2bvajra; said:
Dat I'm interested to find that hexarelin is so much more effective than GHRP-6 and intent to try it out.
First of all I would never use the phrase "so much more effective". I've discussed the relative effaciousness of GHRP-6, GHRP-2 & Hexarelin as well as other things such as prolactin & desensitization.
What I probably never discussed is "free growth hormone" or the amount of growth hormone that is unbound by a binding protein.
Perhaps 45% of GH is bound to growth hormone binding protein in circulation. What isn't widely known is that the extracellular domain of the prolactin receptor circulates in serum and has a higher affinity (attraction) for growth hormone then even its own native ligan, prolactin.
*
In a study by King & Clevenger they found that 50% of growth hormone present in the serum of a single donor was bound by serum prolactin binding protein. -
Identification and characterization of the prolactin-binding protein in human serum and milk, Kline, J.B. and Clevenger, C.V., J. Biol Chem 2001 276, 24760-24766
Also studies that measure GH in plasma (i.e. GH release) fail to distiguish between bound and free GH so I know Hexarelin is more effacious at releasing GH but keep in mind prolactin as well. Higher prolactin levels will result in higher amounts of circulating prolactin binding protein which will bind to GH which reduces GH's immediate effect and leave prolactin free which enhances prolactins immediate undesired effect.
If 45% of GH is bound to growth hormone binding protein and 50% is bound to a prolacting binding protein then ONLY 5% is free. Small changes in the amount bound to prolactin binding protein can make a significant impact.
See: A serum prolactin binding protein: implications for growth hormone, Dannies, P.S., TRENDS in Endocrinology & Metabolism, Vol. 12 No. 10 Dec. 2001
* - prolactin binding protein has an affinity for GH 100 times that of prolactin and 10 times that of GH for its own growth hormone receptor.
2bvajra; said:
You have also been discussing the advantages of adding insulin to the protocol and I was wondering if there are more or less standard guidelines for safe
dosages, since too much can complicate your life.
I'm not going to write an insulin safety guide or insulin 101. Insulin will drop your blood sugar rapidly. Getting shakey, hot profuse sweat and loss of some clarity of thought are the last warning signs before possibly losing consciousness. If you do use insulin it is necessary to use a blood glucose monior to monitor your blood sugar at each dosing level used. It is necessary to carry a couple of sleeves of glucose tablets in your pocket at all times.
2bvajra; said:
Also I'm not sure about whether I can pin all three in the same syringe. Since unlike you I don't like being a pin cushion.
You don't want to get any of the peptides mixed up in the vial. You want the insulin vial to remain all insulin & you don't want even a bit of insulin in the CJC/GHRP-6 vials.
You pin the CJC/GHRP-6 first so that GH can be created. Once that happens you can go eat, but before eating you can pin insulin. That is the general timing and it differs from administartion of synthetic GH because CJC/GHRP needs to create GH which will take 15 minutes or so. Pinning insulin at that time will mean both GH & Insulin are active concurrently.
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