What's the point of a stand alone GDA if you're taking dirt cheap generic metformin anyway? We already know metformin doesn't lower IGF meaningfully when using exo GH. Further, it's better than berberine.
I don't really think we can say met is "better" than berberine, as the word "better" is subjective. Clinical research has shown that berberine is just as effective as Met. I vastly prefer berberine over Met, as I think it is safer (potential drug interactions aside) and has more overall benefits. In my opinion, when a natural alternative does the job just as well as a synthetic drug, I always recommend going the natural route. We already know met has negative side effects...and can potentially even KILL someone, while berberine won't do any of that. Berberine also has a number of beneficial effects Met doesn't have. Plus, Met makes me nauseous (as it does to a LOT of other people) and causes significant gastrointestinal upset in a lot of people. Berberine is WAY less likely to cause that. Lastly, according to the research I've read, met is even more likely to interferes with muscle growth than berberine, although I think their negative effects on growth are largely over-exaggerated.
Regarding your comment that there is no need to use a "GDA" if one is already using met, I completely disagree. First of all, GDA aren't really a class of supplement. Rather, the term "GDA" represents a singular function applicable to multiple different classes of supplements within this general category, which includes insulin sensitizers, insulin mimetics, and insulin secretagogues. All of those classes of compounds have "GDA" effects, but can vary significantly in their overall effect profile. Their are MANY benefits associated with these classes that Met does not provide. For example, the primary effect of insulin secretagogues is to actually cause the pancreas to release additional insulin into the bloodstream. With the right combination of compounds at the proper doses, this insulin releasing effect can be quite profound. Met doesn't do that at all. This is just one of MANY examples.
Yes, I am going to be selling an insulin secretagogue (that also has insulin sensitizing and insulin mimetic effects), so you can say the following comment is biased, but I am telling the truth when I say that, as someone interested in getting stringer and bigger, I would MUCH rather use my product than Met.
It just seems like overkill to pay for a stand alone product if using metformin and already watching your carbs, imo.
I take an ALA/ALCAR combo cap before meals, but not so much for ALA's GDA properties, as moreso for the great synergy and effects of ALCAR and ALA together at the mitochondrial level. A hallmark of aging is decreased mitochondrial function while at the same time ROS production becomes increased. ALCAR increases mitochondrial capacity and ALA decreases ROS, so they complement each other to provide a rejuvenating effect on the mitochondria.
Further, metformin is better for anti aging than any fucking GDA out there. It's a virtual wonder drug with zero sides in most normal people.
Not so sure about that. We already know what Met does and how it does it. With the right combination of natural products we can duplicate that effect, while also providing a potentially far greater number of overall health benefits than Met could ever provide...all without any of the negative side effects Met has on health. And it does have negative health effects--they just usually aren't profound enough in most people to cause serious health issues.
I think people give Met way too much credit...and Big Pharma just loves it.