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introduction of hgh and testosterone therapy


New member
May 30, 2009
> is HGH?
> Human Growth
> Hormone is a hormone produced in the pituitary gland and is
> made up of 191 amino acids. HGH secretion reaches its peak
> in the body during adolescence. This makes sense because HGH
> helps stimulate our body to grow. As we age or body produces
> less and less HGH. By age 60 our body produces approximately
> 75% less HGH than at age 20.
> What
> role does HGH play in our body?
> Human growth
> hormone and IGF-1 have been shown to play a significant role
> in:
Fat burning
> Growth of all
> tissues
> Increased Energy level
> Tissue repair
> Whole body healing
> Cell replacement
> Bone strength
> Brain function
> Sexual function
> Organ health and
> integrity
> Enzyme production
> Integrity of hair,
> nails, skin and vital organs
> Basically,
> anything that goes on in your body is in some way tied to
> HGH. This is why HGH is often called the "fountain of
> youth". Elevated HGH levels are what make you feel
> young again.
> As important as
> HGH is, it does not last long in our bloodstream. In just a
> few short minutes our liver absorbs HGH and converts it into
> growth factors. IGF-1 (Insulin-like Growth Factor 1.) is the
> most important of these growth factors. You can think of HGH
> as the hormone that gets the ball rolling, but IGF-1 does
> most of the work.
> What
> are the benefits of HGH replacement
> therapy?
> While numerous
> studies have been done on the effects of HGH injections, the
> most ground breaking study was done by Dr. Rudman and
> published in the New
> England Journal of Medicine on July 5, 1990. The
> journal reported that men who had taken HGH injections had
> shown an 8.8 percent gain in lean body mass with a 14
> percent loss in body fat - and the subjects who received HGH
> injections had an 8.8 percent increase in lean body mass.
> If you look at all
> the studies that have been done on HGH injections you get
> the following list of benefits:
> 8.8% increase in
> muscle mass on average after six months
> 14.4% loss of fat
> on average after six months
> Higher energy
> levels
> Enhanced sexual
> performance
> Regrowth of heart,
> liver, spleen, kidneys and other organs that shrink with age
> Greater cardiac
> output
> Superior immune
> function
> Increased exercise
> performance
> Better kidney
> function
> Lowered blood
> pressure
> Improved
> cholesterol profile, with higher HDL and lower LDL
> Stronger bones
> Faster wound
> healing
> Younger, tighter,
> thicker skin
> Hair regrowth
> Wrinkle removal
> Elimination of
> cellulite
> Sharper vision
> Mood elevation
> Increased memory
> retention
> Improved sleep
> What
> are the possible negative side
> effects?
> Anytime you introduce a large amount of a foreign hormone
> into the body there is the risk of side effects. In Dr.
> Rudman's study he found that some of the patients
> suffered from carpal tunnel syndrome and gynecomastia
> (enlarged breasts). Dr. Rudman believed that with less HGH
> the side effects would go away, but tragically he died
> before he could test his theory.
> What
> can be done to prevent these negative side
> effects?
> The cause of
> carpal tunnel syndrome is usually linked to repetitive work
> related tasks. Since this is not the case during HGH
> replacement therapy, usually little can be done to prevent
> it. The good news is that the development of carpal tunnel
> syndrome only rarely occurs and when symptoms do occur they
> are usually mild and likely to be temporary. In these cases
> treatment includes rest, anti-inflammatory drugs, and a
> metal splint. Even if a patient wears a splint that has been
> prescribed, he or she should avoid the activities that
> normally causes or could aggravate the injury. Where
> this is not possible, patients should wear the splint after
> work and particularly during sleeping hours.
> Gynecomastia
> is a medical term that comes from the Greek words for
> "woman - like breasts." Though this oddly named
> condition is rarely talked about, it is actually quite
> common. Gynecomastia affects an estimated 40% to 60% of men.
> Fortunately it is easily treated with anti-estrogen
> medications like Clomid, (Clomiphene Citrate) or Armidex,
> (Anastrozole) or Nolvadex (tamoxifen).
> What
> is the take-home message?
> The take-home message is that the
> decline of growth hormone with age can be reversed. Even if
> growth-hormone releasing hormone activity declines, or
> somatostatin increases, or receptors become less responsive
> to growth hormone, it can all be overcome by the
> administration of growth hormone or growth-hormone
> releasers.
> Those
> who produce little or no growth hormone show mental and
> physical changes that are characteristics of aging,
> including a reduced sense of well-being, plus lower energy,
> vitality and capacity for work. In addition, they also
> exhibit mood swings, anxiety, depression and increased
> social isolation. Important physical signs are an increase
> in body fat, especially around the waist (apple-shaped
> rather than pear-shaped), a decrease in muscle mass, and
> thin, wrinkled, or prematurely damaged skin.
> In one
> study Dr. Lena Wiren, a psychologist who evaluated the
> patients, was quoted as saying, "We called it the
> Lazarus effect," she says. "We woke them up. With
> some patients, it was like giving them a kick in the back.
> Their lives changed within a few weeks." The treatment
> went on to change the lives of everyone who participated in
> the program. "Nobody wants to stop treatment," she
> says. "Sometimes it is not even the patient who notices
> the difference it is making. Rather it is their wives or
> children or friends at work."
> TO
> Hgh &
> Testosterone
> Therapy
> On July 5, 1990, the prestigious
> New
> England Journal of Medicine published a clinical
> study on a drug that sent shock waves throughout the world.
> It was instantly hailed as a fountain of youth. In a scene
> that seemed like something out of the movie Cocoon, injections of
> synthetic human growth hormone-a substance naturally
> produced by the pituitary gland-had turned twelve men, ages
> sixty-one to eighty-one, with flabby, frail, fat-bulging
> bodies, into their sleeker, stronger, younger selves. In
> language rarely used in conservative medical journals,
> Daniel Rudman, M.D., and his colleagues at the Medical
> College of Wisconsin wrote: “The effects of six months of
> human growth
> hormone on lean body mass and adipose-tissue mass were
> equivalent in magnitude to the changes incurred during 10 to
> 20 years of aging.”
> In interviews with
> reporters, the men in the study and their wives reported
> other startling changes. The gray hair of a
> sixty-five-years-old man was turning black. The wife of
> another man had trouble keeping up with her newly energized
> husband even though she was fifteen years younger. A third
> man, who saw the wrinkles disappear on his face and hands,
> was now opening jars with ease, passing younger people on
> the street, and gardening for hours on end. Some of the
> users and their spouses made sly references to reinvigorated
> sex lives. What happened to the control group? In group 2,
> as they were called in the study, “there was no
> significant change in lean body mass, the mass of adipose
> tissue, skin thickness, or bone density during treatment.”
> In other words, they continued aging on schedule.
> Drugs and therapies
> that claim to reverse aging are nothing new. For decades
> youth seekers have trekked to the four corners of the world
> seeking youth and immortality. Recent examples include Ana
> Asland’s clinic in Rumania for injections of Gerovital H3,
> which is essentially the same Novocain your dentist uses.
> Konrad Adenauer, Gloria Swanson, Groucho max, and more than
> 50,000 lesser-cells at Clinic La Prairie in Switzerland .
> Others swear by ginseng or placental extract or nucleic acid
> therapy, which unleashed a craze for eating RNA-rich
> sardines. While some of these therapies might have genuine
> merit, none of them has passed the gold standard of drug
> testing: controlled, randomized, double-blind clinical
> study. Today there is immense interest in the hormone
> melatonin, released by the pineal gland in the brain. But
> melatonin has yet to be tested in
> double-blind trials in human beings. The only
> age-reversing drug that has passed placebo-controlled
> double-blind clinical trials with flying colors is human
> growth hormone. Not once, but many times over.
> Following up his own work, Rudman
> found that HGH given to twenty-six elderly men regrew the
> liver, spleens, and muscles that had shrunken with age back
> to their youthful sizes. Improved muscle strength , he
> pointed out, could make the difference between someone’s
> being on his feet or being confined to a wheelchair, between
> being spoon-fed or cooking a meal, between living
> independently or living in a nursing home. “The overall
> deterioration of the body that comes with growing old is not
> inevitable,” he concluded. “We now realize that some
> aspect of it can be prevented or reversed.”
> Rudman’s landmark discovery opens
> the floodgates to the point that there are now thousands of
> studies in the world medical literature documenting the
> benefits of growth hormone therapy. The National Institute
> on Aging has funded a multimillion-dollar effort in the nine
> medical centers that will run for five years to test whether
> human growth hormone and other atrophic factors- defined as
> substances that promote growth or maintenance of tissues-
> can reverse or retard the aging process. In 1992 medical
> researchers at Stanford University stated, “It is possible
> that physiologic growth hormone replacement might reverse or
> prevent some of the ‘inevitable’ sequel of
> aging.”
> But many people are not waiting for
> the result of these studies. In this country and abroad,
> doctors at dozens of clinics are treating thousands of old
> and middle-aged people who wish to erase the effects of
> aging. Hundreds of case histories have now become available,
> some of which you will read about in the coming
> chapters.
> In August 1996, the Food and Drug
> Administration approved HGH for long-term replacement
> therapy in adult with growth hormone deficiency. Before that
> the only indication had been treatment of adult children who
> failed to grow due to lack of growth hormone. The new FDA
> approval now opens the door for physicians to prescribe HGH
> to their GH-deficient aging patients. As Silvio Inzucchi
> notes in the January 15, 1997 issue of Hospital Practice,
> “Growth hormone deficiency is now formally recognized as a
> specific clinical syndrome, typified by decreased muscle
> mass, increased body fat (predominantly at intra-abdominal
> sites), decreased exercise capacity, osteopenia, abnormal
> lipid profiles, and diminished well-being. The critical
> reader will recognize that most, if not all, of these sings
> and symptoms are common in an aging patient
> population.”
> At this writing, Eli Lilly and
> Pharmacia Upjohn have received FDA approval to market HGH
> for growth hormone deficiency in adults and Genentech
> expects to receive approval soon.
> No doubt other manufacturer of HGH
> will apply for and receive permission to market the drug to
> adult patients. This competition will greatly reduce the
> price of the drug (which is already falling sharply),
> putting it within reach of the most people who are concerned
> about their health and aging.
> Incredible though it may seem, the
> slow decline in appearance and function that we call aging
> may not be fixed in our genes or part of human destiny. In
> fact, as the elderly men in Rudman’s experiment and the
> men and women we met at Cancun have shown, aging not only
> can be arrested but can actually be reversed. What we now
> call aging appears to be due in a large part to the drastic
> decline of growth hormone in the body after adulthood. At
> the age twenty-one, the normal level of circulating HGH is
> about 10 milligrams per deciliter of blood, while at the age
> sixty-one it is 2 milligrams per deciliter- a decrease of 80
> percent! It is growth hormone that grows the cells, bones,
> muscles, and organs of young children, and it is the falling
> level of growth hormone after age thirty that slowly rob us
> of our youth.
> By the age seventy to eighty,
> according to Rudman, 38 percent of the population is as
> deficient in growth hormone as children who fail to grow
> normally because of their hormonal lack. But the prognosis
> for the falling aged person and the stunted child is equally
> good. As Rudman wrote in a 1991 article in “Hormone
> Research”, in terms of restoring hormonal levels, “the
> elderly hyposomatotropic (gh-deficient) subject is as
> responsive to human growth hormone as th GH-deficient child.
> Thus, the GH menopause can be reversed by exogenous
> HGH”.
> Most of what we know
> about growth hormone in adulthood comes from research on
> people who are growth hormone deficient because their
> pituary glands have been damaged by disease or have been
> removed because of cancer. These people suffer a
> constellation of symptoms that look remarkably like aging.
> The results of growth hormone replacement in these patients,
> as shown in double-blind, placebo-controlled studies in many
> different countries around the world can be reversed. In
> some cases, as you will see, the results were spectacular,
> with some patients going through changes almost as
> remarkable as those portrayed in the film “Awakenings”.
> But unlike those in the movie, the changes in these patients
> are permanent as long as they continue to take the hormone.
> HGH is the ultimate anti-aging
> therapy. It affects almost every cell in the body,
> rejuvenating the skin and bones, regenerating the heart,
> liver, and kidneys, bringing organ and tissue function back
> to youthful levels. It is an anti-disease medicine that
> revitalizes the immune system, lowers the risk factors for
> heart attack and stroke, improves oxygen uptake in emphysema
> patients, and prevents osteoporosis. It is under
> investigation for a host of different diseases from
> osteoporosis to post polios syndrome to AIDS. It is the most
> effective anti-obesity drug ever discovered, revving up the
> metabolism to youthful levels, resculpting the body by
> selectively reducing the fat in the waist, abdomen, hips,
> and thighs, and at the same time increasing muscle mass. It
> may be the most powerful aphrodisiac ever discovered,
> reviving flagging sexuality and potency in older men. It is
> cosmetic
> surgery in a bottle, smoothing out facial wrinkles;
> restoring the elasticity, thickness, and contours of
> youthful skin; reversing the loss of extra-cellular water
> that makes old people look like dried up prunes. It has
> healing powers that close ulcerated wounds and regrow burned
> skin. It is the secret ingredient in the age-defying bodies
> of weight lifters and it enhances exercise performance,
> allowing you to do higher-intensity workouts of longer
> duration. It reverses the insomnia of later life, restoring
> the “slow wave” or deepest level of sleep. And it is a
> mood elevator, lifting the spirits along with the body,
> bringing back a zest for life that many people thought was
> lost forever. The latest research included in this book
> shows that it holds promise for the treatment of that most
> intractable and terrifying disease of aging ---
> Alzheimer’s.
> While growth hormone
> has an extraordinary range of age-reversing effects seen
> with no other substance, replacing hormones that decline
> with age is not new. The oldest continuing anti-aging
> experiment is hormone replacement therapy with estrogen or a
> combination of estrogen and progesterone in post menopausal
> women. Premarin, a brand name of estrogen is the single most
> prescribed drug in the United States. The benefits of female
> hormone replacement range from sharply decreased incidence
> of osteoporosis to vaginal lubrication to a 50 % decrease in
> heart attack and strokes. A far smaller but growing number
> of men (and women also) are now taking testosterone to build
> muscles, increase strength, and recharge their sexual
> batteries. Two other hormones, DHEA (dehydroepiandrosterone)
> and melatonin, which also decrease with age, have been shown
> to have broad anti
> aging and anti-disease effects on the body. All these
> hormones should be part of an anti-aging program.
> The
> Testosterone Syndrome: Eugene
> Shippen,M.D
> If I told you that one key substance
> in the body is more powerful than any other health factor,
> is more closely linked to risk of illness if and when
> deficiency occurs, is more misunderstood, more improperly
> used, and more tragically underused than any other, what
> would it be? Testosterone! I have studied it, prescribed it,
> and watched the responses of my patients-hundreds of them. I
> challenge anyone to find a more diversely positive factor in
> men’s health. When normally abundant, it is at the core of
> energy, stamina, and sexuality. When deficient, it is at the
> core of disease and early demise.
> Testosterone deficiency has been an
> unrecognized syndrome that impacts every sinew and cell in
> the body. It is powerfully linked to nearly every major
> degenerative disease. Use of this remarkably healthy hormone
> could reverse suffering and prevent early death. My research
> uncovered a mountain of medical literature that has been
> basically ignored supporting its benefits.
> I was taught that there was no male
> menopause and for years accepted that as fact. A series of
> events in my own health and the discovery that several
> pioneering physicians held entirely different points of view
> changed my mind and transformed my conception of age-related
> illness and preventive medicine. Until that point, I had
> seen aging as an unrelenting natural process that it was
> best to accept gracefully. Preventive medicine was an
> attempt to treat or modify specific risk factors that, like
> a sleeping lion, would jump up and bite you later in life.
> My perspective changed dramatically.
> Clearly, preventive medicine would widen in scope if it
> turned out aging was reversible. And, to a significant
> extent, it is. The male menopause, a grim milestone in the
> middle passage of a man’s life, can be rolled back.
> Testosterone decline is at the core
> of that male menopause (and a key element to female
> menopause as well). Naturally, the two sexes have a
> different experience of midlife menopausal change. In women,
> there is an explosion of in-your-face symptoms, while
> men’s very similar symptoms sneak in the back door
> unexpectedly like a thief in the night. Too often, loss of
> energy, ambition, sexual drive, and a host of minor symptoms
> are written off as “burnout” or depression.
> Women, meanwhile, have already
> learned that hormone replacement results in reversal of the
> physical changes of menopause. Men, confronted by an
> information vacuum, still need to make the same discovery.
> Do
> You Know What A Hormone Is?
> Allow me to define a word, without
> which the rest of this book is meaningless. Hormone.
> A hormone is a chemical
> substance produced in one part or organ of
> the body that starts or runs the activity of an organ or a
> group of cells in another part of the body. Testosterone,
> estrogen, insulin, adrenalin, cortisone-these are a few of
> the hormones found in most peoples vocabularies and at least
> vaguely understood. Hormones can also be converted from one
> hormonal substance into another out in the tissues of the
> body. This is a newer concept, which later in the book will
> prove vital, and is referred to as intracrinology.
> In the last few years, the popular
> anti-aging literature has given many people a familiarity
> with such hormones as DHEA, growth hormone, and melatonin.
> They are generally important substances, and perhaps some of
> you are already familiar with the idea that the levels of
> hormones can affect our actual (as opposed to chronological)
> rate of aging.
> Every cell in the human body is
> programmed by hormonal messengers. Hormones tune our
> systems-or detune them. We are hormonal creatures to at
> least as great an extent as we are oxygen-breathing
> creatures or blood-circulating creatures. We could not live
> a day or hardly even an hour without properly balanced
> hormonal input. Balance is the crucial word. Too much of the
> more important hormones would burn us out metabolically at a
> fantastic rate. Too little and our systems begin to slowly
> shut down.
> Think back when you were young. If
> you were like most people, you reached your physical peak in
> your late teens or early twenties. It was a time of
> rambunctious energy that resisted every effort to squander
> it away. Late nights, too much work and too much play, and,
> for many of us, far too much eating and drinking-all this
> produced very little in the way of untoward effects. For
> many twenty-year-olds, burning the candle at both ends is
> not a danger; it’s an art form. Pushing past every
> reasonable limit, we recharged our cellular batteries as
> fast as we drained them. How were our organ systems and
> indeed, every cell in our bodies able to keep up with the
> brutal pace? Hormones! We were in hormone heaven.
> The optimal function of every cell
> requires optimal hormonal input-and we had it. Logically,
> therefore, any decline in hormonal activity from youthful
> norms will result in suboptimal cellular activity. Does that
> seem reasonable?
> We know that it is. There are many
> reasons hormones change, including illness, stress, the
> autoimmune destruction of our glands, and of course, the
> natural decline of aging. Any doctor who has carefully
> charted the hormonal changes of his patients knows the
> significant, long term hormonal decline leads irresistibly
> toward illness, fatigue, malaise, and further aging.
> And any doctor who looks for
> hormonal decline will find hormonal decline. Most of the
> major hormone system drops significantly and steadily from
> year to year and decade to decade. It is one of the most
> important parts of the steady downward spiral into old age
> and debility.
> The
> Importance of the Male Menopause
> It would be impossible to
> overemphasize the devastating effects that the menopause has
> on millions of men and women. Doctors know because people
> come and sit in our offices and tell us secrets that they
> wouldn’t even whisper to their spouses. And once you’ve
> listened for a while to people telling you that their sex
> lives are crumbling, their energy is shattered, their health
> is growing shakier by the year-and one soon finds out that
> they’re right on that point-one feels a very real
> compulsion to do something about it.
> Is all this unpleasant change
> menopause? A whole lot of it is. Heart disease, high blood
> pressure, diabetes, arthritis, osteoporosis- indeed, most of
> the major risk factors for dying –are all intimately
> related to hormonal changes. To a surprising degree many of
> these dreadful conditions reverse themselves when a proper
> balancing of the hormones in the body is combined with
> sensible diet. As you’ll see the hormonal balancing can be
> achieved either by various natural boosting techniques or by
> actual hormonal replacement.
> To say that the menopause is natural
> seems like a trivial distinction in the face of these
> calamities. Death is natural and inevitable; too, many of us
> would like to postpone it. Moreover, I think I speak for
> most people when I say we would like to keep out youthful
> vigor throughout our lives, right up to the end. The real
> purpose of this book is to help make that possible.
> Things
> That Happen to Real People
> Consider two people, a man and a
> woman, each in their middle span of years.
> A Very Common
> Story
> Tim W. is a patient of mine,
> fifty-five year old lawyer from central Pennsylvania, whose
> complaints, when I first heard them, sounded very much like
> “normal” aging Tim wasn’t sick, he wasn’t breaking
> down physically or emotionally, he wasn’t sexually
> nonfunctional.
> But he wasn’t well either. Tim
> came to me about four years ago because there were a lot of
> physical changes in his life, which taken one by one
> didn’t sound particularly threatening or impressive but
> taken together were turning him into a different person.
> He had noticed the first changes
> when he was around forty. He had put it down to overwork.
> His practice was doing well, and that meant a lot of
> evenings and Saturday afternoons at the office. Result:
> sometimes he simply didn’t feel like getting up in the
> morning. And there were other changes too. His interest in
> sex had declined. A strange veneer of irritability and
> depression was beginning to coat the surface of his life.
> Tim W. had always been athletic, but
> there were changes here as well. Jogging had become a chore,
> not something that boosted his energy. Tennis and golf were
> less exhilarating.
> As Tim’s forties advanced, all
> these changes did too. The faint shadow of depression over
> everything he did seemed to be growing. He was frequently
> tired, had difficulty concentrating on new cases, and felt
> little desire to initiate fresh approaches. He had realized
> he had become more passive. His television set was a real
> buddy now.
> And sexually he had the first
> fearful sense that something irreversible was happening.
> Tim’s libido had really sunk. Occasional sexual encounters
> with his wife were now very occasional. When they went on
> vacation, things would perk up, which allowed him for a
> little while longer to maintain the illusion that the only
> problem was overwork. But Tim couldn’t help noticing
> other, subtler sexual changes. For one thing, he no longer
> had early morning erections. And, when he had an orgasm,
> there was a radical drop-off in the volume of ejaculate.
> Moreover, at ejaculation the intensity of pleasure had
> declined. He didn’t think much about sex at all now, and
> he began to suspect his body was telling him something.
> Tim is exactly the sort of person to
> whom ten years ago I would have said, “Some changes you
> have to expect when your over fifty. We all get older, and
> it certainly doesn’t sound like there’s anything serious
> here for you to worry about.”
> Nothing serious about the whole
> quality of life, his sense of self-esteem, perhaps his
> marriage, and, in the long run, probably his health. Since
> traditional medical dogma was that there was no male
> menopause, I certainly hadn’t known any better. By the
> time Tim came to see me, I was smart enough to suggest we
> measure his testosterone levels. Tim’s testosterone was
> 190 nanograms per deciliter(ng/dl), a good deal less than
> half what one would expect in a man his age and perhaps a
> quarter of the average in young men. (Normal range is
> defined between 350 and 1000 ng/dl.). Once I looked at this
> number I was not surprised that Tim was tired, irritable,
> sexually quiescent, and off his game, in every sense.
> Every symptom I’ve described so
> far rapidly reversed itself with replacement doses of
> testosterone. Tim’s wife found a reinvigorated romantic
> partner, his golfing buddies at the country club discovered-
> perhaps to their dismay-that old Tim was suddenly driving
> the ball twenty yards further then he used to, and Tim
> himself realized that his life was not winding down, that he
> was not stuck in the mud, that he was himself again- morning
> erections and career motivation both restored. He now had
> energy that he hadn’t seen since his thirties.
> This may be the
> simplest story that I’ll tell in this book. Tim can stand
> for many men. I could easily go into my records and find
> fifty Tims. Not sick, not well-men who were simply wondering
> what in the dickens had happened to the man they used to
> know.
> Are
> You In The Gray Zone Yet
> We all age. Most of us observe this
> process unenthusiastically and would slow it if we could. In
> this book I want to make it possible for you to determine
> how far along you are in aging. Once you have that
> information, you’ll be better prepared to decide what you
> want to do about it. You might even decide to reverse the
> process.
> Most likely you think this sounds
> bizarre. Reverse aging? Surely it’s just as easy to tell
> the sun to stand still.
> Not really. It’s certainly true
> that in the past nothing could be done about aging. You knew
> that whatever way you felt at the present time, you were
> certainly going to feel a little older in a year or two. The
> process was irreversible, steady, and downhill.
> This simply isn’t true any longer.
> A carefully planned program of diet, exercise, and hormonal
> boosting or replacement can make you feel younger a year or
> two from now than you do today. I’ve seen it happen faster
> than that. And the lucky people who experienced these
> changes weren’t younger in their own minds. Their outward
> appearance, their metabolic functioning as measured by lab
> tests, their everyday standard of behavior-energy, attitude,
> drive-were all testimony to the fact that, for a while at
> least, they would enjoy the very special pleasure of
> spitting in the face of the calendar.

> Before we consider whether you, too,
> can objectively speaking make yourself feel younger, it
> makes good sense to establish a personal baseline. There are
> clusters of significant symptoms in such areas as brain
> function, sex function, general metabolic condition, and
> musculoskeletal wellness that go a long way toward
> determining how far you’ve traveled from the blithe days
> of your youth.
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