People always seem to forget tren inhibits thyroid output, one of the reasons it is good at sparing muscle mass while in a caloric deficit.
While high doses of T3 on a cutting diet will eat muscle really fast, a healthy thyroid output while calories are maintenance, insulin is normal and androgens are upper range, is actually an anabolic environment.
In other words, taking way too much tren, especially over time, will kill gains and energy due to reduced thyroid output. I'm not sure taking t3 will magically fix it, but I do know that there is a time for a tren and there is a time for no tren.
I also have a really good feeling there is a bell-curve when it comes to overall androgen use. Too low and you're not going to get any benefit, too high and you offset the benefits with side effects that limit gains. For instance, we don't know if myostatin increases in response to huge doses. Remember, the body is smarter than our minds are.
I'm willing to bet things like myostatin begin to work really hard against us when we're piling on androgens above a certain threshold AND for a longer than healthy amount of time. I mention Tren having an effect on T3 output, but I'm sure the others also have an effect.
Also, Anavar obliterates Cortisol. Out of control, prolonged levels of Cortisol will be murderous to the body. BUT, sustained inhibition of Cortisol will lead to loss of energy, reduced subcutaneous fat loss, HYPOGLYCEMIA (which explains the ravenous, unhealthy eating that comes from too much androgens IMO) and in some sense it is actually important in the process of anabolism. Hell, the reason why dianabol is such a powerful drug is that it actually increases Cortisol.
So if you're going to blast, don't do 3 grams, and keep it short.
More than what is needed is not better, it is detrimental.
And I haven't even gotten into the health issues associated with those dosages. Your beautiful Heart Muscle is being fucked when you do these dosages. That gorgeous piece of machinery is being abused and it will only last so long...