Are you talking about coming completely off everything in order to clean your receptors out? Or what?
Not totally off, the problem is not receptors, is the sensivety to androgens, you need to restore the balance of the hypothalamus-pituitary-adrenal axis.
To much blood concentration of steroid hormones for longer period of time will prevent your HPAX to function normal.
Diet and training, training is the one that up-regulate the receptors.
So on ur trt cruz u don't run anything like bronkid,phentermine,dnp ,t3 or etc. To help speed up this process other than time in time off. I'd like to do 2 20 week cycles a year if thats even possible without wasting gear .
short answer is no as little slice said. and as emeric said - diet and training.
also estradiol is a greater issue than cleaning your receptors as it competes and docks with testosrerone receptors. when your receptors are activated by a hormone the receptor is drawn into the cell and then suitable effects take place. testosterone is fat soluble. new receptors on the cell wall will not work the way they should if you are ingesting too many unhealthy fats and not a sufficient amount of EFAs like fish oil etc... high in omega-6 and omega-3 PUFAs. take care of your cells through clean diet.
"Four important fat-soluble vitamins are A, D, E, and K. Vitamins A, D, and K cooperate synergistically, not only with each other but also with essential minerals like magnesium. To boost absorption of these vitamins, eat your veggies with some olive oil or raw organic butter. Coconut oil is another excellent choice, and has been found to improve absorption of antioxidants and other nutrients better than other fats"
Four Important Fat-Soluble Vitamins