DNP and its negative effect on your thyroid

[xxsuprman22xx]

I ran Dnp the last time nearly 6 months ago.

2 weeks before DNP my dnp my tsh levels were at .89

Directly after finishing 2 weeks on DNP my levels were at 3.46

a few months later, at 2.47

now as of last week its at 1.15

Seems like nobody gets bloodwork on this stuff, just thought id share.

BTW everything else was normal except my bp came down a bit.

 

[Conciliator]

What was the negative effect? It looks like all those numbers are in the normal range. Also, did you get tested for actual T3 or T4? If so, what were the numbers?

AAS and DNP have a similar effect on thyroid, through a similar mechanism of action. While androgens reduce the concentration of thyroid binding globulin (TBG), DNP occupies thyroid binding proteins, which has the same result... less protein to bind to thyroid. This may initially result in higher serum levels and accelerated clearance, but after a short term alteration in thyroid function a new steady state is soon reached in which thyroid function is normal, despite potentially reduced serum levels of total T4 and total T3. As one paper on DNP explained, "this action could lower the total hormone concentration in serum but should have no persistent effect on thyroid function". This means that even though the level of thyroid hormones in the blood can potentially be lower than normal, thyroid function will still be normal. What I've seen happen most of the time, however, is that thyroid levels hardly change.

There's a case study that's often posted as evidence for thyroid dysfunction from DNP, but I'm of the opinion that the bodybuilders in question had low thyroid levels not because of the DNP, but because they were taking T3 during their cycle. Exogenous T3 definitely will suppress endogenous production. I had a Norwegian translate the paper and it was unclear why they had low thyroid levels. They didn't test for reverse thyroid when they could have, which would have made the cause clearer.

I also have a friend who's a doctor of internal medicine who ran 600mg/day of crystal DNP for 3-4 months (went from 320 lbs down to the mid 200's). He gave himself frequent blood tests and said his thyroid didn't budge. I've heard feedback from several others who did blood work showing the same thing. I'm just not convinced that DNP results in any thyroid dysfunction.

 

[Newman]

Interesting.

 

[RationalGaze]

First off, TSH doesn't mean a damn thing unless you have your T3 and T4 levels tested. TSH is Thyroid Stimulating Hormone, it is not produced by the thyroid. You can have a high or low TSH and have normal or abnormal T3/4 levels.


Also, if you were dieting during your DNP run, that will negatively affect your thyroid levels. Chances are good you were hypocaloric and thus lowering your thyroid levels through dieting alone.

 

[gelatine]

I also have a friend who's a doctor of internal medicine who ran 600mg/day of crystal DNP for 3-4 months (went from 320 lbs down to the mid 200's). He gave himself frequent blood tests and said his thyroid didn't budge. I've heard feedback from several others who did blood work showing the same thing. I'm just not convinced that DNP results in any thyroid dysfunction.

When doctors start doing it, I wonder if the FDA would ever take a second look? I don't think they go from ban to not ban very often though, if ever.

 

[Thewhite9t]

When doctors start doing it, I wonder if the FDA would ever take a second look? I don't think they go from ban to not ban very often though, if ever.

The DNP ban will never be repealed. It's simply too dangerous and out of the question for beginners.

It is a good tool in an advanced bodybuilder's arsenal, but it's definately for the better that it isn't widely available.

 

[gelatine]

The DNP ban will never be repealed. It's simply too dangerous and out of the question for beginners.

It is a good tool in an advanced bodybuilder's arsenal, but it's definately for the better that it isn't widely available.

Why do you say that? When it was prescribed in the 1930's, how many people overdosed? Practically none. DNP is very safe at lower dosages. The cataracts, which were the basis of the FDA's decision to ban, are a side effect that should be considered between a doctor and a patient, and there are plenty of allowed drugs that can cause troubles just as severe.

 

[Thewhite9t]

Why do you say that? When it was prescribed in the 1930's, how many people overdosed? Practically none. DNP is very safe at lower dosages. The cataracts, which were the basis of the FDA's decision to ban, are a side effect that should be considered between a doctor and a patient, and there are plenty of allowed drugs that can cause troubles just as severe.

C'mon now. We all know that with dieting drugs, more=better.

People can't even handle ephedra. This stuff is far more potent and dangerous.

Idiots would be taking 900mg and running outside in the sun on a 90 degree day. They will also be using it with diuretics, including alcohol in excess.

I mean it would be awsome if everyone was responsible and made well informed decisions, but that just isn't the case.