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A Solution to Tren- Understanding Histamine and how to regulate it

bbxtreme

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I posted about this briefly in my AMA thread, but I figured it was only fair to share with everyone.

For years we have been plagued with what many believed to be the non-negotiable side effects of using Tren.

The reality is that many of the side effects that individuals experience from Tren are simply the result of irritated mast cells within our body.

This happens as a response to the increased androgen levels from Tren. Once mast cells become irritated they release excess histamine into the body that is not able to be metabolized.

This excess of histamine leads to the issues that many experience from Tren.

Instead of writing a long post here I have attached an article that I have written (with citations) that discusses the role of histamine in the body for those interested.

Sometimes I forget that the things I do in real life also apply to bodybuilding as well.

Enjoy and happy Tren season!
 

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  • Understanding Histamine and How to Regulate it.pdf
    58.2 KB · Views: 188
I see diphenhydramine is not mentioned in the PDF. Given that it's the most widely used anti-histamine why doesn't it work here?
 
I see diphenhydramine is not mentioned in the PDF. Given that it's the most widely used anti-histamine why doesn't it work here?
This is one of many articles I have written for my brand. Given our focus is “natural solutions” I typically aim to only discuss natural solutions in our articles.

For someone looking to mitigate the side effects of tren one could use an OTC anti-histamine with DAO to achieve a similar if not the same result.

The goal is to metabolize the excess histamine (DAO does this) while managing the mast cells so balance is restored which will alleviate the side effects.

Maybe one day I’ll have enough time to write articles fully dedicated to bodybuilding. Lol
 
This is one of many articles I have written for my brand. Given our focus is “natural solutions” I typically aim to only discuss natural solutions in our articles.

For someone looking to mitigate the side effects of tren one could use an OTC anti-histamine with DAO to achieve a similar if not the same result.

The goal is to metabolize the excess histamine while managing the mast cells so balance is restored which will alleviate the side effects.

Maybe one day I’ll have enough time to write articles fully dedicated to bodybuilding. Lol
What non negotiable sides are we talking about
 
Heart burn, GERD, insomnia, digestive issues, brain fog, respiratory issues, etc.
I suffer 3 of 5 of the above when using Tren A or E.
HB, GERD and digestive issues.

Hopefully I'd see some sensation when I Micro dose Tren A in July.

Thank you!
 
I suffer 3 of 5 of the above when using Tren A or E.
HB, GERD and digestive issues.

Hopefully I'd see some sensation when I Micro dose Tren A in July.

Thank you!
Add DAO and the items in the article- stinging nettle, holy basil and Quercetin (or an anti-histamine) and you should eliminate most of that.

Apologies I couldn’t post the article here as I wanted to show the citations and they wouldn’t hyperlink here, hence the PDF.
 
So… for us who arnt about the science, Benadryl?
Benadryl and DAO enzyme would do the trick.

The Benadryl won’t metabolize the excess histamine- it’s a two part solution.

1. Stop pissing off the mast cells
2. Metabolize the excess histamine
 
One other pathway for the GERD - everyone here who's started taking Dr. Ohhira's probiotics has reported almost no heartburn from tren or other compounds. I never get it any more with 1 cap of the Professional formula every night.
 
I remember about 10 years ago, someone on Anasci recommend using Nasacort when running tren. Any thoughts on this?
It’s a corticosteroid so it may alleviate some of the respiratory issues from tren, but personally think it’s a weak option compared to using Benadryl or Zyrtec with DAO.
 
One other pathway for the GERD - everyone here who's started taking Dr. Ohhira's probiotics has reported almost no heartburn from tren or other compounds. I never get it any more with 1 cap of the Professional formula every night.
💯 I take this blend everyday. Hands down the best probiotic IMO.

Histamine is only one piece of the equation still. It’s just a large one that has been overlooked in mitigating the side effects. Hell even I overlooked it.

Most of the time when we think of histamine intolerances it’s food related or women dealing with hormonal fluctuations, thus what led me down the path to connecting the dots. Their hormonal fluctuations (increased androgens) trigger this same reaction.
 
Thank you for the information. Are you familiar with the seeking health products and if so any thoughts on them

I am familiar with them. They’re a good brand and were the first on the scene for the histamine issues.

They are over charging by splitting up the products, but their DAO (histamine digest) is a good one and is cheaper than many others out there. You want to aim for about 4mg per day.
 
I am familiar with them. They’re a good brand and were the first on the scene for the histamine issues.

They are over charging by splitting up the products, but their DAO (histamine digest) is a good one and is cheaper than many others out there. You want to aim for about 4mg per day.
Appreciate the info. Any chance histamine issues could be causing sinus and upper respiratory infections. I’ve been sick multiple times this year and have no clue why. Doctor didn’t have any input just prescribes Methylprednisolone and Azithromycin and sends me on my way
 
Appreciate the info. Any chance histamine issues could be causing sinus and upper respiratory infections. I’ve been sick multiple times this year and have no clue why. Doctor didn’t have any input just prescribes Methylprednisolone and Azithromycin and sends me on my way
If unchecked for long enough it is possible as with excess histamine and irritated mast cells your body and respiratory will be in an inflamed state.

Overall I’d check deeper into your blood work and immune markers though on that one personally. There’s still a root cause under histamine issues- in this case it’s Tren or increased androgens. In other cases it’s eating food high in histamines.
 
Great read! I still love tren and I'd love to use it again.

What I hate (and love) is that I get zero sides from Tren (ok...to be fair haven't taken it since 2018). But I was on it off and on for years at a lower dose of 100-150mgs a week and I sleep fine, feel fine, etc. I am just so damn paranoid about kidney damage from it from mechanisms unrelated to BP as my BP is under control.
 

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