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Fish Oil = A-Fib?

whacked

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Fish oil supplements linked with heart rhythm disorder​

29 Apr 2021
Risk Factors and Prevention
Cardiovascular Pharmacotherapy


Sophia Antipolis, 29 April 2021: Omega-3 supplements are associated with an increased likelihood of developing atrial fibrillation in people with high blood lipids. That’s the finding of a study published today in European Heart Journal - Cardiovascular Pharmacotherapy, a journal of the European Society of Cardiology (ESC).1
“Currently, fish oil supplements are indicated for patients with elevated plasma triglycerides to reduce cardiovascular risk,”2 said study author Dr. Salvatore Carbone of Virginia Commonwealth University, US. “Due to the high prevalence of elevated triglycerides in the population, they can be commonly prescribed. Of note, low dose omega-3 fatty acids are available over the counter, without the need for a prescription.”
Some clinical trials have suggested that omega-3 fatty acids may be associated with an increased risk for atrial fibrillation, the most common heart rhythm disorder. People with the disorder have a five times greater likelihood of having a stroke.3
These studies tested different formulations of omega-3 fatty acids at different doses. The authors therefore performed a comprehensive meta-analysis of randomised controlled trials to answer the question of whether fish oils were consistently related to a raised risk for atrial fibrillation.
The analysis included five randomised controlled trials investigating the effects of omega-3 fatty acid supplementation on cardiovascular outcomes. Participants had elevated triglycerides and were either at high risk for cardiovascular disease or had established cardiovascular disease. A total of 50,277 patients received fish oils or placebo and were followed up for between 2 and 7.4 years. The dose of fish oils varied from 0.84 g to 4 g per day.
The researchers found that omega-3 fatty acid supplementation was associated with a significantly increased risk for atrial fibrillation compared to placebo with an incidence rate ratio of 1.37 (95% confidence interval 1.22–1.54; p<0.001).
Dr. Carbone said: “Our study suggests that fish oil supplements are associated with a significantly greater risk of atrial fibrillation in patients at elevated cardiovascular risk. Although one clinical trial indicated beneficial cardiovascular effects of supplementation,4 the risk for atrial fibrillation should be considered when such agents are prescribed or purchased over the counter, especially in individuals susceptible to developing the heart rhythm disorder.”
 

New Smidt Heart Institute Research Suggests High Doses of Omega-3 Fatty Acids Could Increase the Risk of Developing Atrial Fibrillation
Smidt Heart Institute researchers have found that taking high doses of fish oil supplements—specifically one gram or more per day—may increase the risk of developing atrial fibrillation, an abnormal heart rhythm disturbance with potentially serious complications. The new study was published today in the peer-reviewed journal of the American Heart Association Circulation.

Atrial fibrillation is the most common type of abnormal heart rhythm, causing the heart to contract irregularly and, sometimes, too quickly. It is estimated to affect 33 million people worldwide and can lead to blood clots, stroke, heart failure and other heart-related complications.

According to the 2012 National Health Interview Survey, it is estimated that 7.8 percent of American adults, almost 19 million people, take fish oil supplements.

Recent research led by Christine M. Albert, MD, MPH, a professor of Cardiology and chair of the Department of Cardiology in the Smidt Heart Institute, suggested neither vitamin D nor the omega-3 fatty acids found in fish oil prevent the development of atrial fibrillation. However, other clinical trials conducted outside of Cedars-Sinai pointed to an elevated risk of developing atrial fibrillation in patients treated with omega-3 fatty acids, causing confusion among clinicians and patients alike.

To further explore the potential reasons for differences between the results of these studies, Albert and team performed a meta-analysis, which combines the results of multiple scientific studies. This analytical comparison between studies suggested that the risk of developing atrial fibrillation is dependent on the dose of omega-3 fatty acids.

Although there's strong evidence that omega-3 fatty acids can significantly reduce blood triglyceride levels and arthritis pain, most experts agree it's best to get omega-3 fatty acids from eating fish several times a week.

“Our goal was to bring clarity, answers and actionable information to the broader medical field and to patients,” said Albert, the Lee and Harold Kapelovitz Distinguished Chair in Cardiology. “In this instance, the results suggest that there may not be a straightforward answer to, ‘Is fish oil good or bad for atrial fibrillation?’ but instead, the answer may depend on the dose.”

Data
Key highlights from the research study include:

  • Data was reviewed from 81,210 patients enrolled in seven clinical trials, including one conducted at Cedars-Sinai. The average age of patients enrolled in these trials was 65 and 39% were women.
  • Out of these patients, 72.6% were in clinical trials testing less than or equal to one gram of omega-3 fatty acids per day and 27.4% were enrolled in clinical trials testing more than one gram of the supplement per day.
  • Patients who took more than one gram per day of omega-3 fatty acids had a 49% increased risk of developing atrial fibrillation, compared to just 12% of patients who took one gram or less of the supplement per day.

Treatment Recommendations

Now armed with this information, Albert has recommendations for clinicians, researchers and patients.
If clinicians offer high-dose omega-3 fatty acid supplements, Albert says they should first discuss the potential risk of developing atrial fibrillation, and patients should be informed about the potential signs and symptoms of the condition so an early diagnosis can be made and coupled with appropriate treatment.

Researchers, Albert says, should systematically monitor patients for atrial fibrillation and related adverse outcomes to better define risk-to-benefit ratios in studies examining the effects of omega-3 fatty acid supplements.

“For patients, the risk of developing atrial fibrillation appears to be relatively small for those taking one gram or less of fish oil per day,” said Albert. “Taking more than one gram of fish oil per day is something you should only do following your doctors’ advice.”

The study, which combined previously published results, was unable to determine whether there are patients that might be more susceptible to developing atrial fibrillation when taking fish oil.

The risk of developing atrial fibrillation increases with age and is more common in men than in women. In addition to age and gender, additional risk factors include high blood pressure, coronary artery disease, heart failure, heart valve defects, obesity and diabetes.

The condition is also more likely to happen during an infection or right after surgery. Stress, caffeine and alcohol may also set off attacks. People who do a lot of repeated vigorous endurance exercises, such as running marathons, can also develop atrial fibrillation. How fish oil may alter the risk of atrial fibrillation in marathon runners or in individuals with other risk factors remains unknown.
 
I hate it when they state shit like this.

"Patients who took more than one gram per day of omega-3 fatty acids had a 49% increased risk of developing atrial fibrillation, compared to just 12% of patients who took one gram or less of the supplement per day."

Doesn't that mean that if my "risk" were 1%, my "risk" on omega's is a measly ~1.5%?
 
Interesting…
But I can also find 5 studies that say the complete opposite.

Fish oil is one of the most complex supplements too and has somewhat been a “joke” (I mean that in the nicest way) of the university testing system because of results like this. 3 studies say you’re going to die now, 3 studies say you’ll live till 150. OVERALL, I feel like we have enough data to show that the addition of EPA/DHAs in an ALREADY HEALTHY DIET is proven to be beneficial.
 
Odd how at a time when people are getting a lot of heart issues from a certain something, they come out with a “study” claiming the fish oil is a problem….
This is exactly what I thought right away. Couldn’t be the untested, rushed jab!!! Must be the omegalyze!!!! 😂😂😂
 
I dated a nurse a few years ago that started having heart issues and found it was due to the fish oil she had just started taking. And once she stopped the issues went away. But the underlying cause may not have. But that was fairly rare from me reading back then. While AFIB may be something to look into. I am always more interested in what the longevity is with people that use a treatment. when i look at cholesterol meds they lower the risk of heart attack by lowering cholesterol. But the life span does not really increase in most studies i see as people succumb to other illnesses instead. A benefit in one area is not necessarily a benefit over all.
 
These folks were already at an elevated risk; likely obese. Ofc adding more fat (whether good or bad fat) would have those results. People who eat clean and train reguarlary should give two shits about this study.
 

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