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Found some interesting information today and figured I'd share with ya'll... recently was prescribed ezetemibe to help lower my apoB (LDL is "fine" hovering around 100-110 usually) and planned to do 10mg EOD and evaluate levels after next lab run to see effects. After reading this I'm going to split the tab and take 5 per day. Came across a separate article that used only 2.5mg and found it to be an effective dose, and assuming one's LDL/apoB may not be extreme this could be an option as well. I don't think 2.5mg is a great option as the tabs are super small already so I'm going with 5mg.
"Results: A total of 272 patients were prescribed ezetimibe; 86 received 5 mg and 186 received 10 mg. Of those 272 patients, 197 had evaluable baseline and posttreatment LDL-C (55 taking the 5-mg dose and 142 taking the 10-mg dose). The effects of ezetimibe 5 and 10 mg on all lipid parameters were similar. Ezetimibe 10 mg reduced LDL-C by 26.1%, whereas 5 mg reduced LDL-C by 25.8%. The percentages of patients achieving goal LDL-C were similar: 61.8% (5 mg) and 60.5% (10 mg)."
https://pubmed.ncbi.nlm.nih.gov/18837641/
"Our study demonstrates that ezetimibe 2.5 mg is an effective dose. From a comparative effectiveness perspective, the 2.5-mg dose provides the greatest value without a clinically meaningful loss of efficacy. Furthermore, this study adds to the evidence base that supports splitting the 5-mg tablet, as the 2.5-mg dose appeared highly effective. With annual ezetimibe/simvastatin and ezetimibe sales of $4 billion, broad implementation of either of these split-tablet ezetimibe dosing strategies could result in an annual cost savings of billions of dollars."
https://www.pharmacytimes.com/view/ajpb_10aug_baruch_261-266
"Results: A total of 272 patients were prescribed ezetimibe; 86 received 5 mg and 186 received 10 mg. Of those 272 patients, 197 had evaluable baseline and posttreatment LDL-C (55 taking the 5-mg dose and 142 taking the 10-mg dose). The effects of ezetimibe 5 and 10 mg on all lipid parameters were similar. Ezetimibe 10 mg reduced LDL-C by 26.1%, whereas 5 mg reduced LDL-C by 25.8%. The percentages of patients achieving goal LDL-C were similar: 61.8% (5 mg) and 60.5% (10 mg)."
https://pubmed.ncbi.nlm.nih.gov/18837641/
"Our study demonstrates that ezetimibe 2.5 mg is an effective dose. From a comparative effectiveness perspective, the 2.5-mg dose provides the greatest value without a clinically meaningful loss of efficacy. Furthermore, this study adds to the evidence base that supports splitting the 5-mg tablet, as the 2.5-mg dose appeared highly effective. With annual ezetimibe/simvastatin and ezetimibe sales of $4 billion, broad implementation of either of these split-tablet ezetimibe dosing strategies could result in an annual cost savings of billions of dollars."
https://www.pharmacytimes.com/view/ajpb_10aug_baruch_261-266
