Is lowering estrogen too much a concern on Masteron when added to low dose testosterone?

[bbxtreme]

would 200mg mast show any cosmetic benefits?

Depends on how lean you are.

 

[Doitagain]

That number doesn't mean anything. 50s' for one person might be problematic with regard to sides, while for others it might be perfect. He didn't specify.

You asked for a number, not me. So why even asking if it doesn't matter.

 

[Doitagain]

Primo works differently than masteron in that regard. It seems to have a quite potent aromatase inhibiting property.
Masteron works more like a SERM, displacing estrogens from their own receptors in some tissues.

Drostanolone was found to exert no competition with estrogen receptors. Therefore it is unlikely that the growth inhibitory effect of drostanolone in human breast cancer is mediated through interaction with estradiol binding proteins as suggested earlier by some authors in the past. The SERM-like mode of action is an outdated idea.
It actually represses the expression of the ER on the cell membrane. It basically doesn't behave like an AI nor a SERM.
Maybe something like Fulvestrant would be a more fair comparison, but still a stretch.

 

[Love_to_Bodybuild]

Interesting. I have never seen too much estrogen suppression on my labs from Masteron which makes sense if it is acting like a SERM. Even though my numbers are higher I never felt any estrogen related sides while on Mast so this sounds correct.

Primo on the other hand I need to be careful with or estradiol will get crushed.

Have you had labs on primo?

 

[Love_to_Bodybuild]

Drostanolone was found to exert no competition with estrogen receptors. Therefore it is unlikely that the growth inhibitory effect of drostanolone in human breast cancer is mediated through interaction with estradiol binding proteins as suggested earlier by some authors in the past. The SERM-like mode of action is an outdated idea.
It actually represses the expression of the ER on the cell membrane. It basically doesn't behave like an AI nor a SERM.
Maybe something like Fulvestrant would be a more fair comparison, but still a stretch.

I think primo behaves the same way , since they're both dht derivative s and close anabolics: androgenic ratios. Do you think primo and masteron repress the expression of the ER on the cell membrane?

 

[pickapeck]

What dose of mast would you recommend as a safer alternative since I'll be using it with 140mg of test per week?

I think it's a little different for everybody. Mast doesn't hit mine at all but Primo does. I think you will have to test. Maybe use mast prop so you can adjust quickly once you have your results.

 

[bigzzz]

For me mast/primo/EQ all lower e2, so I would up the test for sure.

 

[SouthernMuscle]

Then why the fuck open your mouth about me? You seem to be fixated on me. You spend countless hours on this board with your retarded meme's and gifs. Again, you came at me.

yes. I don’t like you

a smart licensed therapist such as yourself should be able to grasp the concept of someone not liking someone else

 

[1fst400]

Uh no. That is not what happened.

no mention was made of other men. In fact no men at all were mentioned.

bullshit. You scared your rep will get tarnished? The simps that worship you here might find out you said to me? Not only was it way below the belt, but then you start getting creepy. Just quit. I didn't ask to interact with you and yet here you go with your big fucking passive aggressive mouth. Stop being a woman. Man up. Shut up and move on. I'm done with you.

 

[1fst400]

yes. I don’t like you

a smart licensed therapist such as yourself should be able to grasp the concept of someone not liking someone else

Yes, and I can spot a narcissistic piece of shit a mile away.

 

[SouthernMuscle]

bullshit. You scared your rep will get tarnished? The simps that worship you here might find out you said to me? Not only was it way below the belt, but then you start getting creepy. Just quit. I didn't ask to interact with you and yet here you go with your big fucking passive aggressive mouth. Stop being a woman. Man up. Shut up and move on. I'm done with you.

Nobody cares what you say dude. Youre a piece of shit

 

[SouthernMuscle]

Yes, and I can spot a narcissistic piece of shit a mile away.

Then why are you so confused

 

[1fst400]

Nobody cares what you say dude. Youre a piece of shit

Good come back. I'm out.

 

[SouthernMuscle]

bullshit. You scared your rep will get tarnished? The simps that worship you here might find out you said to me? Not only was it way below the belt, but then you start getting creepy. Just quit. I didn't ask to interact with you and yet here you go with your big fucking passive aggressive mouth. Stop being a woman. Man up. Shut up and move on. I'm done with you.

There’s nothing passive aggressive about it. I wish you the absolute worst

 

[SouthernMuscle]

Good come back. I'm out.

We’ll see, i doubt you can contain your mid 40’s low test facebook anger

 

[phoenix2]

Drostanolone was found to exert no competition with estrogen receptors. Therefore it is unlikely that the growth inhibitory effect of drostanolone in human breast cancer is mediated through interaction with estradiol binding proteins as suggested earlier by some authors in the past. The SERM-like mode of action is an outdated idea.
It actually represses the expression of the ER on the cell membrane. It basically doesn't behave like an AI nor a SERM.
Maybe something like Fulvestrant would be a more fair comparison, but still a stretch.

Maybe probably, who knows certainly. But it's a fact that people react differently to these compounds. So you have to try and experiment by yourself.
But relying on drostanolone solo as estrogen control, especially with high test and/or for people who know that are prone to aromatization/estrogen sides, could be a mistake. Better to always have an AI on hand.

 

[Reno911]

Have you had labs on primo?

A bunch. I have to have Test close to double or add something in that will aromatize like Deca or NPP.

Personally I prefer Estradiol at least 30 or higher. At under 20, I def feel like shit and it also hits HDL harder.

 

[jaxino]

Drostanolone was found to exert no competition with estrogen receptors. Therefore it is unlikely that the growth inhibitory effect of drostanolone in human breast cancer is mediated through interaction with estradiol binding proteins as suggested earlier by some authors in the past. The SERM-like mode of action is an outdated idea.
It actually represses the expression of the ER on the cell membrane. It basically doesn't behave like an AI nor a SERM.
Maybe something like Fulvestrant would be a more fair comparison, but still a stretch.

I am not here to take any position, just to share this video and hear your opinion.

If what you wrote is true, those 2 guys have really misunderstood how Masteron really works.

 

[Doitagain]

Maybe probably, who knows certainly.

Maybe probably, what, exactly? I posted about the actual mode of action of Drostanolone , and that's cerainly not my "opinion".

 

[Doitagain]

I am not here to take any position, just to share this video and hear your opinion.

If what you wrote is true, those 2 guys have really misunderstood how Masteron really works.

Again I have no "opinion", as no individual with half a brain should when there's actual research and findings available.