If your question is: Will running a cycle at a higher dose (say test e at 750 mgs per week for 10 weeks as opposed to test e 400 mg/wk for 10 weeks) for the first and second cycle hinder gains in future cycles?
with proper PCT and tme off between cycles, no.
What it wil do is increase unwanted sides (gyno, ance, bloat, ect) and produce no benefit in terms of gains or your abilty to keep them.
More is not neccessarily better.
If thats not your question then please re word it, the way it's asked is confusing...