Ethyl Oleate safety

[viveutvivas]

I am looking for sources on the safety of Ethyl Oleate (common solvent for underground gear).

Are we causing long term organ and heart damage? EO is an FAEE, for those not familiar with the link.

Fatty acid ethyl esters: potentially toxic products of myocardial ethanol metabolism.

Beckemeier ME, Bora PS.

Veterans Affairs Medical Center, GRECC Service, St. Louis, Missouri 63108, USA.
Abstract

The chronic consumption of alcohol has proven detrimental to heart tissue and can lead to alcohol-induced heart muscle disease, a condition which may result in arrhythmias, cardiomegaly, and congestive heart failure. A search for the molecular mechanism underlying observed alcohol-induced end-organ damage, such as that seen in heart, has lead to the discovery of a nonoxidative pathway for the metabolism of alcohol in several human tissues including heart, brain, pancreas, and liver. It has been revealed that nonesterified fatty acids are esterified with ethanol to produce fatty acid ethyl esters (FAEE), neutral molecules which can accumulate in mitochondria and impair cell function. The observation that FAEEs are synthesized at high rates in the heart, and other organs that lack oxidative ethanol metabolism, provides a plausible link between the observed tissue damage, the ingestion of alcohol, and the subsequent development of alcohol-induced heart muscle disease. The synthesis of FAEEs are catalyzed by FAEE synthase enzyme, four of which have been characterized and purified to homogeneity from the human myocardium. Further analysis of these FAEE synthase enzymes opens up a new possibility to characterize and map a gene for alcohol-induced end-organ damage, such as that observed in heart and other organs. FAEEs have been found to be important metabolites of alcohol and are most commonly accumulated in those organs which are damaged by alcohol abuse, i.e. heart. It may now be important to establish a genetic link between alcohol abuse and alcohol-induced heart muscle disease in order to understand the mechanism of alcohol-induced cardiomyopathy.

 

[Bolan]

I agree, the old school gear was simply made in Cottonseed oil...Just like What you get in your Upjohn or Watson HRT meds....
IMO UGL people take recipes off the net to brew, and want something to flow easier through a pin. So EO is the answer.....But the majority of UGLS do not have the chemistry back ground to make gear hold without crashing...so they use EO for that also.

 

[wardog50]

I agree with both of you.

A campaign needs to be started "EO has to GO". lol.

But seriously it is way way overused and a lot of guys dont even say that they use it.
Users find out afterward from adverse reactions.

Wardog

 

[summersgold]

Ethyl Oleate is not approved for injection use by the FDA. However it is approved for use in some European countries. It would be interesting to know why these European countries approved it. I read somewhere that it is metabolized into alcohol in the liver.

 

[viveutvivas]

Ethyl Oleate is not approved for injection use by the FDA. However it is approved for use in some European countries.

Which ones?