The process of hair growth has three cycles: Anagen which is the growth phase followed by catagen, a transitional phase and the resting phase, telogen. Throughout this process, Fibroblast Growth Factors (FGF) and microRNAs play key roles as signaling pathways. FGF helps grow healthy hair or initiate a new growth phase during telogen by signaling the growth stimulatory compounds to induce a new hair growth phase.
Researchers in the Perelman School of Medicine at the University of Pennsylvania have determined the role of a key growth factor, found in skin cells of limited quantities in humans, that helps hair follicles form and regenerate during the wound healing process. This growth factor, Fgf9, is initially secreted from gamma delta T cells, an unconventional, rare subset of T cells involved in the immune response. Once released, Fgf9 serves as the catalyst for a signal sent via the dermal Wnt pathway. The signal prompts further expression of Fgf9 in structural cells called fibroblasts, and adds to the generation of new hair follicles. Researchers believe that this growth factor could be used therapeutically for people with various hair and scalp disorders. The study appears in an advance online publication of Nature Medicine. Credit: George Cotsarelis and Elsa Treffeisen/Penn Medicine.
Fibroblast growth factors, or FGFs, are a family of growth factors, with members involved in angiogenesis, wound healing, embryonic development and various endocrine signaling pathways. The FGFs are heparin-binding proteins and interactions with cell-surface-associated heparan sulfateproteoglycans have been shown to be essential for FGF signal transduction. FGFs are key players in the processes of proliferation and differentiation of wide variety of cells and tissues.
In humans, 22 members of the FGF family have been identified, all of which are structurallyrelated signaling molecules:[1][2][3]
She needs a topical conditioner with FGF. I have it.
Are you in the USA?