reduced with the usage of an anti-estrogen like Tamoxifen (and perhaps Clomid). Its postulated estrogen is the culprit here as its directly inhibitive to leydig cells producing endogenous testosterone. Tamoxifen abolishes the block between 17- hydroxyprogesterone and testosterone allowing testosterone synthesis to continue. This can be seen in this study: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2605.1981.tb00745.x
The HCG dose is important as refraction is seen in large initial acute doses. I'm not sure its seen in smaller doses under 1000ius. I will see what I can find.