Can anyone explain these studies to me

[Johan]

I just did some searches on pubmed about ulcers to se if I can find something interesting on how to prevent or cure them.

Found these 3 studies. 2 of them is with whey protein concentrate and the third omega 3.

Since I dont understand anything they have written I dont know realy what it means? Would fishoil and whey protein concentrate protect against ulcers in general or just the ones caused by ethanol and indomethacin. Is whey protein concentrate roughly the same as the whey protein powder we bodybuilders use?

J Med Food. 2004 Fall;7(3):309-14. Related Articles, Links


Protective effect of bovine milk whey protein concentrate on the ulcerative lesions caused by subcutaneous administration of indomethacin.

Rosaneli CF, Bighetti AE, Antonio MA, Carvalho JE, Sgarbieri VC.

Departamento de Alimentos e Nutricao, Faculdade de Engenharia de Alimentos, Universidade Estadual de Campinas, Campinas, Sao Paulo, Brasil.

The protective effect of a whey protein concentrate (WPC) was studied in three models of stomach ulcerative lesions induction: subcutaneous injection of indomethacin, and stress induced by either intraperitoneal injection of reserpine, or immobilization and holding in the cold (4 degrees C, 2 hours). Adult Wistar rats (300-400 g) were used for acute (single-dose), repetitive, or subchronic (10 days) administration of WPC prior to treatment with the ulcerogenic factors. The best protection was achieved in the indomethacin model for repetitive and subchronic experiments, reaching 50.1% and 44%, respectively, inhibition of the ulcerative lesions, which was significant at 1% probability (P <.01). For the immobilization and cold model, maximum inhibition by WPC was 22.1%, and that for the reserpine model was 23.8%. In both models the inhibition was not significant (P >.05) compared with saline (negative control).

PMID: 15383224 [PubMed - indexed for MEDLINE]

J Med Food. 2002 Winter;5(4):221-8. Related Articles, Links


Efficacy of a whey protein concentrate on the inhibition of stomach ulcerative lesions caused by ethanol ingestion.

Rosaneli CF, Bighetti AE, Antonio MA, Carvalho JE, Sgarbieri VC.

Instituto de Tecnologia de Alimentos, Av. Brasil, 2880-CEP 13081-001, Campinas, SP-Brasil.

The purpose of this research was to test the ability of a whey protein concentrate (WPC) to inhibit gastric mucosal ulcerative lesions caused by oral administration to rats of absolute ethanol. Acute administration (single doses) of WPC resulted in 41% inhibition of the ulcerative lesion index (ULI), and 73% inhibition was obtained with repetitive doses. In a 10-days subchronic treatment study, the inhibition was 64%, all relative to a saline treatment (negative control). Alkylation of sulfhydryl compounds by subcutaneous injection of N-ethylmaleimide essentially eliminated the WPC protection. Treating the rats with an intraperitoneal injection of butathionine sulfoximine, which inhibits glutathione synthesis, reduced WPC protection to 35% and 52% for single and double doses, respectively. Taken as a whole, the results indicate that WPC does protect gastric mucosa from ethanol damage and that the protection depends on sulfhydryl compounds present in the WPC, including its capacity to stimulate glutathione synthesis.

PMID: 12639397 [PubMed - indexed for MEDLINE]

Food Chem Toxicol. 1995 Jul;33(7):553-8. Related Articles, Links


Effect of acute administration of fish oil (omega-3 marine triglyceride) on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats.

al-Harbi MM, Islam MW, al-Shabanah OA, al-Gharably NM.

Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

The fish oil commercially known as Marine-25 (omega-3 marine triglyceride) is an eicosapentaenoic acid (EPA)-rich oil. It was investigated for its ability to inhibit gastric secretion and to protect the gastric mucosa against the injuries caused by pyloric ligation, non-steroidal anti-inflammatory drugs (NSAIDs--aspirin and indomethacin), reserpine, hypothermic restraint stress and necrotizing agents [0.6 M HCl 0.2 M NaOH or 80% (v/v) aqueous ethanol]. The results showed that the fish oil, at a dose of 5 or 10 ml/kg body weight, provided significant protection in the various experimental models used. It produced a significant inhibition of gastric mucosal damage induced by pyloric ligation, NSAIDs, reserpine or hypothermic restraint ulcers. Fish oil also exerted a significant inhibitory action on gastric mucosal lesions produced by various necrotizing agents. Our findings show that fish oil rich in eicosapentaenoic acid possesses both antisecretory and antiulcerogenic effects.

PMID: 7628790 [PubMed - indexed for MEDLINE]

 

[Tzzz]

they suck

Indomethacine is an NSAID and NSAID's (like aspirin) cause ulcers. Seems like whey protein and fishoil may help prevent it. But if u have one, u should take proton pump inhibitors (and antibiotics if u have helicobacter pylori). That's all i know .