These are just a few that I have bookmarked. As someone who has been 'artificially elevating' my IGF1 levels for many years I pulled my head out my ass and accepted the risks rather than live in denial. We are not just taking HGH at therapeutic doses that put our IGF1 levels in the 'slightly elevated range'. The doses of HGH and GH peptides that we generally use put us in a range far beyond what is already accepted to put one at a higher risk of getting cancer. Sure, HGH use has plenty of benefits. I'm just more conservative with my use of peptides now.
LINKS:
The IGF1 receptor signalling system and targeted tyrosine kinase inhibition in cancer
"Studies show a correlation between circulating IGF1 levels and cancer risk in some malignancies (premenopausal breast, prostate and colorectal carcinomas, as well as lung, endometrial and bladder cancers).28 Individuals with high serum IGF1 concentrations and/or lower levels of IGFBPs had more than twice the risk of developing cancer than those at the low end of the normal range."
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"Conclusions: Higher serum IGF-I in older men is associated with increased risk of cancer death, independent of age, adiposity, lifestyle, and cancer history. These results suggest caution in the use of IGF-I-enhancing therapies to slow the adverse effects of aging."
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Findings: We identified 21 eligible studies (26 datasets), which included 3609 cases and 7137 controls. High concentrations of IGF-I were associated with an increased risk of prostate cancer (odds ratio comparing 75th with 25th percentile 1·49) and premenopausal breast cancer (1·65) and high concentrations of IGFBP-3 were associated with increased risk of pre-menopausal breast cancer (1·51).
Growth hormone, the insulin-like growth factor axis, insulin and cancer risk
"The evidence that GH, IGF-I and insulin can promote and contribute to cancer progression comes from various sources, including transgenic and knockout mouse models and animal and human cell lines derived from cancers. Assessments of the GH–IGF axis in healthy individuals followed up to assess cancer incidence provide direct evidence of this risk."
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Mice with an inactivated IGF1 receptor gene lived on average 26% longer than normal mice.
Growth hormone protects colorectal cancer cells from radiation
"The results suggest that rhGH is able to protect colorectal cancer cells from radiation through the interaction with the growth hormone receptor, which is associated with the promotion of DNA damage repair activity."